Accumulation of 3H-homovanillic acid in rabbit brain and cerebrospinal fluid following intravenous 3H-L-dopa.
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Biomedical subjects
Publications and source records attributed to R H Roth.
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1. gamma-Hydroxybutyrate and its lactone precursor, gamma-butyrolactone, when administered in anaesthetic doses block the increase in the cerebral concentration of homovanillic acid normally observed after administration of chlorpromazine or haloperidol.2. Other hypnotics such as glutethimide, urethane, chloralose, chloral hydrate and thiopentone do not have this ability even when administered in anaesthetic doses.3. The ability of gamma-hydroxybutyrate to block the neuroleptic-induced increase in cerebral homovanillic acid is not due to a reduction in body temperature since a similar effect is observed in rats treated under conditions (32 degrees C) in which body temperature remains normal.4. Possible mechanisms for this action of gamma-hydroxybutyrate are discussed.
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