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R Hari

Publications and source records attributed to R Hari.

At least 91 records · Page 5Linked to original sources
PubMed1997

Evidence for reactive magnetic 10-Hz rhythm in the human auditory cortex.

We tested the hypothesis that neurons in the human auditory cortex show spontaneous oscillations around 10 Hz, and that this activity ('tau' rhythm) is affected by auditory input. Cortical activity was recorded with a 122-channel whole-scalp neuromagnetometer from healthy adults while they were presented with monaural 500-ms bursts of white noise. The reactivity of spontaneous oscillations was studied over the whole cortex using the Temporal Spectral Evolution method. Oscillatory 6.5-9.5 Hz activity, with sources in the superior temporal lobes, was transiently suppressed by the sounds in eight out of nine subjects. Our results support the existence of a distinct, reactive auditory rhythm in the human temporal cortex.

Adult↗
PubMed1997

Human auditory cortex is activated by omissions of auditory stimuli.

Cortical signals associated with infrequent tone omissions were recorded from 9 healthy adults with a whole-head 122 channel neuromagnetometer. The stimulus sequence consisted of monaural (left or right) 50-ms 1-kHz tones repeated every 0.2 or 0.5 s, with 7% of the tones randomly omitted. Tones elicited typical responses in the supratemporal auditory cortices. Omissions evoked strong responses over temporal and frontal areas, independently of the side of stimulation, with peak amplitudes at 145-195 ms. Response amplitudes were 60% weaker when the subject was not attending to the stimuli. Omission responses originated in supratemporal auditory cortices bilaterally, indicating that auditory cortex plays an important role in the brain's modelling of temporal characteristics of the auditory environment. Additional activity was observed in the posterolateral frontal cortex and in the superior temporal sulcus, more often in the right than in the left hemisphere.

Acoustic Stimulation↗
PubMed1997

Modulation of human cortical rolandic rhythms during natural sensorimotor tasks.

We studied modulation of cortical neuromagnetic rhythms in association with left and right median nerve stimulation, during rest, finger movements, and passive tactile hand stimulation, in seven healthy, right-handed adults. In the rest condition, the amplitude of the rhythmic sensorimotor activity decreased immediately after the median nerve stimuli and increased above the prestimulus level within 0.4 s afterward, especially in the 7- to 25-Hz band. The rebound occurred 100-300 ms earlier for 20 (7-15)-than for 10 (15-25)-Hz activity. Suppressions and rebounds were strongest in the contralateral sensorimotor hand area for the 20-Hz, but not for the 10-Hz, activity. The maximum rebound was on average 22-34% stronger in the left than in the right hemisphere. Active exploration of objects abolished rebounds of both 10- and 20-Hz signals in the contralateral hemisphere and markedly diminished them ipsilaterally. Finger movements without touching an object and passive tactile stimulation produced a weaker effect. The sensorimotor rhythms thus show a characteristic suppression and subsequent rebound after electrical median nerve stimulation. The rebound is left-hemisphere dominant in right-handed subjects and its suppression reveals bilateral cortical activation during both motor tasks and passive tactile stimulation, especially for explorative finger movements.

Adult↗
PubMed1997

Activation of human V5 complex and rolandic regions in association with moving visual stimuli.

We recorded magnetoencephalographic responses from seven healthy humans during the presentation of stationary and rotating radial gratings. Rotations lasting 1 s evoked movement-specific sustained activity in the parieto-occipitotemporal border area, in agreement with the activation of the V5 complex specialized for the analysis of movement. The source areas of the movement-specific sustained fields were transiently active 100-130 ms after the onsets of both rotating and stationary stimuli, suggesting that movement-related cortical areas respond to any transient changes in the visual environment. Transients were evoked also in other brain areas 60-200 ms after onsets of both stimuli. Four subjects displayed additional motion-related sustained activity in the rolandic region. Sustained activity continued after the stimulus movement in several subjects during perception of the movement aftereffect. The transient activity may evoke visual attention while sustained activity of the V5 complex may be related to the conscious perception of movement.

Adult↗
PubMed1997

Involvement of primary motor cortex in motor imagery: a neuromagnetic study.

Functional brain imaging studies have indicated that several cortical and subcortical areas active during actual motor performance are also active during imagination or mental rehearsal of movements. Recent evidence shows that the primary motor cortex may also be involved in motor imagery. Using whole-scalp magnetoencephalography, we monitored spontaneous and evoked activity of the somatomotor cortex after right median nerve stimuli in seven healthy right-handed subjects while they kinesthetically imagined or actually executed continuous finger movements. Manipulatory finger movements abolished the poststimulus 20-Hz activity of the motor cortex and markedly affected the somatosensory evoked response. Imagination of manipulatory finger movements attenuated the 20-Hz activity by 27% with respect to the rest level but had no effect on the somatosensory response. Slight constant stretching of the fingers suppressed the 20-Hz activity less than motor imagery. The smallest possible, kinesthetically just perceivable finger movements resulted in slightly stronger attenuation of 20-Hz activity than motor imagery did. The effects were observed in both hemispheres but predominantly contralateral to the performing hand. The attempt to execute manipulatory finger movements under experimentally induced ischemia causing paralysis of the hand also strongly suppressed 20-Hz activity but did not affect the somatosensory evoked response. The results indicate that the primary motor cortex is involved in motor imagery. Both imaginative and executive motor tasks appear to utilize the cortical circuitry generating the somatomotor 20-Hz signal.

Adult↗
PubMed1997

Activation of a distributed somatosensory cortical network in the human brain. A dipole modelling study of magnetic fields evoked by median nerve stimulation. Part I: Location and activation timing of SEF sources.

Cortical areas responsive to somatosensory inputs were assessed by recording somatosensory evoked magnetic fields (SEF) to electrical stimulation of the left median nerve at wrist, using a 122-SQUID neuromagnetometer in various conditions of stimulus rate, attentional demand and detection task. Source modelling combined with magnetic resonance imaging (MRI) allowed localisation of six SEF sources on the outer aspect of the hemispheres located respectively: (1) in the posterior bank of the rolandic fissure (area SI), the upper bank of the sylvian fissure (parietal opercular area SII) and the banks of the intraparietal fissure contralateral to stimulation, (2) in the SII area ipsilateral to stimulation and (3) in the mid-frontal or inferior frontal gyri on both sides. All source areas were found to be simultaneously active at 70-140 ms after the stimulus, the SI source was the only one active already at 20-60 ms. The observed activation timing suggests that somatosensory input from SI is processed to higher-order areas through serial feedforward projections. However the long-lasting activations of all sources and their overlap in time is also compatible with a top-down control mediated via backward projections.

Adult↗
PubMed1997

Activation of a distributed somatosensory cortical network in the human brain: a dipole modelling study of magnetic fields evoked by median nerve stimulation. Part II: Effects of stimulus rate, attention and stimulus detection.

In this study we used a repeated measures design and univariate analysis of variance to study the respective effects of ISI, spatial attention and stimulus detection on the strengths of the sources previously identified by modelling SEFs during the 200 ms following mentally counted left median nerve stimuli delivered at long and random ISIs (Part I). We compared the SEF source strengths in response to frequent and rare stimuli, both in detection and ignoring conditions. This permitted us to establish a hierarchy in the effects of ISI, attention and stimulus detection on the activation of the cortical network of SEF sources distributed in SI and posterior parietal cortex contralateral to stimulation, and in the parietal operculum (SII) and premotor frontal cortex of both hemispheres. In all experimental conditions the SI and parietal opercular sources were the most active. All sources were more active in response to stimuli delivered at long and random ISIs and the frontal sources were activated only in this condition of stimulation. Driving the subject's attention toward the side stimulated had no detectable effect on the activity of SEF sources at short ISI. At long ISIs mental counting of the stimuli increased the responses of all sources except SI. These results suggest that activation of frontal sources during mental counting could reflect a working memory process, and that of posterior parietal sources a spatial attention effect detectable only at long ISIs.

Adult↗
PubMed1997

Human cortical oscillations: a neuromagnetic view through the skull.

The mammalian cerebral cortex generates a variety of rhythmic oscillations, detectable directly from the cortex or the scalp. Recent non-invasive recordings from intact humans, by means of neuromagnetometers with large sensor arrays, have shown that several regions of the healthy human cortex have their own intrinsic rhythms, typically 8-40 Hz in frequency, with modality- and frequency-specific reactivity. The conventional hypotheses about the functional significance of brain rhythms extend from epiphenomena to perceptual binding and object segmentation. Recent data indicate that some cortical rhythms can be related to periodic activity of peripheral sensor and effector organs.

Cerebral Cortex↗
PubMed1997

Magnetoencephalographic cortical rhythms.

We have characterized the magnetic 10- and 20-Hz rhythms recorded with a whole-scalp neuromagnetometer during different conditions. Sources of the posterior 10-Hz (alpha) rhythm clustered mainly around the parieto-occipital sulcus and, to a lesser extent, around the calcarine sulci, with several generators. Temporal Spectral Evolution (TSE) analysis, used to follow event-related changes in the different frequency bands, showed strong dampening of the alpha within 200 ms after the appearance of a visual stimulus and also during visual imagery. Suppression was often followed by a rebound above the baseline level. The rolandic mu rhythm consisted of 10- and 20-Hz components with different reactivity and source locations. The 10-Hz component seems to be mainly somatosensory in origin whereas the 20-Hz signal also receives contributions from the motor cortex, and even shows 'motorotopy' in its reactivity: the source locations depend in a somatotopical manner on the site of the moving body part. The frequency composition of the posterior spontaneous activity was disturbed in patients with small infarcts of the medial thalamus. It is shown with simulations that a surprisingly small number of synchronized cortical neurons could generate the major part of the recorded oscillatory signal. Finally, some clarifications are suggested to the terminology of brain rhythms.

Animals↗
PubMed1997

Right-hemisphere preponderance of responses to painful CO2 stimulation of the human nasal mucosa.

We recorded whole-scalp cerebral magnetic fields from healthy adults to painful CO2 pulses (duration 200 ms, concentration 65-90%), led to the left or right nostril once every 20 or 30 s. The stimuli were embedded in a continuous airflow (140 ml/s, 36.5 degrees C, relative humidity 80%) to prevent alterations in the mechanical and thermal conditions of the nasal mucosa. The recording passband was 0.03-90 Hz and 16 single responses were averaged per run. Five out of the 9 subjects showed replicable and artifact-free responses 280-400 ms after stimulus onset. The main responses originated close to the second somatosensory cortex (SII), most frequently in the right hemisphere, and also in the rolandic areas, mostly on the left. The signals were considerably stronger over the right than the left frontotemporal region, with a right-to-left ratio of 2.3 for areal mean signal amplitudes calculated across 16 channels, for both left and right nostril stimuli. Air puffs delivered to the nasal mucosa resulted in a trend for right-hemisphere dominant responses, but responses to air puff stimulation of the lip and the forehead were symmetric. The right-hemisphere dominance of the SII responses may be associated with the painful, and thus unpleasant, nature of the CO2 stimulus, thereby suggesting involvement of the right hemisphere in emotional/motivational aspects of trigeminal pain, in agreement with the role of the trigeminal pathways as a general warning system.

Acute Disease↗
PubMed1997

Face-specific responses from the human inferior occipito-temporal cortex.

Whole-head neuromagnetic responses were recorded from seven subjects to pictures of faces and to various control stimuli. Four subjects displayed signals specific to faces. The combination of functional information from magnetoencephalography and anatomical data from magnetic resonance images suggests that the face-specific activity was generated in the inferior occipitotemporal cortex. All four subjects showed the face-specific response in the right hemisphere, one of them also in the left. Our results, together with recent position emission tomography and lesion studies, suggest a right-hemisphere preponderance of face processing in the inferior occipitotemporal cortex.

Adult↗
PubMed1997

Cortical control of human motoneuron firing during isometric contraction.

We recorded whole scalp magnetoencephalographic (MEG) signals simultaneously with the surface electromyogram from upper and lower limb muscles of six healthy right-handed adults during voluntary isometric contraction. The 15- to 33-Hz MEG signals, originating from the anterior bank of the central sulcus, i.e., the primary motor cortex, were coherent with motor unit firing in all subjects and for all muscles. The coherent cortical rhythms originated in the hand motor area for upper limb muscles (1st dorsal interosseus, extensor indicis proprius, and biceps brachii) and close to the foot area for lower limb muscles (flexor hallucis brevis). The sites of origin corresponding to different upper limb muscles did not differ significantly. The cortical signals preceded motor unit firing by 12-53 ms. The lags were shortest for the biceps brachii and increased systematically with increasing corticomuscular distance. We suggest that the motor cortex drives the spinal motoneuronal pool during sustained contractions, with the observed cortical rhythmic activity influencing the timing of efferent commands. The cortical rhythms could be related to motor binding, but the rhythmic output may also serve to optimize motor cortex output during isometric contractions.

Adult↗
PubMed1996

Visual awareness of objects correlates with activity of right occipital cortex.

In the search for human neural correlates of visual awareness, cortical magnetic responses to coherent and meaningful objects were compared with responses to disorganized and meaningless non-objects when observers tried to detect the coherent objects. Three brief stimulus durations were included to vary the detection rate of the objects. Of the multiple brain regions activated, only the right lateral occipital cortex showed signals correlating with the proportion of correct object detections. The results suggest an important role for this area in visual awareness of objects.

Adult↗
PubMed1996

Magnetic source imaging during a visually guided task.

The cerebellum is heavily involved in the control of accurate eye movements. Cerebellar lesions typically results in nystagmus and dysmetria, inability to stop the eyes at the end of a conjugate movement. Up to now, no cerebellar activity has been identified from non-invasive electrophysiological data. Here we report on neuromagnetic signals of eight healthy subjects in association with visually guided horizontal saccades. The signals were averaged with respect to electrically recorded saccade onsets and their topography revealed activation of the cerebellar vermis starting about 30 ms before and peaking about 170 ms after the saccade onset. In darkness, the cerebellar signals, possibly arising from the cerebellum, were suppressed less than the coinciding signals from the posterior parietal lobe.

Adult↗
PubMed1996

Cortical sources of human short-latency somatosensory evoked fields to median and ulnar nerve stimuli.

;;;;;õry evoked magnetic fields were measured with a 122-channel whole-scalp neuromagnetometer from seven healthy adults. Electric stimuli, with an intensity above the motor threshold, were delivered once every 0.5 s alternately to the median and ulnar nerves at the wrist; both wrists were stimulated successively within one session. In most subjects, two distinct neural sources were identified at the contralateral primary somatosensory cortex SI for both stimuli. The first source (M20) peaked at 21-22 ms and indicated activation of area 3b in the contralateral SI hand region. The same source peaked with opposite current direction at 32 ms. The second source (M40) was slightly medial to M20 and exhibited two peaks with the same current direction, first at 25 ms and most prominently at 42 ms. M20 was on average 7 mm more lateral along the central sulcus for median than ulnar nerve stimuli, in agreement with the somatotopic organization of the SI cortex; similar organization for M40 was less clear. These results suggest that M20 and M40 to upper limb stimulation represent activation of distinct neuronal populations in hand SI cortex, presumably in area 3b.

Adult↗
PubMed1996

Activation of human mesial cortex during somatosensory target detection task.

We recorded somatosensory evoked fields (SEFs) from 10 healthy subjects to ulnar and median nerve stimuli presented at random intervals of 2.4-21.6 s. The subjects either counted the stimuli or ignored them by reading a book. The stimuli activated in both conditions the contralateral SI cortex, the ipsi- and contralateral SII cortices, and the posterior parietal cortex (PPC), in line with earlier observations. In addition, a novel response was observed in nine subjects at 120-160 ms. It was clearly enhanced by attention and was generated in the mesial cortex of the paracentral lobule, close to the end of the central sulcus.

Acoustic Stimulation↗
PubMed1996

Information processing in the human brain: magnetoencephalographic approach.

Rapid progress in effective methods to image brain functions has revolutionized neuroscience. It is now possible to study noninvasively in humans neural processes that were previously only accessible in experimental animals and in brain-injured patients. In this endeavor, positron emission tomography has been the leader, but the superconducting quantum interference device-based magnetoencephalography (MEG) is gaining a firm role, too. With the advent of instruments covering the whole scalp, MEG, typically with 5-mm spatial and 1-ms temporal resolution, allows neuroscientists to track cortical functions accurately in time and space. We present five representative examples of recent MEG studies in our laboratory that demonstrate the usefulness of whole-head magnetoencephalography in investigations of spatiotemporal dynamics of cortical signal processing.

Auditory Perception↗