Search PubMed⌕ Search

Biomedical subjects

R Hart

Publications and source records attributed to R Hart.

153 records · Page 9Linked to original sources
PubMedDate not supplied

Multiple cerebral infarctions and dementia associated with anticardiolipin antibodies.

Antibodies to negatively charged phospholipids including cardiolipin have been recognized in the sera of patients with systemic lupus erythematosus and other disorders. We report 4 patients who experienced cerebral infarctions and dementia in association with anticardiolipin antibodies. These patients did not have the characteristic lupus anticoagulant or systemic lupus erythematosus. The occurrence of anticardiolipin antibodies in patients with multiple cerebral infarctions who do not have evidence of a systemic vasculitis or inflammatory condition suggests that this association may be more common than previously recognized. It may be useful to test for the presence of anticardiolipin antibodies in patients who have unexplained cerebral infarctions.

Adult↗
PubMedDate not supplied

Rationale for the use of dietary control in toxicity studies--B6C3F1 mouse.

Significant variability in critical study parameters such as tumor incidences and survival, increasing tumor incidence and decreasing survival in common toxicity test models, and agent-induced changes in body weight (BW) and BW distribution all generate concern about the reproducibility, consistency, and equity of chronic toxicity tests used in regulation. These concerns have led to suggestions to control BW in chronic tests by the modulation of dietary intake without inducing malnutrition [dietary control (DC)] thereby minimizing tumor and survival variability both between and within studies. Evaluating the reports of the best controlled set of chronic experiments, the National Toxicology Program bioassay series, from studies initiated from 1981 to 1990, there is an increase in tumor incidence, especially liver tumors, with a consistent increase in BW. The studies are classified as to whether normal or aberrant BW growth curves occur. When the studies with normal growth curves are considered, the variance in the BW at 12 mo on test (BW12) can account for over 50% of the variance in liver tumor incidence. Additional stratification by study type, which alter tumor prevalences, as well as appreciation of housing effects [group housing decreases survival (in male mice) and induces tumors in males and females when compared to individual housing], further increase the strength of the correlations, accounting for up to 90% of the variance seen in tumor incidences. These updated analyses further support the hypothesis that it is the BW variation that is resulting in much of the variability seen in tumor incidences and refine the suggestions for the BW curves used as the desired targets for DC.

Animals↗
PubMedDate not supplied

Building a compliance program. Guidelines for physician practices.

Federal investigations of physician billing practices will only grow more intense in 1998. Regular self audit, especially of CPT coding, can help practices stay out of the limelight. An established compliance program and high-ranking compliance officer are also becoming standard. Compliance programs should pay particular attention to "incident to" billing, level 5 E/M codes, time-based E/M codes, codes with both technical and professional component services, consultations, critical care codes and physician care plan oversight. Even group practices that use billing companies need to stay alert. Physicians are liable for the acts of the billing company whether they knew or should have known submitted claims were false.

Financial Audit↗
PubMedDate not supplied

Age-heterogamy and Canadian union.

This study provides a much-needed exploration of the determinants of age-discrepant unions in Canada. What little research has been conducted in this area of sociology of the family is now outdated. Further, the growing number of Canadians living in nonmarital cohabitation warrants their inclusion in any consideration of contemporary, heterosexual unions, and we have done so here. Utilizing multinomial logit modeling techniques, we analyze data drawn from the 1995 Canadian General Social Survey. We find that cohabitations and remarriages are more likely to be age-discrepant than marriages, and that as age at union formation increases, so does the likelihood that the union will be age-heterogamous. Although we hypothesized a positive relationship between education and the chances of age-heterogamous unions because the availability of eligible mates may decrease with education, we actually find an inverse association for women: a one-level increase in education decreases a woman's odds of entering an age-discrepant union by about 4 percent. We speculate that for women, greater education (economic position) may increase age-homogamy because they may be more economically attractive and thus more able to select a partner of their own age.

Adult↗
PubMedDate not supplied

A review of instrumentation and therapeutic techniques in the diagnosis and management of supraventricular tachycardia.

Paroxysmal supraventricular tachycardia can usually be managed without any specific therapy or with an appropriate drug program. Some patients, however, are resistant to conventional therapy. In the past decade, the electrophysiologic pathogenic mechanisms of this rhythm disorder have been elucidated, and this, coupled with progress in intracardiac instrumentation, has enabled the physician to induce specific rhythm disorders and to map them to determine an ideal, specially tailored method of treatment. As a result, the use of radiofrequency pacing and surgery are becoming increasingly important in the treatment of patients with paroxysmal supraventricular tachycardia, especially those with arrhythmias related to Wolff-Parkinson-White syndrome.

Adult↗
PubMedDate not supplied

Race and survival from breast cancer: based on Cancer and Leukemia Group B trial 8541.

PURPOSE: The purpose of this research was to evaluate the prognostic significance of race and survival in stage II breast cancer among women treated with adjuvant chemotherapy in the Cancer and Leukemia Group B (CALGB) trial 8541. MATERIALS AND METHODS: A total of 1572 patients with node-positive breast cancer were entered in CALGB trial 8541. This study opened in January 1985 and randomized patients to receive "high-dose," "standard-dose," or "low-dose" adjuvant CAF (cyclophosphamide, doxorubicin, and fluorouracil) chemotherapy. Patients were stratified according to treatment of the primary lesion (mastectomy or breast conservation), menopausal status, number of positive lymph nodes, and estrogen-receptor status. Twelve percent of the patients entered in this study were African-American, 84% were white, and 4% were of other racial backgrounds. RESULTS: African-Americans and whites were evenly distributed on all three arms. In a univariate analysis, African-Americans were more likely to have a reduced survival and shorter time to relapse than other patients. Race was moderately associated with tumor size, receptor status, and type of surgery. In a multivariate analysis, after adjusting for the dose of chemotherapy, number of lymph nodes, estrogen-receptor status, and age, race was no longer of prognostic significance. DISCUSSION: After adjustment for other well-recognized prognostic factors, race appears to have no independent prognostic significance for survival from stage II breast cancer among women receiving adjuvant CAF chemotherapy.

Black People↗