Search PubMed⌕ Search

Biomedical subjects

R H Messer

Publications and source records attributed to R H Messer.

33 records · Page 2Linked to original sources
PubMed1980

Vaginal absorption of povidone-iodine.

In 12 nonpregnant women, total iodine, protein-bound iodine, inorganic iodine, and thyroxine values were measured in serum before and 15, 30, 45 or 60 minutes after a two-minute vaginal disinfection with povidone-iodine (Betadine). Only 15 minutes after application, serum iodine levels were raised and remained significantly elevated 30, 45 and 60 minutes after disinfection. Serum concentrations of total iodine and inorganic iodine were increased up to fivefold to 15-fold, respectively; during the relative short period of observation, thyroxine levels were not altered. An overload of iodine can suppress thyroid hormonogenesis, and the fetal and neonatal thyroid glands are especially sensitive. In pregnant women, vaginitis should not be treated with povidone-iodine because of the possible development of iodine-induced goiter and hypothyroidism in the fetus and newborn. The risk is especially high when povidone-iodine is used repeatedly.

Absorption↗
PubMed1980

Antimicrobial effect of chlorhexidine on bacteria of groin, perineum and vagina.

The antimicrobial effects of two chlorhexidine preparations, Hibiclens and Hibitane Tincture, were evaluated in 154 obstetric patients. Both agents produced bacterial kills of over 99% on skin bacteria of groin and perineum ten and 30 minutes after their application. Five minutes after vaginal cleansing with Hibiclens more than 99% of bacteria originally present were destroyed. Even though both preparations proved to be potent bactericidal agents, Hibitane Tincture cannot be recommended as a perigenital antiseptic since it causes vulvar irritation due to its high isopropanol content. With Hibiclens application to groin and perineal skin no side effects were observed. In one of 51 patients treated vaginally with Hibiclens a rather strong burning sensation occurred, without any aftereffect. Hibiclens seems to be a promising antiseptic for obstetric and gynecologic patients.

Antisepsis↗
PubMed1979

Academic manpower for obstetrics and gynecology in the United States.

All 119 medical schools in the United States provided information for a study of academic manpower conducted by the Association of Professors of Gynecology and Obstetrics (APGO). The average number of full-time faculty members per medical school is 13.2, with 2 positions vacant per school. Subspecialists are concentrated in university medical school departments, which also have large residency programs. A perceived need for 46% more faculty over the next 5 years will probably aggravate the shortage.

Canada↗
PubMed1978

Breast cancer: potentially predisposing and protecting factors. Role of pregnancy, lactation, and endocrine status.

Risk factors of breast cancer have been correlated with the availability of estradiol and estrone. Mechanisms protecting from breast cancer are thought to be due to the mitotic rest of mammary epithelium (low deoxyribonucleic acid synthesis), as encountered during pregnancy and lactation, and to the actions of estriol and progesterone in opposing the "carcinogenic" estradiol and estrone.

Adult↗
PubMed1976

Maternal deaths in California from 1967 to 1971. A demonstration of the need for mortality review.

An evaluation of maternal mortality statistics in California from 1967-1971 has been performed. There has been a fall in the maternal mortality rate following the institution of a therapeutic abortion act. However, analysis of the data reveals that there was an increase in the deaths due to hemorrhage and sepsis. At this same time the maternal mortality study committee was discontinued. It is strongly felt that the data demonstrate the need for a continuing review of maternal deaths. A proposal is made to redesign the maternal mortality study committee so that it can fully meet the needs of the medical profession and the patient.

Abortion, Legal↗
PubMed1976

Maternal and fetal plasma cortisol levels at parturition.

Fetal adrenal function during pregnancy has a probable role in parturition. Ninety-five mothers and fetuses were evaluated to ascertain maternal or fetal plasma cortisol interrelationships under various clinical situations. When mode of delivery was evaluated, maternal cortisol levels showed no differences. However, the fetuses from vaginal delivery (mean, 43.7 mug/100 ml) had higher levels than those from cesarean section (mean, 34.7 mug/100 ml). Induction of labor showed a rise in maternal cortisol from preinduction levels (mean, 40.2 mug/100 ml) to delivery (mean, 49.6 mug/100 ml), probably reflecting the maternal stress of labor. The fetal cortisol level after induced labor (mean, 35.2 mug/ml) supporting the adrenal contribution to the initiation of labor. Gestational age of the fetus was significant in the fetal cortisol levels: 36 weeks or less (mean, 34.1 mug/100 ml); 37 weeks or more (mean, 44.5 mug/100 ml). This again supports the development of adrenal maturity. Fetal weight, postdatism, acute and chronic fetal distress, hypertensive disease in pregnancy, and race were evaluated without revealing any significant intergroup differences. Two anencephalic pregnancies were also studied.

Adrenal Glands↗
PubMed1974

Pregnancy anemias.

Explore the source record for details and available documents.

Administration, Oral↗
PubMedDate not supplied

The dosage of human chorionic gonadotropins influences the relationship between progesterone and cycle outcome during in vitro fertilization-embryo transfer.

OBJECTIVE: To determine if the dose of hCG affects the initial rise in progesterone seen in patients undergoing IVF-ET and therefore affects it usefulness as a predictor of cycle outcome. DESIGN: Comparison of the rise in progesterone with cycle outcomes for IVF patients receiving 5,000 or 10,000 mIU hCG to stimulate oocyte maturation. SETTING: University-based infertility program. Patients-One hundred six patients undergoing IVF-ET on a long protocol of down-regulation with GnRH, hMG stimulation, and hCG to stimulate oocyte maturation. Stimulation protocol varied only in dose of hCG [5,000 mIU (N = 72) vs. 10,000 mIU (N = 34)]. MAIN OUTCOME MEASURE(S): Rise in progesterone from 12 hours before to 12 hours after hCG administration and its relationship with cycle outcome. RESULTS: All 106 women exhibited a rise in progesterone following the administration of hCG. As seen in earlier studies, there appeared to be a relationship between minimal progesterone increases (<3-fold) and cycle failure in patients receiving 5,000 mIU (P < .02). However, using the criteria of the previous study, there appears to be no relationship between progesterone and cycle outcome in patients receiving 10,000 mIU (P = .30). Further, the higher dose of hCG appeared to induce greater increases in progesterone over the 24-hour period examined (P < .02). After readjustment of the critical value to 3.5-fold, there was an increased tendency toward cycle failure in women exhibiting a minimal progesterone increase. Unlike the relationship associated with 5,000 mIU hCG, though, the relationship between 10,000 mIU hCG and progesterone levels was not statistically different (P = .10). CONCLUSIONS: Increasing the dose of hCG used to stimulate oocyte maturity shifts the previously described relationship between progesterone and IVF-ET-cycle outcome. However, while it remains unclear if progesterone can be used as a predictor of outcome at the higher hCG dose, it appears clear that a relationship exists between minimal progesterone response to hCG and cycle failure.

Adult↗