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Biomedical subjects

R Hawthorn

Publications and source records attributed to R Hawthorn.

4 recordsLinked to original sources
PubMed2000

A randomised comparison and economic evaluation of laparoscopic-assisted hysterectomy and abdominal hysterectomy.

OBJECTIVES: To determine the safety, cost effectiveness and effect on quality of life of laparoscopic-assisted vaginal hysterectomy (LAVH) compared with total abdominal hysterectomy (TAH) in the management of benign gynaecological disease. DESIGN: Randomised controlled trial and economic evaluation. SETTING: Three hospitals in the West of Scotland. PARTICIPANTS: Two hundred women scheduled for an abdominal hysterectomy for benign gynaecological disease. MAIN OUTCOME MEASURES: Conversion rate of LAVH to TAH, complication rates, NHS resource use and costs, quality of life using EuroQol 5 D visual analogue scale, and achievement of milestones. RESULTS: The overall incidence of operative complications was 14% in the TAH group and 8% in the LAVH group, with an 8% conversion rate. Length of operation was significantly greater in the women having LAVH at 81 +/- 30 min vs 47 +/- 16 min (P < 0.001). There was no difference in analgesic requirements between the groups although there was a significantly shorter hospital stay for those having LAVH. The rate of post-surgery recovery, satisfaction with operation and quality of life at four weeks post-operative were similar in the two groups of women. LAVH was significantly more expensive than TAH and remained more expensive for all but the most extreme scenario. CONCLUSIONS: This study demonstrates that despite the decreased length of hospital stay, LAVH is more expensive than TAH. In addition, recovery following operation and patient satisfaction were not affected by the route chosen. It is unlikely that LAVH represents an efficient use of NHS resources.

Adult↗
PubMed1991

Low dose danazol in the treatment of the premenstrual syndrome.

This double-blind, randomized, crossover study compared the efficacy and safety of danazol (100 mg twice daily) with matching placebo in the treatment of severe premenstrual syndrome. Nineteen patients were randomly allocated to receive danazol for 3 months followed by placebo, and 18 to receive treatment in the reverse order. Assessments of overall condition showed improvement to be statistically significantly more likely with danazol than with placebo (P less than 0.001) after 3 months' treatment. Furthermore, daily visual analogue scale assessments demonstrated statistically significantly better premenstrual scores with danazol in comparison to placebo for breast discomfort, irritability, depression, anxiety, mood swings, crying, depressed libido and abdominal swelling. It is concluded that danazol provides effective and generally well tolerated treatment for severe premenstrual syndrome.

Adult↗
PubMed1975

Anatomy and histology of the human temporomandibular joint.

1. The anatomy and histology of the human temporomandibular joint indicates that the meniscus is firmly attached to the mandibular condyle and that during translatory movements the meniscus and condyle move concomitantly. The lateral pterygoid muscle, both inferior and superior heads insert into the meniscus and the pterygoid fovea of the condyle. 2. The structure of the gracilis and pars posterior indicate that these are the parts of the meniscus that are exposed to friction during jaw movement. It is suggested that during hinge movement the sagittal crest of the condyle moves from underneath the pars posterior to underneath the pars gracilis. 3. The restraining ligament for the articulation appears to be the lateral ligament. Its function is to keep the articular surfaces relatively close together during movement and to restrain lateral and posterior movements of the condyle. Its intimate association with the deep fibres of the masseter muscle appears to be important. 4. The fact that the meniscus is thicker medially than laterally would indicate that its major function is to smooth out the incongruities between the joint surfaces. 5. The sphenomandibular ligament as well as being a 'guy' ligament is intimately associated with the postero-superior medial capsular meniscal complex. The medial capsular complex would seem to contribute to the major part of the anterior ligament to the malleus. 6. Remodelling of the articular surfaces occur throughout life by progressive and regressive remodelling. However, if the remodelling processes increase, either the medio-lateral or antero-posterior dimensions of the joint an osteoarthritic condition prevails. 7. Excessive progressive remodelling appears to be due to abnormal positions of the condyle in the maximal intercuspal position. It can be caused by orthodontic procedures or by experimental displacement of the condyle. 8. The transitional zone appears to be important in the aetiology of osteoarthritis since when this zone comes under pressure proliferation of cartilage cells occur which may be transformed into bone, resulting in the hooked condyle.

Cartilage, Articular↗