A multiple chamber exposure unit designed for chronic inhalation studies.
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Biomedical subjects
Publications and source records attributed to R H WILSON.
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A series of patients with chronic respiratory insufficiency were treated with intermittent positive pressure breathing, which was combined with administration of bronchodilator drugs of the epinephrine series. Spirographs were made before and after treatment. The series included patients with chronic bronchitis and emphysema, fibrosis of various kinds, senile emphysema and bronchogenic carcinoma. Although the majority showed objective improvement, a significant proportion in all groups did not, and some were made worse, apparently on a basis of check valve mechanisms unresolved by the bronchodilator drug. In cases in which the method benefited the patient, the benefit was greater than that obtained with bronchodilator drugs alone.
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Asthma and chronic bronchitis are characterized by bronchial occlusion in expiration. Acute spasmodic asthma, if prolonged, may bring about changes in thoracic structure and diaphragm position which can result in permanent pulmonary inefficiency unless this tendency is corrected by breathing exercises. As expiratory obstruction becomes more chronic, irreversible emphysema develops. Thereafter therapy for bronchopulmonary insufficiency is necessary. The approaches to such therapy have been outlined and briefly evaluated, with emphasis upon the value of intermittent positive-pressure therapy.
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