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Biomedical subjects

R H Thompson

Publications and source records attributed to R H Thompson.

At least 55 records · Page 3Linked to original sources
PubMed1989

Prefrontal projections to the medial nuclei of the dorsal thalamus in the rabbit.

Retrograde transport of horseradish peroxidase (HRP) from the mediodorsal (MD), ventromedial (VM), ventroposterior (VP) and intralaminar (IL) nuclei of the dorsal thalamus revealed a topographical pattern of efferents from the frontal cortex. MD injections labeled the midline and insular regions of the prefrontal cortex (Pfc), including the anterior limbic, and most ventral part of the precentral agranular Pfc, as well as the agranular insular cortex. VM injections labeled only the most dorsomedial part of the granular insular cortex, whereas IL and VP injections labeled the dorsal precentral agranular Pfc and a strip of cortex that extended laterally across the superior aspect of the forceps minor. The IL injections also labeled cells that extended ventrally into the granular and agranular insular areas.

Animals↗
PubMed1988

From questions to answers: approaches to studying play in health care settings.

Although play has long been considered an important factor in humanizing health care environments for children, research investigating the role of play in pediatric settings has been limited, a condition that may be attributed to practitioners' unfamiliarity with techniques for studying play. Methods of conducting play research to provide systematic descriptions of play activities and to examine relationships between play and other factors are discussed.

Child↗
PubMed1988

Relationship between delta-9-tetrahydrocannabinol-induced arachidonic acid release and secretagogue-evoked phosphoinositide breakdown and Ca2+ mobilization of exocrine pancreas.

We have previously shown that addition of exogenous arachidonic acid to pancreatic acinar cells inhibits the incorporation of myo-[3H]inositol into membrane phosphoinositides and causes a reduction in the steady state levels of [32P]phosphatidylinositol-4,5-bisphosphate (PtdIns4,5P2). In the present study, delta-9-tetrahydrocannabinol (THC) was utilized to raise endogenous levels of arachidonic acid. In acinar cells simultaneously prelabeled with [3H]arachidonic acid and [32P]Pi, THC (1-20 microM) produced a concentration-dependent increase in free [3H]arachidonic acid release and a reduction in the steady state levels of [32P]Ptd-Ins4,5P2. THC (1-20 microM) also caused a concentration-dependent inhibition of myo-[3H]inositol trisphosphate accumulation, cytoplasmic Ca2+ level, and amylase secretion elicited by 0.1 microM caerulein. The findings that THC (20 microM) was unable to inhibit either the rise in [Ca2+]i elicited by ionomycin, or the secretory response to phorbol myristic acid or ionomycin, indicate that THC exerts a selective inhibitory effect on the phosphoinositide messenger system. These results support the postulate that endogenous arachidonic acid serves as a negative feedback regulator of phosphoinositide turnover in exocrine pancreas.

Amylases↗
PubMed1988

Child life.

Explore the source record for details and available documents.

Child↗
PubMed1986

Where we stand: twenty years of research on pediatric hospitalization and health care.

The results of a major review of the literature on the psychosocial implications of pediatric hospitalization and health care, covering more than 300 research reports appearing since 1965, are summarized. Among the topics addressed are children's responses to hospitalization, the effects of separation and parental rooming-in, parental responses to hospitalization, the hospital environment, play, and preparation. Suggestions for future research are also discussed.

Adaptation, Psychological↗
PubMed1981

Showing them what you can do: a practical guide for evaluating child life programming.

To successfully compete with other services for scarce hospital funds, Child Life professionals must be able to demonstrate accountability through competent program evaluation. In addition to the function of assessing the achievement of programs goals, evaluation offers an opportunity to educate supervisory personnel by indicating: (1) the value of the services offered, (2) the competence of Child Life personnel and their concern for quality, and (3) the need for additional hospital support. Guidelines for conducting and submitting an evaluation and the relationship between evaluation and the promotion of Child Life goals are discussed.

Child↗
PubMed1980

Furcation involvement in maxillary and mandibular molars.

This is a sequel to a previous study that showed that many molars with furcation involvement (F.I.) can survive in a state of health and can function efficiently and without pain for many years. This finding is at variance with the views of others who believe that the prognosis for teeth with F.I. is unfavorable. The conclusions of the present study are: (1) F.I. of molars was a common finding; it occurred much more frequently than anticipated. (2) F.I. occurred three times more frequently among maxillary molars than among mandibular molars. (3) Many molars with F.I. functioned well from 5 to 24 years. (4) Based on these findings, it is suggested that two aspects of molars with F.I. be reevaluated, i.e. their prognosis and treatment. Further it is suggested that therapy for these teeth be designed to improve their functional environment and that in many instances removal of root or bone or extraction of the tooth is not necessary. (5) F.I. was detected more frequently in maxillary molars by radiographic examination than by clinical examination. On the other hand F.I. was detected more frequently in mandibular molars by clinical examination than by radiographic examination.

Adult↗
PubMed1979

Angina, aortic stenosis and coronary heart disease.

The pre-operative clinical and haemodynamic findings of 139 consecutive patients with aortic stenosis were analysed in an attempt to determine the incidence and influence of coronary heart disease on the mode of presentation of patients with aortic stenosis. The overall incidence of coronary heart disease was 32%. 105 patients (76%) presented with angina and of these, 41 patients (39%) had significant coronary heart disease as compared to 4 (13%) of the remaining 34 patients who did not present with angina. Clinical parameters including age, sex, severity of angina together with the presence of associated symptoms and precipitating factors were unhelpful in distinguishing those patients with coronary heart disease. Evidence of previous transmural myocardial infarction or the presence of ST-T abnormalities in the absence of digitalis and the changes of left ventricular hypertrophy were reliable electrocardiographic signs of coronary heart disease. Although peak systolic aortic valve gradient tended to decrease with increasing severity of coronary heart disease, the severity of aortic stenosis was not a reliable indicator of the presence of coronary disease. Patients with coronary heart disease in the absence of angina all had a combination of moderate aortic stenosis and single vessel disease. It is concluded that coronary heart disease cannot be predicted in patients with angina and, in the absence of angina occurs with an incidence sufficiently high to advocate the use of coronary angiography as part of the investigation of all patients with aortic stenosis being considered for valve replacement.

Adult↗
PubMed1978

A long term study of root retention in the treatment of maxillary molars with furcation involvement.

A study was done to evaluate long-term results of treating 387 maxillary molars with furcation involvement in 100 patients with chronic destructive periodontal disease. Results showed a favorable long term functional survival rate of 341 teeth (88%) 5 to 24 years after treatment, despite the fact that many teeth had at least one root with 50% or less of bone support before treatment. Of the 46 teeth (12%) that were ultimately extracted, 25 were present for a significant length of time (6 to 18 years) before extraction. The radiographs of 292 teeth (75%) showed no significant change in bone support 5 to 24 years after treatement, while those of 8 teeth (2%) suggested improvement. There was perceptible increase in bone loss in 41 teeth (11%). Forty-six (12 %) were extracted. All periodontally involved teeth in each patient of the study were treated. Specific treatment for maxillary molars with furaction involvement included soft tissue therapy; coronal reshaping, if indicated; and instruction in home care. Considerable emphasis was placed on improving occlusal function. In no case was root amputation, hemisection, osseous surgery, or reshaping of the cervical area of the tooth done. A total of 366 (94%) of the teeth did not have endodontic therapy before, during, or after the study. Therefore endodontic therapy was not a significant factor in retention of the 341 teeth.

Adult↗
PubMed1977

Hypothalamic dysfunction in secondary amenorrhea associated with simple weight loss.

We tested hypothalamic, pituitary and endocrine function in 19 patients with secondary amenorrhea associated with simple weight loss who did not have anorexia nervosa to evaluate the effects of weight loss on these systems. Thermoregulation at 10 degrees C and 49 degrees C was abnormal and correlated with the percentage below ideal body weight (r = 0.62, P less than 0.02, and r = 0.55, P less than 0.05, respectively). Partial diabetes insipidus was found in 27 per cent of patients with simple weight loss. They had delayed peak plasma luteinizing hormone levels after 10 microgram of luteinizing-hormone-releasing factor, which was correlated with percentage below ideal body weight (r = 0.49, P less than 0.05). Delayed peak plasma thyrotropin levels after 500 microgram of thyrotropin-releasing factor were found. No prolactin, pituitary, thyroid or adrenal abnormalities were present. These findings are qualitatively similar to results of studies in 29 patients with anorexia nervosa, but less severe and less frequently present. We conclude that hypothalamic dysfunction may be caused by weight loss per se.

Adolescent↗
PubMed1976

The copper status of beef cattle in Northern Ireland.

1. Serum caeruloplasmin (ferroxidase I;EC 1.16.3.1) activity has been used as an indicator of copper status of cattle to survey beef herds in Northern Ireland. 2. The main survey covered some 20 000 cows on 1200 farms. 3. The results are reported in the form of a map showing area where herds of low and very-low Cu status predominate. Clinical signs of Cu deficiency in calves were encountered in only two areas.

Animals↗
PubMed1976

Genesis of the sweat:plasma urea concentration gradient.

Experiments with 14C-labeled urea in human volunteers show that urea is sequestered in the epidermis, where it turns over more slowly than in general body water. Sequestered urea, presumed to be concentrated through insensible evaporation of water, is the source of the excess urea found in sweat. Physiologic and clinical implications of the existence of this urea pool are discussed.

Clinical Trials as Topic↗
PubMed1976

Relationship between plasma and lymphocyte linoleate in multiple sclerosis.

The linoleate level in total lipids was measured in lymphocytes from control subjects and patients with multiple sclerosis. A small but significant decrease was found in cases of multiple sclerosis. The percentage composition of lymphocyte fatty acids was determined in rats fed diets with various linoleate contents. There was a correlation between lymphocyte linoleate and plasma linoleate in both humans and rats.

Animals↗
PubMed1976

Role of pentose-phosphate pathway in haemolytic crisis of chronic copper toxicity of sheep.

Although the rise in blood copper is associated with onset of the acute haemolytic crisis of chronic copper poisoning in sheep, the sudden fall in erythrocyte glutathione is apparently not due to a direct action of the copper. Moreover the reduced glutathione of the red cells is converted to some form that is not capable of regeneration by the pentose-phosphate mechanism. Only negligible inhibition of the pentose-phosphate enzymes occurs. As the haemolysis proceeds, there is a rapid recovery of erythrocyte glutathione levels, and a marked increase in pentose-phosphate enzyme activity, consistent with influx of young red cells. It seems that the release of copper into blood from liver at the haemolytic crisis is associated with an increase of the oxidative state of the blood, possibly by simultaneous release of other components from the liver.

Animals↗