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Biomedical subjects

R Hampel

Publications and source records attributed to R Hampel.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Effect of thyroid hormones on noradrenaline-stimulated lipolysis in obesity].

11 extremely adipose patients were over 4 days loaded with a noradrenalin infusion of 0.1 microgram/kg body weight/minute over 60 minutes before and after a daily application of 200 micrograms tri-iodothyronine. The determination of the free fatty acids and of glycerin resulted in a significant elevation basally as well as after stimulation with noradrenalin. Thus the lipolytic influence of the thyroid hormones is confirmed under in-vivo-conditions. The possible mechanisms of lipolysis in the fatty tissue are discussed on the basis of literature.

Adolescent↗
PubMed1982

[The behavior of the thyrotropin-releasing hormone test in fasting with and without triiodothyronine administration].

It is reported on the performance of the 400 microgram TRH/TSH test in adipose persons in the course of a zero diet and on the effects of an application of 50 micrograms tri-iodothyronine during 7 days on the TRH/TSH test on the same conditions. During total fasting the basic and TRH-stimulating TSH-level shows a slight tendency of decrease, but scarcely significant changes. After application of 50 micrograms tri-iodothyronine an unequivocal suppression of the TSH-concentration in the serum is to be recognized. By these results and with the help of literary data by means of the most sensitive test of the diagnostics of hypothyroidism a general hypofunction of the pancreas could be excluded, as it was supposed in the low T3 syndrome. But tri-iodothyronine deficiency in some tissues is still discussed at present.

Adolescent↗
PubMed1982

[Results of thyroid hormone therapy in bland struma].

2,191 patients with bland struma were treated with tri-iodothyronine and a mixed preparation (thyreotom) for at least 2 years. Several clinical criteria were used for judgement. A good result could be obtained in 78.3 to 51.2% depending on the size of the struma (I-III). While in diffuse strumata good results were obtained in 87.8 to 69.0%, in nodular goitres we were successful only in 52.0-32.9%. The therapy may be successful at every age. Since with growing age the nodular goitres prevail, the chances of success become smaller. For the same reason there is a close correlation between age of the goitre and the therapeutic effect. The rate of success continuously decreases with growing age of the goitre. From this results that the therapy in goitre must begin early, before nodular and regressive changes, respectively, render the treatment difficult or render an acceptable result difficult.

Adult↗
PubMed1982

[Pulmonary fibrosis and pregnancy].

Complete pregnancy of a patient with progressive chronic interstitial pulmonary fibrosis (Hamman-Rich syndrome) is reported in this paper. One pregnancy was interrupted and the other intensively attended to up the 32nd week in which premature rupture of the membranes was followed by caesarean section and subsequent sterilisation. Reference is made to physiological and pathophysiological aspects of respiration in gravidity and in the presence of pulmonary fibrosis.

Adult↗
PubMed1981

[Alkaline phosphatase isoenzymes and hyperthyroidism].

We determined the serum total alkaline phosphatase as well as the alkaline phosphatase isoenzyme pattern in untreated and treated hyperthyreoses in the condition of euthyreosis and compared them with those of a healthy control group. The isoenzyme patterns, expressed as L/K quotient, ranged between 1.3 and 2.5 in the normal group and between 0.3 and 1.3 in the group with hyperthyreosis. The increase of the total alkaline phosphatase in hyperthyreosis was nearly exclusively conditioned by the increase of the activity of the osseous isoenzyme. The latter was increased already also then, when the total alkaline phosphatase had not transgressed the upper border of the normal. Depending on the functional condition of the thyroid gland the liver isoenzyme did not show any significant changes. In the course up to one year under thyrostatic therapy the increased activity of the osseous alkaline phosphatase decreased into the normal region as an expression of the very slowly repairing hyperthyreosis-conditioned disturbances of the osseous metabolism. An increase of the activity of the total alkaline phosphatase or of the osseous isoenzyme in the initial phase of a thyreostatic therapy of the sequel of an increase of the reactive activity of osteoblasts and must not lead to diagnostic and therapeutic uncertainties. By reason of the high sensitivity of the L/K quotient in hyperthyreoses (L/K at 95.5 % below 1.3) with a simultaneously high specifity of 89.5% the alkaline osseous phosphatase is to be discussed by all means as a helpful parameter of the peripheral function of the thyroid gland.

Alkaline Phosphatase↗
PubMed1980

[Problems of treatment with thyroid hormones. Thyroxin monotherapy or a T3/T4 combination preparation?].

At the instance of T3- and T4-measurements of the daily profile in the serum after the application of triiodothyronine and the usual T3/T4-combination preparations is referred to the unphysiologically high T3-peaks 2 to 4 hours after the application depending on the proportion of triiodothyronine. The three distributed all over the day doses of e.g. thyreotom do not sufficiently smooth such undulations. The lacking triiodothyronine serum peaks after application of pure thyroxin as a bolus confirm the demand of a thyroxin monotherapy. Nevertheless, for answering the question of the "physiologic thyroid hormone therapy" some problems remain open which are discussed. Taking into consideration these facts (particularly conversation and extrathyroid influence of the thyroid hormone metabolism) a combination of T3 to T4 in the ratio 1:10 is recommended.

Adult↗
PubMed1980

Glucose and insulin concentration patterns in cerebrospinal fluid following intravenous glucose injection in humans.

The glucose and insulin (IRI) concentration pattern in both peripheral venous blood and cerebrospinal (CSF) were studied in 10 normal weight non-diabetic subjects after glucose load of 0.33 g/kg injected intravenously. A significant increase of glucose induced IRI-response with an IRI-peak concentration after 5 min was found in the peripheral venous blood whereas no changes in both glucose and IRI-levels of the CSF occurred. The basal IRI-CSF-concentration (4.08 +/- 0.6 muU/ml) was five times lower in comparison to the level measured in the venous blood and remained unchanged over the 15 min period of observation. There were not any correlations between peripheral venous blood and CSF concerning the glucose and IRI concentration. The physiological significance of the low insulin concentration in CSF and the delay in the passage of this hormone in CSF is still unclear.

Adult↗
PubMed1979

[Behavior of the erythrocyte glucose-6-phosphate dehydrogenase in patients with functional thyroid disorders and in hyperthyroxinemic rats].

This paper deals with the activity of glucose-6-phosphate dehydrogenase in patients with hyper- and hypothyroidism as well as in hyperthyroxinaemic rats. The activity of glucose-6-phosphate dehydrogenase is enhanced in red blood cells of hyperthyreotic patients and hyperthyroxinaemic animals. The activity will be decreased to normal range in patients by administration of antithyreotic drugs, such as thiamazole. Patients with hypothyroidism exhibit decreased enzymatic activity. It is suggested that thyroid hormones stimulate the HMP-shunt in red blood cells as a defence mechanism against additional oxidative stress.

Animals↗
PubMed1978

[The problem of cardiac metastases].

Report on metastases of the myocardium of a bronchial carcinoma in a 66-year-old woman. On the basis of an own case as well as of literature the author adopts a definite attitude to frequency, localisation and diagnostics of the secondary tumours of the myocardium.

Aged↗
PubMed1976

[Sarcoidosis of the central nervous system].

Report on a 31-year-old man who fell ill from a meningoencephalitis in Boeck's disease. The course was subacute, in which case at first meningitic, later on focal encephalomeningitic symptoms stood in the first place. In the post-mortem examination a severe epitheloid-cellular granulomatosis of brain, spinal cord and their meninges was established. An affection of the lungs, of the bronchopulmonary lymphatic nodes, liver and spleen was also to be verified. It is referred to the diagnostic difficulties and the evident variability of the clinical picture of a cerebromeningeal sarcoidosis.

Adult↗
PubMed1976

[Nephrotic syndrome after treatment with penicillamine in Wilson's disease].

In a 33-year-old man with Wilson's disease a nephrotic syndrome appeared as a severe complication under penicillamine therapy. Under strong observation and exact controls of protein in the urine, leucocytes, differential blood picture and thrombocytes after interruption of the medication and retrogression of the side-effects a retarding new stabilisation of penicillamine can take place. Other side-effects of penicillamine observed as well as control measures under a long-term treatment with penicillamine are briefly discussed.

Adult↗