Case of the month: death and devices. Autopsy Committee of the College of American Pathologists.
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Biomedical subjects
Publications and source records attributed to R Hanzlick.
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CONTEXT: Medical legal investigations in the United States (primarily unnatural or suspected unnatural deaths) are carried out by medical examiner or coroner systems. Medical examiners-usually physicians and generally with training in pathology, medicolegal death investigation, and performance of forensic autopsies-generally have greater expertise in unnatural death investigations than do coroners. OBJECTIVE: To document the locations and implementation year for states and counties that have medical examiner systems that have replaced coroner systems or that are defined in statute and assist coroners in their investigations. DESIGN: Review of published information and national survey in 1997. SETTING: United States. PARTICIPANTS: County medical examiners and state medical examiners or their administrators. MAIN OUTCOME MEASURES: The location of states and counties with medical examiner systems, the implementation year for each system, and the proportion of counties and population served by medical examiner systems. RESULTS: A total of 79 of 91 county medical examiners responded. A total of 36 states have at least 1 medical examiner system at the county, district, or state level in which there is no coroner involved in the death investigation process. Only 22 states have medical examiner death investigation systems in place and have no coroners in the state. Among 13 states in which some counties have coroner systems and some have medical examiner systems, medical examiner systems exist in 8% of counties and serve 43% of the population. Medical examiner systems that operate without coroner involvement serve about 48% of the population nationwide. Few state or county medical examiner systems have been implemented since 1990. CONCLUSIONS: In this century, medical examiner systems have gradually replaced coroner systems, but such change has slowed in recent years, with medical examiner systems now serving about 48% of the national population.
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Antihistamines are popular nonprescription medications for the treatment of allergy and cold symptoms. Accidental exposures to these preparations are common with > 14,000 occurring annually in children under the age of 6 years (1). Despite this, there is limited information about toxic and lethal concentrations of these drugs in children. We present a case of a pediatric fatality due to a common brompheniramine and phenylpropanolamine preparation and review available Pediatric Toxicology Registry data on alkylamine antihistamines. The data collected by the Pediatric Toxicology Registry on the drug phenylpropanolamine has been previously reported (2). A review of the Registry data suggests that postmortem blood brompheniramine concentrations of 0.4 mg/L and greater in children is indicative of brompheniramine poisoning. However, pheniramine was also present in the blood in the same case and may have caused an additive effect. The data are insufficient to establish the threshold of fatal blood pheniramine concentration in children. Data for chlorpheniramine are lacking.