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R H Walker

Publications and source records attributed to R H Walker.

96 records · Page 6Linked to original sources
PubMedDate not supplied

Rh immune globulin and the Rh-positive Du variant, mother.

Questions have been raised by statements of the American College of Obstetricians and Gynecologists that Rh immune globulin should be given to all Rh positive, Du variant, mothers who have recently delivered Rh positive infants. This practice is not recommended. However, blood banks must assure that a positive Du test on a mother's blood sample is not caused by a massive fetal-maternal hemorrhage. Failure to recognize this cause of a positive Du test may result in the administration of an inadequate dose of Rh immune globulin.

Female↗
PubMedDate not supplied

The probability of exclusion of the HLA-A,B system in North American whites and blacks in parentage tests.

The value of the HLA-A,B system in excluding a man falsely accused of paternity, the power of exclusion (A), was examined by four different methods. Methods to define A were: analysis of artificially created false trios, calculation of the proportion of all exclusion cases (corrected for unexcluded men who were not fathers) in which the HLA system showed evidence of an exclusion, derivation from individual Random Man Not Excluded (RMNE) values, and derivation from individual Paternity Index (PI) values. The false trios were limited within the same ethnic group (whites and blacks) so that no mixed ethnic matings were considered. It was assumed that all of the men in the artificial trios were not fathers. Twenty-one percent of the observed exclusions were based on A locus markers, 36 percent on B locus markers, and 43 percent on both A and B markers. Among 510 false white trios, the man was excluded in 476 cases, yielding a power of exclusion (A) for whites of 93.3 percent. One hundred thirty men were excluded in 140 black artificial trios, giving a value of 92.9 percent for A in blacks. Similar values, 94.4 percent for whites and 93.6 percent for blacks, were derived from the proportion of all exclusions detected by the HLA system. A was also derived by computer analysis on the same cases with formulas that use RMNE and PI values. These results also agreed. This concordance by all four methods enhanced the validity of the A values of about 93 to 94 percent for both whites and blacks.(ABSTRACT TRUNCATED AT 250 WORDS)

Black People↗
PubMedDate not supplied

Erb, an allele to Era, and evidence for a third allele, Er.

An antibody against a low-incidence antigen was detected in the serum of a woman whose newborn infant was found to have a positive direct antiglobulin test. The antibody failed to agglutinate 79 examples of red cells having low-incidence antigens and 16 examples of high-incidence antigen-negative red cells. The woman's serum reacted strongly with her husband's red cells in the antiglobulin test and with 5 of 6 Er(a-) cell samples from unrelated donors, suggesting that the antigen has an antithetical relationship to Era. The failure of the serum to react with one Er(a-) cell sample and with cells from the Er(a+) daughter of an Er(a-b+) mother gives evidence for a silent allele, Er. Four Er(b+) bloods were found among 605 random white donors, indicating a gene frequency for Erb of 0.0033.

Adult↗