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Biomedical subjects

R Hausman

Publications and source records attributed to R Hausman.

At least 19 recordsLinked to original sources

Is pseudoepitheliomatous, micaceous and keratotic balanitis synonymous with verrucous carcinoma?

Two cases of pseudoepitheliomatous, micaceous and keratotic balanitis are presented and their clinical and histological features are discussed. This rare condition of the glans penis was originally thought to be benign, but more recent evidence indicates that the lesion is a manifestation of verrucous carcinoma. Consequently, the treatment of choice is excision with a wide margin. We suggest the new name, micaceous and verrucous malignant balanitis.

Aged

Multiple angiomatous proliferations of ileal stoma following Campylobacter enteritis. Effect of laser photocoagulation.

Multiple polypoid sessile tumors arose at the tip of the ileal stoma of a 37-year-old man, who previously underwent proctocolectomy for ulcerative colitis. The lesions developed shortly after a well-established gastrointestinal infection with Campylobacter jejuni with mucosal ulceration. The histological and ultrastructural examination showed angiomatous proliferations, reminiscent of pyogenic granuloma. The destruction of the tumors by laser photocoagulation was followed by superficial ulcerations of the mucosa, which healed without scarring. Small recurrences, however, could not be prevented.

Adult

The enigma of juvenile plantar dermatosis.

Juvenile plantar dermatosis, which is sometimes accompanied by palmar changes, is a chronic condition. It is characterized by shiny redness, anhidrosis, and fissuring of the skin. Microscopically, focal inflammatory changes at the junctions of sweat-gland ducts and acrosyringia are seen. The pathogenesis is unknown. We surmise that individual susceptibility, bacterial colonization, and the use of man-made leather substitutes and fibers are the main causative factors.

Adolescent

The cutaneous pathology of facial lesions in Cowden's disease.

A study of 11 facial lesions from 7 patients with Cowden's disease indicated that most belong to a spectrum of related follicular malformations. The most distinctive lesions included multiple facial trichilemmomas, which were frequently cylindrical, resembling a blown-up hair follicle, but could be lobular. Four of the 5 trichilemmomal lesions were from the centrofacial area. Three periauricular lesions showed the pattern of tumor of follicular infundibulum without trichilemmonal features. Two lesions were epidermal without a follicular component and resembled digitate warts. No evidence of virus infection was found using an antiserum to papilloma virus.

Adult

The cutaneous pathology of extrafacial lesions in Cowden's disease.

Twenty extrafacial lesions from 6 patients with Cowden's disease were studied. Most were hyperkeratotic papillomas that resembled verruca vulgaris, acrokeratosis verruciformis, or hyperkeratotic acanthomas. Small hyperkeratotic papillomas frequently showed abnormalities of the follicular infundibulum. Occasionally, follicular abnormalities were seen without concomitant epidermal hyperplasia. It is concluded that some of the extrafacial lesions may originate from the follicular infundibulum. No evidence of a virus infection was found using an antiserum to papilloma virus.

Adult

Keratosis palmoplantaris nummularis ("hereditary painful callosities"). Clinical and histopathologic aspects.

Three families are described. A number of the members of these families showed nummular keratoses on the plantar pressure points. The lesions usually appeared when the children began to walk. They progressed slowly and were often accompanied by pain. The hands showed only minor lesions, which frequently followed manual labor. Extrapalmoplantar lesions were rare. The histopathologic findings in our patients were those of focal epidermolytic hyperkeratosis. The classification of this type of dominant hereditary focal palmoplantar keratosis, for which the name keratosis palmoplantaris nummularis is suggested, is discussed.

Aged

Fatal forceps.

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Birth Injuries

Late prurigo of pregnancy.

Seven patients who developed a characteristic pruritic rash in late pregnancy are described. Clinically, the lesions consisted of erythematous urticarial papules and plaques, with vesicles in some cases. The eruption started in the striae on the abdomen and spread over the thighs and in most cases also over the arms and buttocks. Biopsy showed lymphocytic vasculitis with a varying admixture of eosinophils and only minor epidermal changes. Immunofluorescence examination of six cases showed C3 deposition among the dermoepidermal junction in only one case. The lymphocytes, identified by a specific anti-T-cell serum, appeared to be mostly T-cells. The nomenclature of pruritic skin disease in late pregnancy is confusing, but the term 'late prurigo of pregnancy' seems appropriate for this condition.

Female

Vascular ectasias (angiodysplasias) of the cecum and the ascending colon.

Over a period of two years (1977-1979) the diagnosis symptomatic vascular ectasias of the colon was made in 7 patients. The authors describe 3 cases with corresponding illustrations. The diagnostic value of selective mesenteric artery angiography and fiber endoscopy for the diagnosis and treatment is stressed. The possible pathogenesis of the vascular abnormality is discussed with reference to the histology and the literature.

Aged

[Folliculitis caused by pityrosporum].

A 21 year old woman with folliculitis caused by Pityrosporum is described. Differential-diagnosis especially with regard to acne vulgaris is discussed.

Adult

Neuroblastoma with a fulminant clinical course caused by tumor embolism.

The case of a 2 1/2-year-old girl with a well-nigh asymptomatic neuroblastoma of the left adrenal is described. In the final stage it gave rise to unusual clinical signs. The tumor had grown into the inferior vena cava via the left suprarenal and renal veins. Dissolution of the soft tumor mass in the vena cava caused fatal massive embolism of lungs and brain.

Adrenal Gland Neoplasms

Occlusive phlebitis, a diagnostic feature in Riedel's thyroiditis.

Five cases of Riedel's invasive fibrous thyroiditis are presented. Clinically and histopathologically all cases fulfilled the criteria for this lesion. In both small and large veins there were inflammatory changes and obliteration of the lumen, followed by sclerosis. These changes were found in each operative specimen, and seemed to be a diagnostic feature of invasive fibrous thyroiditis. We consider this change to be an occlusive phlebitis, and have noted that it occurs in association with multifocal fibrosclerosis. Three stages can be recognised: infiltrative, occlusive and sclerotic. In other thyroid lesions such as Hashimoto's thyroiditis, granulomatous thyroiditis of the Quervain type and adenomatous goitre these peculiar changes in the veins were not found.

Adult

Lymphangiectasia of the small intestine as an acute surgical problem.

Two cases of lymphangiectasia of the small intestine in elderly women are presented. The condition manifested itself in one case by a sudden perforation of the jejunum; in the other case by ileus of the terminal ileum. In both cases the disease process pursued a relentless course that ultimately led to the death of the patients. Elective surgery in patients with lymphangiectasia has been performed before. Acute surgery of lymphangiectasia of the small intestine with complaints of acute abdomen, obstruction or perforation as presenting signs of the disease has not been described previously.

Aged