[Anginal attacks without electrocardiographic changes: a new entity in coronary disease patients?].
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Biomedical subjects
Publications and source records attributed to R Haiat.
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Of 123 healthy pregnant women (mean age 28 yrs) who have been studied at various stages of their gestation by Tm and two dimensional echocardiography, 46 were in their late pregnancy (32nd to 38th week of pregnancy). Echocardiograms showed definite signs of pericardial effusion (PE) in 19 of those 46 women: the effusion was large in two, moderate in four and small in thirteen cases. PE was clinically silent as neither precordial pain nor pericardial friction rub was present. In all cases, pregnancies were uncomplicated; clinical examination was normal; however blood pressure was slightly elevated in three women. The electrocardiogram was normal or showed non specific ST-T change. PE appeared in the late pregnancy and did not occur before the 32 nd week; it was always transient and could not any longer be seen within the two months following delivery. It was likely to result from water and salt inflation as the mean weight gain was significantly higher in the group of women with PE. PE has not been reported so far during normal pregnancy. Echocardiography affords a safe and reliable approach of its diagnostic.
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In the purpose of studying their respective predictive value, beside the cardiovascular risk, the concentrations of B and (Apo) A1 apoproteins, cholesterol, triglycerides, LDL-cholesterol and HDL-cholesterol were estimated in a group of 110 patients (acute coronary insufficiency : 30 cases; recent myocardial infarction : 50 cases; cerebro-vascular accident : 30 cases) compared with the concentrations of an example group composed of 150 normolipemic subjects, presumed healthy. The concentrations of Apo A1 and HDL-cholesterol remain close in both groups, respectively to 1,6 +/- 0,33 mmol/l and 0,85 +/- 0,18. On the other hand, in the patients group, the concentrations of LDL-cholesterol, triglycerides and cholesterol are very increased in all the patients less than 60 years old; beyond they meet the ones of the control subjects with same age; the concentrations of the Apo B stay high in all the cases. In conclusion, the predictive value of the concentrations of HDL-cholesterol and of the Apo A1 remains very uncertain; it's much lower than the value of the concentrations of Apo B, major protein constituent of the atherogenic lipoproteins which are increased significantly whatever may be the age of the patient who show acute vascular accident linked to the atherosclerosis.
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The authors report the case of anteroseptal myocardial infarction, complicated by a late pericardial reaction (5th - 10th week), the development of an aneurysm, and, above all, refractory ascites (12th week) found to be secondary to constrictive pericarditis. Pericardectomy and partial resection of the aneurysm were performed. Constrictive pericarditis is rare after myocardial infarction and its relationship to a forme fruste of Dressler's syndrome remains uncertain. The pathogenesis of the constriction is unknown. This complication (only reported once previously) should be recognised because of the surgical management it implies.
In 40 hypertensive patients continuous ECG recording was done before and after 30 days treatment with indapamide 2.5 mg. There was no change in heart rate. In addition, the incidence of extrasystoles was not changed in patients in whom the ECG was normal before treatment (30 cases) or in 8 of the 10 patients who had an incidence of more than 1% extrasystoles. However, in the other 2 patients who presented with an incidence of more than 1% extrasystoles the incidence of extrasystoles rose.
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Postero-inferior-myocardial-infarction (MI) results usually from the occlusion of the right coronary artery. Recent pathological and angiographic studies have pointed out that in such cases occlusion of the right coronary artery was often (30 to 80 per cent of cases) associated with a severe (greater than or equal to 70 %) stenosis of the left anterior descending coronary artery. Thus, serious left coronary artery disease is frequent and unrecognized in patients with chronic even uncomplicated MI. Exercise test does not allow to recognize accurately this high risk group of patients which should be identified by coronary arteriography.
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The authors report three cases of full term pregnancies, without complications, in women with isotopic pacemakers. The newborn infants were normal. In one case, pregnancy occurred in a patient who already had a pacemaker. In two cases, the pacemaker was inserted during pregnancy (at 1 and 1/2 and 5 months respectively), in the treatment of syncopal attacks due to paroxysmal atrioventricular block. This type of pacemaker using a radioactive source (Plutonium 238) is, by virtue of the low degree of radiation, harmless and may be used in women of childbearing age. Under the least favourable conditions (pacemaker box in abdominal situation), the dose delivered during pregnancy (57 mrem) is approximately 20 times less than the authorised dose (1125 mrem).
The authors report 26 cases (average age 69 years) of stage IV atheroma of the leg arteries for which a conservative surgical operation was attempted. Aortography (18 times) or femoral arteriography (8 times) were performed without difficulty before operation. During the same operation, a single procedure was performed in 15 cases, 2 or 3 procedures were performed in 11 cases. Thus were carried out: sympathectomy in 7 cases, endarterectomy in 8 cases, a by-pass operation in 23 cases. There were 4 deaths (15%) during the postoperative period. In 18 of the 22 patients who survived the operation, trophic disorders completely disappeared, and the functional result assessed with an average follow up of 15 months (1 to 25 months) on the degree of intermitent claudication was judged good or very good in 16 cases, mediocre in 2 cases. In 4 of these 22 patients, the trophic disorders persisted or reappeared in the short term and amputation was then carried out in 3 of these 4 cases. Conservative surgery remains possible and useful in stage IV arterial disease of the lower limbs. It is however important to operate early in the course of the disease after failure of adequate medical treatment.
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The authors report the cases of 7 patients with a normal basal electrocardiogram, whereas they were all affected with a high risk cardiovascular condition: coronary insufficiency in 3 cases, paroxysmal arrhythmia in 4 cases. They recall the limits of the conventional ECG and emphasise interest of dynamic recordings, with effort tests, and/on continuous ECG recording in the identification of certain transient heart manifestations.