Search PubMed⌕ Search

Biomedical subjects

R Hehlmann

Publications and source records attributed to R Hehlmann.

At least 271 records · Page 15Linked to original sources
PubMed1972

Human sarcomas contain RNA related to the RNA of a mouse leukemia virus.

Labeled DNA complementary to the RNA of the Rauscher leukemia virus was hybridized with RNA from the polysome fraction of human sarcomas. Eighteen out of 25 specimens contained RNA possessing homology to the RNA of the mouse leukemia virus but not to that of the unrelated viruses causing mammary tumors in mice or myeloblastosis in chickens. Further, no normal adult or fetal tissues showed significant amounts of RNA specific to mouse leukemia virus. It appears that human sarcomas contain RNA sequences homologous to those found in an agent related to a virus known to cause sarcomas in mice.

Animals↗
PubMed1972

RNA in human leukemic cells related to the RNA of a mouse leukemia virus (leukocytes-RNA-DNA hybridization-rauscher virus-polysomal RNA).

Molecular hybridization with radioactively labeled DNA complementary to the RNA of the Rauscher leukemia virus was used to probe for homologous RNA in the polysome fraction of human leukemic cells. The leukocytes of 24 out of 27 patients examined contained RNA possessing homology to that of the mouse leukemia agent, but not to that of the unrelated viruses causing mammary tumors in mice or myeloblastosis in chickens. Further, no control human leukocytes or other adult and fetal tissues showed significant levels of the leukemia-specific RNA. It would appear that human leukemic cells contain RNA sequences homologous to those found in a viral agent known to cause leukemia in an experimental animal. The fact that human sarcomas have also been shown to contain this type of RNA points to a remarkable parallelism in the leukemias and sarcomas of mice and men.

Animals↗
PubMed1972

Viral-related RNA in Hodgkins' disease and other human lymphomas.

Molecular hybridization with radioactively labeled DNA complementary to the RNA of the Rauscher leukemia virus was used to probe for homologous RNA in human lymphomas. 22 of 32 specimens contained RNA possessing homology to the RNA of the mouse leukemia virus, but not to that of the unrelated viruses causing mammary tumors in mice or myeloblastosis in chickens. Normal adult and fetal tissues failed to show significant levels of the leukemia-specific RNA. It appears that human lymphomas contain RNA sequences homologous to those found in a viral agent known to cause leukemia and lymphomas in an experimental animal. The fact that human leukemias and sarcomas also contain this type of RNA further emphasizes a remarkable similarity between the corresponding neoplasias of murine and human origin.

Animals↗