Auditory localization of value related material.
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Acoustic Stimulation↗
Biomedical subjects
R Hamlin
Publications and source records attributed to R Hamlin.
Hospital cost and use control via New York City health department.
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Costs and Cost Analysis↗
Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP.
The 3.3-A resolution crystal structure of the large proteolytic fragment of Escherichia coli DNA polymerase I complexed with deoxythymidine monophosphate consists of two domains, the smaller of which binds zinc-deoxythymidine monophosphate. The most striking feature of the larger domain is a deep crevice of the appropriate size and shape for binding double-stranded B-DNA. A flexible subdomain may allow the enzyme to surround completely the DNA substrate, thereby allowing processive nucleotide polymerization without enzyme dissociation.
Binding Sites↗
Novel subunit-subunit interactions in the structure of glutamine synthetase.
We present an atomic model for glutamine synthetase, an enzyme of central importance in bacterial nitrogen metabolism, from X-ray crystallography. The 12 identical subunits are arranged as the carbon atoms in two face-to-face benzene rings, with unusual subunit contacts. Our model, which places the active sites at the subunit interfaces, suggests a mechanism for the main functional role of glutamine synthetase: how the enzyme regulates the rate of synthesis of glutamine in response to covalent modification and feedback inhibition.
Adenine Nucleotides↗