Oxandrolone therapy of children with uncomplicated growth retardation caused a marked increase in penile growth. The penile length percentile also showed a significant increase at the end of the therapy. Although the older boys fell into lower percentiles than the younger boys, it appears that they showed significant penile catch-up growth. Oxandrolone therapy did not appear to cause testicular growth impairment in the majority of the boys but in a few there was a temporary delay in growth.

Adolescent↗

PubMedDate not supplied

Gynaecomasty as the first manifestation of sexual precocity (case report).

We report on a young boy who developed gynaecomastia 15 months before he showed clinical manifestations of sexual precocity. He was treated with medroxyprogesterone acetate with good results. His development to adulthood is presented. The causes of gynaecomastia in the prepubertal child are reviewed.

Estradiol↗

PubMedDate not supplied

Macrotestes associated with hyperprolactinemia.

Prolactin secreting pituitary adenomas are a rare finding in prepubertal children /1/. As in adults, their incidence is higher in girls than in boys; however, the macroadenomas are predominant in boys /20-16/. Two prepubertal boys who presented with short stature and linear growth deceleration were diagnosed to have prolactin secreting pituitary macroadenoma associated with growth hormone (GH) deficiency. They were treated with bromocryptine and exogenous recombinant hGH. They achieved a normal adult stature, full sexual maturation and tumor regression on the therapy. In addition, both boys developed macrotestes. Further evaluation ruled out other etiologies for macrotestes. We presume that the elevated prolactin caused local testicular growth factors to induce testicular cell division and/or hypertrophy resulting in an increased testicular volume.

Adolescent↗

PubMedDate not supplied

Testosterone therapy in Klinefelter's syndrome (a prolonged observation).

Clinical observations and pituitary gonadal hormone data was gathered in six patients with Klinefelter's Syndrome during a prolonged period of time. The secondary sex characteristics increased and the gynecomastia generally disappeared. Personality changes were also noted. In half of the patients, the abnormal level of luteinizing and follicular stimulating hormone remained elevated. An enlarged sella turcica was discovered in one patient. It is concluded that testosterone therapy is beneficial in all patients with Klinefelter's Syndrome.

Adolescent↗