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Biomedical subjects

R H Martin

Publications and source records attributed to R H Martin.

182 records · Page 11Linked to original sources
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The relationship between sperm chromosomal abnormalities and sperm morphology in humans.

It has been suggested that an assay for sperm morphology might prove useful as an initial screen in evaluating men at risk for an increased frequency of sperm chromosomal abnormalities. In this study, the technique for analysis of human sperm chromosomes after penetration of hamster eggs was employed to determine whether there is an association between the frequency of chromosomally and morphologically abnormal sperm. 30 healthy men of proven fertility were studied. The ages of the donors ranged from 22 to 55 years. The analysis was performed "blindly" so that the technician analysing the chromosome spreads had no knowledge of the age of the donors or of the individual frequencies of morphologically abnormal sperm. There was no significant relationship between the proportion of morphologically abnormal sperm and the proportion of chromosomally abnormal sperm when controlled for age. This was true for the total frequency of chromosomal abnormalities and also for numerical and structural chromosomal abnormalities. These results suggest that an assay of morphology is not a good indication of chromosomal normality in human sperm.

Adult↗
PubMedDate not supplied

The effect of myocardial preservation technique on operative mortality in complex valvular heart disease.

Between November, 1964 and January, 1983, 70 consecutive patients underwent primary repair of complex valvular heart disease, defined as repair or replacement of two or more cardiac values alone or with other concomitant cardiac procedures. A total of 163 operative procedures were performed on the 70 patients for an average of 2.33 procedures per patient. Review of these cases allowed the patients to be divided into two distinct groups, those receiving systemic hypothermia and cold potassium cardioplegic arrest of the heart (C) and those having other myocardial preservation techniques (NC). Thirty-three patients received C and are compared with 37 patients who received NC. The two patient groups were comparable when considered for preoperative cardiac index and functional classification though patients in C group were older. In the C group, 10 of 32 patients (31%) had associated coronary artery bypass grafting in contrast to 2 of 37 patients (5.4%) in the NC era. The mortality of the C group was 2 of 33 (6%) vs 14 of 37 (37.8%) in the NC group (P less than .001). Of the 14 deaths in the NC patients, 10 were due to low cardiac output syndrome. While other factors have undoubtedly played a role, improved myocardial preservation by the use of C and attention to coronary artery pathology may have contributed to the improved operative mortality in this group of patients with complex valvular heart disease.

Adult↗