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Biomedical subjects

R Hall

Publications and source records attributed to R Hall.

At least 631 records · Page 35Linked to original sources
PubMed1970

Chlordiazepoxide (Librium) and tests of thyroid function.

The effect of chlordiazepoxide (Librium) on thyroid function was examined in 14 euthyroid patients who required the drug for psychiatric reasons and in six patients with clinically mild thyrotoxicosis. There was no significant difference in results from tests of thyroid iodide trapping (thyroid radioiodine uptake, thyroid clearance, and absolute iodine uptake) or of thyroid hormone release (protein-bound iodine, T3 resin uptake, and free thyroxine index) carried out before and during treatment with the drug over a four-week period. It is suggested that chlordiazepoxide need not be withdrawn before thyroid status and function are assessed in any patient taking the drug.

Adult↗
PubMed1970

Thyroid-stimulating hormone response to synthetic thyrotrophin releasing hormone in man.

Synthetic thyrotrophin-releasing hormone, L-pyroglutamyl-L-histidyl-L-proline-amide, has been administered intravenously to euthyroid subjects in doses ranging from 1 to 200 mug. Its effect was assessed by serial measurements of serum thyroid-stimulating hormone (T.S.H.). A rise in serum T.S.H. was detectable five minutes after administration of 50 mug. of thyrotrophin-releasing hormone, reaching a maximum in 15 to 30 minutes, and then gradually declining over the next 120 minutes. Doses of 100 and 200 mug. of thyrotrophin-releasing hormone produced even greater rises of T.S.H. in some cases. The only side-effect noted was transient nausea with doses greater than 50 mug. Measurement of serum T.S.H. levels after administration of thyrotrophin-releasing hormone should prove a useful test of pituitary T.S.H. release and may help to distinguish pituitary and hypothalamic lesions.

Adult↗