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Biomedical subjects

R H Sagerman

Publications and source records attributed to R H Sagerman.

At least 55 records · Page 3Linked to original sources
PubMed1980

Radiotherapy for carcinoma of the nasal cavity.

Twenty-five patients with primary epithelial carcinoma of the nasal cavity without nodal or distant metastases were treated by irradiation between 1967 and 1978. Small field, beam-directed techniques delivered 6,000 to 7,000 rads with conventional fractionation. Control of the primary tumor was achieved in 21 (84%) patients after irradiation. All five treatment failures (one infield only, three infield recurrence with lymph node metastases, and one regional cervical node metastasis) were evident within six months; all five patients died of cancer. The adjusted actuarial survival rate at three years was 76%. Failure in the untreated neck was only 5% when the primary carcinoma was controlled and 16% overall. The literature has been reviewed with attention to tumor control rates and survival.

Adenocarcinoma↗
PubMed1980

External irradiation for malignant thyroid tumors.

Thirty-eight patients with residual or recurrent primary thyroid cancers which did not take up 1-131 were treated with external beam irradiation. Excluding 5 patients with malignant lymphoma, there were 23 patients with local disease and 10 with distant metastases. Doses ranged from 3,500 to 7,000 rads (35-70 Gy) among the 23 with local disease; local tumor control was achieved in 8. Six are alive and well 2-11 years later. External beam irradiation should be considered in locally advanced, incompletely resected, recurrent and metastatic thyroid malignancies of all histological types without 1-131 uptake. Reviewed are the age and sex distribution, histology, stage, extent of surgery, and dose and radiotherapy technique as they affect survival and patterns of failure.

Adenocarcinoma↗
PubMed1979

Treatment of endometrial cancer in a regional radiation therapy center: analysis of 379 consecutive patients.

Three hundred seventy-nine consecutive patients with adenocarcinoma of the corpus uteri, in whom irradiation was part of the treatment, were reviewed. The minimum follow-up was 3 years and none were lost. An increased incidence of corpus cancer in Central New York was demonstrated but could not be attributed to estrogen usage. There were 310 patients in FIGO stage I and 40 in stage II. Adenocarcinoma was reported in 319 and adenoacanthoma in 45. Overall survival was 74% and 62% at 5 and 10 years, respectively, and in stage I, 82% and 68%, respectively. Results for adenoacanthoma were similar to those for adenocarcinoma. Ten year survival was significantly better in those patients with a histologically negative hysterectomy specimen after preoperative intracavitary irradiation than in those with residual cancer. Treatment was tolerated well. This study demonstrates the results which can be obtained in a regional radiation therapy center serving patients and gynecologists from a wide geographic region operated upon in many different hospitals.

Adenocarcinoma↗
PubMed1979

Irradiation of primary brain-stem tumors.

Of 40 patients treated for brain-stem tumors, 20 had lesions of the thalamus and midbrain (group A) and 20 had lesions of the pons and medulla (group B). Performance status measured 1 month after irradiation improved in 16 of 20 group A and 11 of 20 group B patients and was a valuable prognostic factor. The survival rate at 5 years was 40% (8/20) in group A and 30% (6/20) in group B. All recurrences appeared within 3 years and were predominantly locoregional. Treatment factors, including dose and field size, are analyzed.

Adolescent↗
PubMed1979

High dose preoperative irradiation of the lower neck and supraclavicular fossae.

Preoperative irradiation of 5,000 rad in 5 weeks before total laryngectomy with radical neck dissection was compared for two groups of patients: (1) those treated to a smaller volume through lateral opposed fields (37 patients) and (2) those treated to a larger volume by adding a third field directed to the lower neck and supraclavicular fossae (46 patients). There were no significant differences in tolerance to irradiation or in postoperative complications. However, locoregional tumor control improved significantly from 63% to 90% (P less than 0.02) with the three-field technique, and all four stomal recurrences were in the two-field group. Deaths from intercurrent disease and from distant metastases without local recurrence account for the failure to improve the overall survival rate.

Adult↗
PubMed1978

Voice change after radiotherapy. Some preliminary results.

A one-third octave spectral analysis was performed on two sentences spoken by 5 patients with laryngeal cancer, 5 with head/neck cancer not involving the vocal cords, and 12 normal subjects. Recordings were made prior to and at weekly intervals during radiotherapy as well as at periodic intervals post-treatment. Patients with laryngeal cancer exhibited lower spectral levels than normal throughout radiotherapy as well as several months post-treatment. By one year after treatment, the spectral levels of these patients were largely in the normal range. Patients with head/neck cancer not involving the vocal cords exhibited greater than normal sound pressure levels throughout most of the spectrum. These levels remained high even at one month post-treatment. Irradiation of normal vocal cord tissue also seems to result in higher spectral levels.

Aged↗
PubMed1978

Complications of high dose preoperative irradiation for advanced laryngeal-hypopharyngeal cancer.

The authors studied 162 patients with advanced cancer of the laryngopharynx who were treated over the same period of time by standard techniques. High dose preoperative supervoltage irradiation to 5000 rads/5 weeks through large opposed lateral fields and a lower anterior neck field is not accompanied by a prohibitive increase in mortality or morbidity for patients with stage III-IV largynogopharyngeal cancer. Rescue surgery for recurrence after definitive irradiation can be accomplished.

Adult↗
PubMed1975

Late recurrence in medulloblastoma.

The authors present 3 cases of recurrence of medulloblastoma at 6 years, 6 years 7 months, and 7 years 4 months disease-free intervals from the time of diagnosis. Two of these cases have violated Collins' rule of survivorship; i.e., an interval longer than the patient's age plus 9 months being equivalent to cure. Two of the cases were biopsy proven recurrences of medulloblastoma and in the third, the recurrence was diagnosed on the basis of clinical and roentgenographic data. Other than for these late recurrences, our series is similar to other series reported in the literature.

Adolescent↗