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Biomedical subjects

R H Kaufman

Publications and source records attributed to R H Kaufman.

At least 127 records · Page 7Linked to original sources
PubMed1978

Design and preliminary observations of National Cooperative Diethylstilbestrol Adenosis (DESAD) Project.

The National Cooperative Diethylstilbestrol Adenosis (DESAD) Project has completed the major portion of its enrollment phase with the examination of more than 3000 daughters of women taking synthetic nonsteroidal estrogens (denoted DES) during pregnancies occurring from the early 1940s to the mid-1960s. The aims of the Project are to fill urgent needs for information on the prevalence and incidence of structural and epithelial abnormalities or neoplastic changes and their complications in these young women. Participants are grouped by mode of entry as identified by prenatal record review (40.1%), documented as DES-exposed but walking in (25.1%), or referred (22.8%) to the DESAD Project for examination, and not documented as exposed but having gynecologic abnormalities typical of those associated with DES exposure (12.0%). This study cohort, in part having paired controls, will be examined annually for at least 5 years. Details of the design and selected preliminary findings are reported.

Adolescent↗
PubMed1978

Association of cytomegalovirus (CMV) infection with cervical cancer: isolation of CMV from cell cultures derived from cervical biopsy.

Cytomegalovirus (CMV) was isolated from cell cultures derived from 2 of 10 cervical cancer biopsies from patients in an advanced stage of the disease. Five serial passages were necessary before extensive cytopathic changes characteristic of CMV infection appeared. All patients tested had complement-fixing antibodies to both isolates in higher titers than to the prototype AD169 strain. 6 of 8 patients tested also had herpesvirus type 2 antibodies.

Adult↗
PubMed1978

The lymphocyte transformation response of fetal hemolymphatic tissue to mitogens and antigens.

Lymphocyte transformation responses to three different mitogens (phytohemagglutinin (PHA), pokeweed mitogen (PWM), and concanavalin A (Con A)) as well as four antigens (streptolysin O (SLO), keyhole limpet hemocyanin (KLH), streptokinase-streptodornase (SKSD) and tuberculin purified protein derivative (PPD)) were studied ontogenetically in 30 human fetuses ranging in gestational age from 6-19 weeks. In most organs lymphocyte responsiveness to Con A in human fetuses seemingly develops in concert with responsiveness to PHA and PWM. One 19 week fetus had an apparent antigen specific response to SLO with stimulation of cord blood and bone marrow lymphocytes. The same fetus also had mitogen responsiveness in bone marrow.

Antigens↗
PubMed1978

Genital tract anomalies associated with in utero exposure to diethylstilbestrol.

The gross anatomic changes and the vaginal epithelial changes in 687 women exposed in utero to diethylstibestrol are described, as well as the findings in 66 of these women who agreed to undergo hysterosalpingography. Of 537 women in the study group whose time of in utero exposure to stilbestrol was known. 33% demonstrated gross anatomic changes of the cervix, whereas 44% of them were found on colposcopic examination to have vaginal epithelial changes. These changes occurred in a significantly higher percentage of women exposed in utero before the 20th week of gestation. Among the women included in the study on the basis of a review of their prenatal history, gross anatomic changes of the cervix seemed to be more common in those under the age of 19 years than in those older than 19 when they first entered the study. Gross abnormalities in the uterus were noted in 44 of the 66 women studied by hysterosalpingography. These changes consisted primarily of marked aberrations in the size and shape of the uterine cavity.

Adolescent↗
PubMed1978

Effect of maternal alcohol exposure on fetal ovarian lactate dehydrogenase.

Pregnant inbred mice strain Balb/c injected intraperitoneally with 100 mu1 of 70% ethanol for 7 consecutive days (9th through 16th day of gestation). One group of mice were also injected with diethylstibestrol (DES) dissolved in 70% ethanol. The lactate dehydrogenase (LDH) activity was measured 90 days postpartum in the crude extracts of ovarian tissues (obtained from mothers and offspring) as well as in testicular tissues of the male offspring. The data show that the electrophoretic pattern of LDH in these tissues does not change, but the ovarian LDH is inhibited by alcohol. The testicular LDH on the other hand is not affected by the alcohol treatment. Because of the effect of alcohol itself, the effect of DES could not be determined.

Animals↗
PubMed1977

The effect of marihuana (delta-9-tetrahydrocannabinol) on the secretion of luteinizing hormone in the ovariectomized rhesus monkey.

Despite the widespread use of marihuana by large numbers of young adults in the reproductive years, little is known about the effects of this drug on reproductive function. information on the effect of the drug on the woman is particularly meager. The rhesus monkey provides an excellent animal model from which to generalize to man. While the primary purpose of the project is to determine the effect of long-term administration on the cycling female monkey, the initial studies were carried out in the ovariectomized monkey with resulting elevated gonadotropin levels under conditions of short-term administration of the drug. Marihuana causes a reversible depression in luteinizing hormone levels in the ovariectomized female rhesus monkey.

Animals↗
PubMed1977

Upper genital tract changes associated with exposure in utero to diethylstilbestrol.

Hysterosalpingograms of 60 young women exposed in utero to diethystilbestrol were obtained. In 46 instances, documentation of this exposure was obtained from the mother's chart review or confirmed by the attending physician. In 14 instances, the patients' mothers were sure they had received stilbestrol, but documentation could not be specifically confirmed. Hysterosalpingograms of 23 women being investigated for infertility during the same period that the current study was conducted were also reviewed. In 40 women exposed to stilbestrol, changes in the uterus which differed significantly from those seen in the past in nonexposed individuals were noted. These changes consisted of a 'T-shaped appearance of the uterus,' constricting bands in the uterine cavity, a hypoplastic uterus, and less frequently, intrauterine polypoid defects, synechiae, and in one instance a unicornuate uterus. In 36 of the 40 women gross defects were also noted in the cervix. By comparison, in none of the control subjects were defects noted which could be considered comparable with those seen in the DES-exposed patient.

Adolescent↗
PubMed1976

Severe atypical endometrial changes and sequential contraceptive use.

Of eight young women, seven had a diagnosis of well-differentiated endometrial adenocarcinoma and one had atypical endometrial hyperplasia. The average age was 40.1 years, with 6.04 years of dimethisterone-ethinyl estradiol (Oracon) sequential contraceptive use. The patients were not typical of those in whom endometrial carcinoma develops. Although these cases do not prove that long-term administration of dimethisterone-ethinyl estradiol causes endometrial adenocarcinoma or atypia, they indicate that it may do so.

Adenocarcinoma↗