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R H Price

Publications and source records attributed to R H Price.

At least 37 records · Page 2Linked to original sources

Nitric oxide synthase neurons in rat brain express more NMDA receptor mRNA than non-NOS neurons.

Nitric oxide, the gaseous neuronal messenger, is produced by nitric oxide synthase (NOS) in a Ca2+ dependent manner. Indirect evidence suggests that glutamate, acting through the NMDA subtype of excitatory amino acid receptor, is the principle activator signal for NOS in the brain. To date there is a lack of direct evidence demonstrating NOS and NMDA receptors, or receptor message, in the same neurons. A double labeling technique was developed which uses NOS immunocytochemistry in combination with in situ hybridization for NMDA NR1 receptor mRNA. Quantitative analysis of the silver grain labeling resulting from the hybridization procedure revealed that the majority of NOS positive cells in the cerebral cortex, striatum and midbrain contained a significantly greater amount of NR1 receptor mRNA than non-NOS neurons in the same regions. The amount of NR1 mRNA per cell varies in the cortical and striatal NOS cells, with some cells showing no NR1 expression. These results indicate that NOS containing neurons do not reflect a single phenotype of mRNA expression and further suggest that some NOS cells may be activated by a non-NMDA receptor mechanism.

Amino Acid Oxidoreductases↗

Cerebellar excitatory and inhibitory amino acid receptors in multiple system atrophy.

We studied excitatory and inhibitory amino acid binding sites autoradiographically in control and multiple system atrophy (MSA) cerebella. Within the dentate nucleus (DN) of MSA specimens, we found a significant increase in the level of GABAA, benzodiazepine, and metabotropic binding sites compared with controls. In the granule cell layer, kainate, N-methyl-D-aspartate, and GABAA binding sites were all decreased significantly in MSA specimens compared with controls. In the molecular layer of MSA cerebellum, alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate binding sites were decreased significantly compared with controls. Cerebellar cortical binding site decreases are likely due to Purkinje and granule cell loss. The increase of binding site levels in DN of MSA specimens may represent receptor up-regulation reflecting loss of descending inhibitory Purkinje cell and ascending excitatory afferents to the DN.

Adult↗

Effective outpatient drug treatment organizations: program features and selection effects.

This research identifies program features that predict outpatient drug treatment outcomes. Treatment effectiveness is measured at the organizational level of analysis in a nationally representative sample of non-methadone outpatient drug misuse treatment organizations (N = 394). Multivariate analyses are conducted to identify program features at various stages of the client career that are related to client outcomes after controlling for client characteristics, organizational characteristics, and social area characteristics. Results indicate that effective non-methadone outpatient drug misuse treatment is related to a number of program features including adequate staff levels, quality assurance efforts, and client follow-up, as well as selection factors that reflect client problem severity.

Accreditation↗

Impact of a preventive job search intervention on the likelihood of depression among the unemployed.

Drawing on coping resources theory, we evaluate the impact of a job search intervention on depressive symptoms in a randomized field experiment at three follow-up periods covering two and one-half years. Baseline depressive symptoms, low social assertiveness, and financial hardship were identified as significant risk variables predicting depressive symptoms at follow-up. These variables then were used to identify high- and low-risk individuals in both experimental and control groups. Results indicated that the job search intervention had its primary impact on persons identified as being at higher risk for depression. Furthermore, the intervention had an impact on both the incidence and prevalence of more severe depressive symptoms among high-risk individuals.

Adaptation, Psychological↗

Excitatory and inhibitory amino acid binding sites in human dentate nucleus.

Autoradiography of excitatory and inhibitory amino acid binding sites in human dentate nuclei indicated virtually no binding to N-methyl-D-aspartate (NMDA) or gamma-aminobutyric acidB (GABAB) binding sites, and a low density of kainate binding sites. alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid, metabotropic-quisqualate, benzodiazepine, and gamma-aminobutyric acidA (GABAA) binding sites were present in moderate abundance. Our NMDA results differ from those found previously in rodents. GABAA receptors are probably the primary mediators of inhibitory neurotransmission and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid and metabotropic-quisqualate receptors are probably the primary mediators of excitatory neurotransmission within the human deep cerebellar nuclei.

Adult↗

From field experiments to program implementation: assessing the potential outcomes of an experimental intervention program for unemployed persons.

Demonstrated a procedure suggested by Bloom (1984) to provide estimates for the effects of an intervention on its actual participants compared to global effects on study participants in the intervention group, whether or not they showed up. Analyses were based on data collected in a field experiment that tested a preventive intervention for unemployed persons (Caplan, Vinokur, Price & van Ryn, 1989). Effect size estimates were two to three times larger for the actual participant group than for the entire experimental group on employment outcomes (e.g., earnings) and mental health (anxiety and depression). Further analyses produced results showing that compared to participants, the nonparticipants achieved significantly higher levels of reemployment at posttests and did not differ significantly from participants on all other outcomes. The results suggest that persons who most needed the intervention and benefited from it were drawn into it through self-selection processes.

Adolescent↗

Long-term follow-up and benefit-cost analysis of the Jobs Program: a preventive intervention for the unemployed.

Results are reported from a 2 1/2 year follow-up of respondents who participated in a randomized field experiment that included the Jobs Program, a preventive intervention for unemployed persons. The intervention was intended to prevent poor mental health and loss of motivation to seek reemployment and to promote high-quality reemployment. The results of the long-term follow-up were consistent with those found 1 and 4 months after intervention (Caplan, Vinokur, Price, & van Ryn, 1989). The results demonstrate the continued beneficial effects of the intervention on monthly earnings, level of employment, and episodes of employer and job changes. These findings are supported by a benefit-cost analysis, which demonstrates large net benefits of the intervention to the participants and to the federal and state government programs that supported the project.

Cost-Benefit Analysis↗

Isomorphism and external support in conflicting institutional environments: a study of drug abuse treatment units.

Using institutional theory, we developed predictions about organizational units that moved from an environment making consistent demands to one making conflicting demands. Many community mental health centers have diversified into drug abuse treatment. The units providing those services face conflicting demands from the traditional mental health sector and the new drug abuse treatment sector about which clients to serve, how to assess their problems, and who should provide treatment. We propose that in response to such demands these units will adopt apparently conflicting practices. Also, isomorphism with the traditional sector will be positively associated with external support from parent mental health centers and other actors in the mental health sector. Results generally support those predictions.

Community Mental Health Centers↗

Job seeking, reemployment, and mental health: a randomized field experiment in coping with job loss.

Cognitive theories of adherence to difficult courses of action and findings from previous survey research on coping with a major life event--job loss--were used to generate a preventive intervention, tested by a randomized field experiment. The aim was to prevent poor mental health and loss of motivation to seek reemployment among those who continued to be unemployed and to promote high-quality reemployment. Ss were 928 recently unemployed adults from southeastern Michigan, representing a broad range of demographic characteristics; they were randomly assigned to either the experimental or control condition. The experimental intervention included training in job seeking with a problem-solving process emphasizing inoculation against setbacks and positive social reinforcement. A pretest was administered, followed by posttests 1 and 4 months after the experiment. The experimental condition yielded higher quality reemployment in terms of earnings and job satisfaction, and higher motivation among those who continued to be unemployed.

Adult↗

The search for effective prevention programs: what we learned along the way.

Efforts by an American Psychological Association task force to identify model prevention programs for high-risk groups throughout the life span are summarized. Criteria for selection and program content are described, and implications for the construction, implementation, and evaluation of effective programs are discussed.

Community Mental Health Services↗

Social factors in psychopathology: stress, social support, and coping processes.

Our review has focused centrally on the etiologic significance of social factors in the development of psychopathology. Our implicit assumption has been that social factors in general, and stressors in particular, may play a causal role in the development of psychopathology. Yet the evidence is clear that the vast majority of people who are exposed to stressful life events or to chronic stress situations do not develop significant psychiatric impairments. For this reason, research interest over the past decade has shifted to factors like social support and coping strategies that may ameliorate the impact of stress. We have examined some of the important empirical results from recent studies of stress, support, and coping, and we have discussed ways in which these new understandings have informed long-standing attempts to explain group differences in emotional functioning. In each section of the review we have attempted not only to summarize existing results but also to provide some evaluation of the literature and suggestions for future research. It is important to recognize that the contributors to the work reviewed here do not all share a common research agenda. Some of them are primarily committed to unraveling the psychosocial determinants of a particular clinical disorder. Others are mainly concerned with the effects of a particular stressor. Still others are interested in the processes that link stress to health across a broad array of stress situations and health outcomes. In the face of these diverse interests, it is little wonder that our understanding of social factors in psychopathology is uneven. There is good reason to believe, however that these diverse strands of research are beginning to converge on a common conception of the stress process and on a common research design. The conception at present is only in rough form, but its outlines are nonetheless capable of description. At its center is the notion that stress exposure sets off a process of adaptation. It recognizes that this process unfolds over time, and it acknowledges that this process is modified by structural factors as well as by personal dispositions and vulnerabilities. There is growing recognition that the analysis of this process requires longitudinal methods. Also, it is becoming increasingly clear that experimental interventions are required to unravel the parts of this process that link stress and health. It is too early to know if this nascent convergence will lead to an integrative theory of adaptation, yet it is almost certain to promote methodological and conceptual rigor and facilitate replication and cumulation of findings.(ABSTRACT TRUNCATED AT 400 WORDS)

Adaptation, Psychological↗

Laser backpointer for use with a radiotherapy simulator.

A radiotherapy simulator with image intensification has been equipped with a laser backpointer which does not need to be removed during fluoroscopic examinations, provides negligible interference with the fluoroscopic image, and results in significant reductions in the time required for mark-up of patients. Accuracy of set-ups may be improved since rechecking of patient positioning has been simplified.

Lasers↗

Patient-treatment interactions among alcoholics.

The ratins of the different aspects of an alcoholism treatment program by patients before discharge revealed differences in views of the program that were related to differences in personality.

Adult↗