Biomedical subjects
Publications and source records attributed to R Haddad.
In an 11-year-old girl the left eye developed a sclerocorneal cyst seven years after a bilateral squint operation. The cyst was excised and a lamellar corneal graft was performed. Histopathology revealed a cyst formed by nonkeratinizing stratified squamous epithelium.
Report on a 69-year-old woman with a choroidal and a large peribulbar tumor. A scan ultrasonography of the peribulbar mass revealed a homogeneous structure of the lymphoma/sarcoma/pseudo-tumor type. Histological examination disclosed a reactive lymphoid hyperplasia without "Dutcher bodies", and consistent with a benign lymphoma.
The gelatinous cystic nevus is both histologically and biomicroscopically a very typical form of conjunctival venus. A report on two cases serves to illustrate the indications for an operative procedure. In one case an incisional biopsy was performed, in the other an excisional biopsy. In neither case was there any histological evidence of malignancy.
Report on clinical and histopathological changes of the conjunctiva after long-term use of cosmetics containing carbon black (mascara, eyeliner) on the lid margin. Penetration of tiny pigmented particles into the stroma of the conjunctiva initially causes a follicular reaction which is evidently toxic, and later, results in a chronic follicular-papillary reaction.
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In 18 rabbits a mixture of 131-J-labeled Triolein and purified olive oil was injected intravenously. Afterwards the radioactivity of the eyes and the brain was measured. The relation of distribution of fat between eye and brain differs markedly, even when the surface tension was controlledly altered by admission of essential phospholipids.
Prostaglandin mediated transient increase in intraocular pressure following cryokoagulation of the ciliary body in rabbits was completely inhibited by preoperative administration of Aspisol (D, L-Lysin-mono-(acetylsalicylat)). To avoid additional increase in intraocular pressure in patients chosen for cyclocryotherapy, pretreatment with Aspisol could prove to be effective.
Report on a benign epithelioma of the ciliar body which caused cataract and dislocation of the lens in a 44-year-old woman. Tumour seeding was a remarkable finding, and is a result of disruption of the epithelial lining due to active production of mucopolysaccharides by tumour cells.
Report on massive deposition of calcium hydroxypatite in the eye of a 20-year-old woman who died as a result of chronic renal failure. Massive accumulation of this material within the previtreal space lead to an unusual finding in the peripheral fundus.
5 1/2 years after excision of pigmented malignant melanoma which apparently arose in a nevus of the paralimbal bulbar conjunctiva, this 42-year-old male presented himself with a nonpigmented mass of the lid margin which also proved to be a malignant melanoma. "Acquired melanosis sine pigmento" was considered as a site of origin, but histopathologically there is more evidence that this melanoma arose in a non-pigmented compound nevus.
Doppler Ultrasonography of the orbital vessels is a simple non invasive technique for the qualitative determination of velocity and direction of blood flow within the supratrochlear and supraorbital arteries. In temporal arteritis characteristic findings can be obtained with this method. The amplitudes of ultrasonograms are markedly reduced and the waveforms considerably distorted. Sometimes there is a complete absence of velocity signals from the orbital vessels. When the superficial temporal artery is compressed abnormal reactions are almost always elicited, whereas the compression of the homolateral carotid artery yields normal results. In temporal arteritis, the diagnostic value of Doppler ultrasonography of orbital vessels seems about as great as that of Hager ophtalmodynamography.
In human fat embolism we often find different grades of changes in both eyes of a patient. This was experimentally verified in rabbits. The anesthetized animals were held in lateral position so that one eye was continuously higher than the other. Labelled fat was injected intravenously, and then the activity in each eye was measured by a scintillation-counter. By this method a significantly higher rate of fat embolism was found in the upper eye.
A 68-year-old man presented with a rapidly growing upperlid tumor which due to multiple recurrences was excised 5 times within 4 years; and ultimately invaded the orbit. An orbital exenteration was performed. The unusual clinical course and the A-Scan sonographical findings of this tumor were most probably due to its uncommon histological features which proved to be an undifferentiated squamous cell carcinoma with features of Epithelioma metatypique intermediaire Darier.
Two patients with a superficial variant of granular dystrophy of the cornea occurring primarily in nongrafted eyes developed rapid progression of clinical manifestations and visual deterioration at an early age. No other members of their family were known to be affected. A clinical diagnosis of superficial corneal dystrophy, type undetermined, was made. The histopathologic features of the corneas resembled the findings seen in Reis-Bücklers dystrophy and led to some confusion in the differential diagnosis. Electron microscopic studies in both cases unequivocally established the diagnosis of granular dystrophy.
An infant who was the product of a full-term pregnancy was born with multiple congenital defects, including diffuse bilateral corneal opacification. He failed to thrive and died at the age of 4 days. Autopsy findings were consistent with those seen in the cerebro-hepato-renal syndrome. Histopathologic examination of both eyes, obtained at autopsy, demonstrated similar changes. The main pathologic findings in the anterior segment were bilateral, diffuse corneal edema associated with paracentral iridocorneal adhesions and focal attenuation of Descemet membrane. Both retinas disclosed a selective degeneration of the outer nuclear layers and photoreceptors, confined mainly to the macular region. Atrophy of the optic disc and nerve, with reactive gliosis and demyelination, were consistent with findings in the central nervous system described in this syndrome.
Young ferrets (6 and 10 weeks old at the start of the experiments) were compared to adult ferrets on learning (1) a Lashley III maze, (2) a left-right discrimination in T-maze with identical choice arms, and (3) a reversal of the left-right discrimination. The young were not inferior to the adults in learning either the Lashley III maze or the initial discrimination in the T-maze. However, the young were markedly (and significantly) inferior to the adults in learning to reverse.
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