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Biomedical subjects

R H Thomas

Publications and source records attributed to R H Thomas.

At least 55 records · Page 3Linked to original sources
PubMed1987

Prolonged increase in digital blood flow following iloprost infusion in patients with systemic sclerosis.

Thirteen patients with Raynaud's phenomenon secondary to systemic sclerosis received three 8-hour infusions of a synthetic prostacyclin analogue (Iloprost) on consecutive days and were followed-up over a period of 10 weeks during the winter of 1985/86. Six weeks after infusion, digital peripheral vascular resistance had fallen (P less than 0.05) and dicrotic notch proportion of pulse amplitude increased (P less than 0.05). Digital blood flow and pulse amplitude (measured by photoplethymography) were also increased but did not reach statistical significance. The trend of improvement in these blood flow parameters was still evident after 10 weeks. The number of cutaneous lesions (digital ulcers, etc) fell from 26 lesions before infusion to only 7 lesions by the end of the study, confirming the subjective improvement reported by the patients.

Adult↗
PubMed1987

Acquired immune deficiency syndrome without the recognized risk factors.

We report two cases of acquired immune deficiency syndrome (AIDS), apparently without the usual exposure factors, in whom a temporal association was detected after detailed epidemiological investigation. The index case, a 45 year old housewife, had provided terminal home-nursing care for a 33 year old African man, who died from an undiagnosed encephalitis. At that time she had fissures of the skin of both her hands. Review of post-mortem pathology specimens of the African man allowed a retrospective diagnosis of AIDS with cerebral toxoplasmosis to be made. The type of home-nursing care given by the index case was quite different from that normally provided by health care workers with the training and facilities to prevent the spread of infection.

Acquired Immunodeficiency Syndrome↗
PubMed1986

Polysulfone corneal lenses.

Polysulfone is a thermoplastic compound first synthesized in 1965. A unique characteristic of polysulfone is its high refractive index (1.633), which allows very thin optical lenses to be manufactured. Over the last five years, D. Peter Choyce has surgically implanted over 40 polysulfone lenses into eyes of his patients. Analysis of his data indicates that polysulfone intraocular lenses are capable of correcting large refractive errors. Based on his work, a multicenter study was undertaken to evaluate the safety and efficacy of polysulfone as an intracorneal lens material in laboratory models. Four monkeys, eight baboons, and 24 cats were used as laboratory models; 5.0-mm to 6.0-mm diameter hyperopic (+28.5 diopter) and myopic (-17.0 and -25.5 diopter) lenses were surgically implanted within the corneal stroma in one eye of each of the laboratory models while a sham lamellar dissection was performed in the other eye. One hundred percent (4/4) of monkey eyes, 12.5% (1/8) of baboon eyes, and 70.0% (18/24) of cat eyes maintained clear media by ophthalmoscopic examination at follow-ups ranging from three to six months. Complications included both visually and nonvisually significant interface opacities, lens extrusion, anterior corneal necrosis, refractile particles, and epithelial thinning.

Animals↗
PubMed1986

Fixed drug eruption due to paracetamol.

A patient who developed a fixed drug eruption due to paracetamol is reported. There is only one previous account of this eruption occurring as a consequence of paracetamol therapy.

Acetaminophen↗
PubMed1985

The influence of ranitidine, alone and in combination with clemastine, on histamine-mediated cutaneous weal and flare reactions in human skin.

Significant, (P less than 0.05) inhibition of histamine induced cutaneous weal and flare reactions by ranitidine at 10(-5) M concentration has been demonstrated in a double blind, in vivo study; the results support the evidence for cutaneous H2-histamine receptors provided by previous studies using cimetidine and metiamide. The degree of inhibition of histamine mediated cutaneous reactions achieved by clemastine was increased by the administration of clemastine and ranitidine together, for ranitidine concentrations 10(-5) M (P less than 0.001) and 10(-6) M (P less than 0.05). The magnitude of the inhibitory effect of ranitidine, both administered alone and in combination with clemastine, suggests that in the production of histamine induced cutaneous weal and flare reactions, the contribution afforded by stimulation of cutaneous H2-histamine receptors is only small.

Adult↗
PubMed1985

Plasma or serum from patients with systemic sclerosis alters behaviour of normal erythrocytes.

Incubation of washed normal erythrocytes with fresh or frozen plasma or serum from patients with systemic sclerosis (SS) significantly decreased the filterability of the cells, whereas the incubation of homologous normal serum or plasma with washed erythrocytes did not alter the filterability of these cells. The endothelial cell adherence of normal erythrocytes was increased by 3.5- and 2.6-fold (p less than 0.01) respectively when plasma or serum from patients with SS rather than that from normal controls was added to the incubation medium. Further investigation and isolation of the reactive material(s) present in the serum and plasma of patients with SS, which affect the deformability and endothelial cell adherence of erythrocytes, may be helpful in understanding the pathogenesis of the disease.

Adult↗