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Biomedical subjects

R H Gold

Publications and source records attributed to R H Gold.

At least 73 records · Page 4Linked to original sources

The other arthritides. Roentgenologic features of osteoarthritis, erosive osteoarthritis, ankylosing spondylitis, psoriatic arthritis, Reiter's disease, multicentric reticulohistiocytosis, and progressive systemic sclerosis.

Osteoarthritis may be divided into primary generalized and secondary forms. Primary generalized osteoarthritis is characterized by narrowing of cartilage, marginal osteophytes, and absence of erosions. The most common sites of involvement are the distal interphalangeal joints of the fingers and the first carpometacarpal joint. Secondary osteoarthritis also results in narrowing of cartilage in the absence of erosions, but in regions of mechanical stress. Erosive osteoarthritis affects predominantly the proximal and distal interphalangeal joints, and evolves into bony fusion in 12 to 15 per cent of cases, about the same percentage of interphalangeal bony fusion that occurs in psoriatic arthritis. Ankylosing spondylitis predominates in the axial skeleton where it eventually leads to fusion of the vertebrae and sacroiliac joints. Psoriatic arthritis combines many features of rheumatoid arthritis, in which synovial inflammation predominates, and ankylosing spondylitis, in which ligamentous inflammation predominates. The hands and feet are involved to an equal extent, and in 20 per cent of patients the disorder also involves the sacroiliac joints and spine. Reiter's disease, like psoriatic arthritis, differs from ankylosing spondylitis in its inconstant involvement of the spine and greater involvement of peripheral joints. Reiter's disease differs from psoriatic arthritis in its predominant involvement of the lower limbs, particularly the feet, with relative sparing of the hands and wrists. Multicentric reticulohistiocytosis is a rare disorder in which polyarthritis usually precedes the onset of nodular cutaneous eruptions, a fact that emphasizes the importance of early roentgenologic recognition. The interphalangeal joints are the predominant sites of involvement in the hands, but eventually all of the synovium lined joints become affected, with arthritis mutilans the end result in one third of cases. The erosions are strikingly symmetrical and well circumscribed, and accompanying osteoporosis is disproportionately mild. Progressive systemic sclerosis is characterized by atrophy and dystrophic calcifications in the soft tissues, ultimately leading to joint deformities and resorption of the terminal tufts of the phalanges. Resorption of bone occurs at other sites as well, and marginal erosions may develop in the metacarpophalangeal and interphalangeal joints of the hands.

Arthritis, Reactive↗

MR imaging of the knee. Part I. Traumatic disorders.

One hundred thirty patients with a diversity of knee joint injuries were evaluated with a high-resolution magnetic resonance (MR) imaging technique. The authors report the accuracy of this technique in the evaluation of 105 patients with suspected meniscal tears, 26 patients with suspected cruciate ligament tears, and eight patients with suspected patellar tendon injuries. Of those menisci rated as definitely or probably torn on MR imaging, 80% were found to be torn at subsequent arthroscopy. The predictive value of negative MR imaging results was 100%. MR imaging was 92% accurate in predicting the clinical outcome in patients with suspected meniscal tears who did not undergo surgery. MR permitted complete disruption of the patellar tendon to be differentiated from partial tears, ligamentous inflammation, and localized effusion of the infrapatellar bursa. Injuries to the anterior and posterior cruciate ligaments were identified on MR images, and the status of synthetic grafts of the anterior cruciate ligament was ascertained.

Humans↗

MR imaging of the knee. Part II. Chronic disorders.

Sixty patients with symptoms of chronic disease of the knee joint were evaluated with high-resolution, thin-section magnetic resonance (MR) imaging. MR imaging depicted a wide variety of knee joint abnormalities including osteochondritis dissecans, medullary infarcts, epiphyseal osteonecrosis, intraarticular osteochondral fragments, synovial cysts, joint effusions, intraarticular soft-tissue tumors, synovial disease, leukemic infiltration of bone marrow, Osgood-Schlatter disease, and nonossifying fibroma. In two cases MR imaging depicted bone infarcts not seen on both radionuclide bone scans and standard radiographs. The highly detailed depiction of the articular cartilage was of particular importance in predicting arthroscopic findings in cases of osteochondritis dissecans. In two cases, a soft-tissue mass (pigmented villonodular synovitis) and a large osteochondral fragment undetected at arthroscopy were accurately localized with MR imaging. The results indicate that MR imaging is capable of providing information that might otherwise require multiple, sometimes invasive diagnostic procedures.

Chronic Disease↗

Automated and hand-held breast US: effect on patient management.

Breast ultrasound (US) was performed, with either an automated or a hand-held unit or both, on 1,212 patients. Of 612 asymptomatic patients, 118 (19.3%) had solitary cysts; ten (1.6%), multiple cysts; and 29 (4.7%), benign masses; however, US depicted only one (0.2%) nonpalpable mammographically undetected carcinoma. In 513 patients with palpable masses (n = 396) and with mammographically detected masses (n = 117), US was useful in avoiding an unnecessary biopsy in 113 (22.0%), leading to aspiration of a cyst in 26 (5.1%), monitoring multiple cysts in 31 (6.0%), avoiding aspiration of a solid mass in 65 (12.7%), supporting biopsy of an equivocal solid mass in 91 (17.7%), and demonstrating a nonpalpable mammographically detected carcinoma in six (1.2%). In 224 patients with either palpable or mammographically visible masses who underwent both methods of US, the 4.5-MHz or 3.9-MHz automated unit depicted the abnormality in 119 (53.1%) and the 7.5-MHz hand-held unit, in 171 (76.3%). Of 18 cancers evaluated with both methods, all were detected with the hand-held unit and only 12 were seen with the automated unit.

Adolescent↗

Breast cancer detection: one versus two views.

Mammographic examinations of 169 patients with 172 biopsy-proved carcinomas, and of 194 healthy subjects, were interpreted independently and retrospectively by three experienced mammographers, initially as single-view oblique examinations and 6 months later as two-view oblique-cephalocaudal examinations. For the single-view examinations of the cancer patients, 67% of the cancers were correctly recommended for biopsy, additional views were requested for 23%, and a "negative" interpretation was made for 10%. For the single-view examinations of healthy subjects, biopsy was recommended for 7% and additional views were recommended for 32%. For the two-view examinations of women with cancer, 80% of the cancers were correctly recommended for biopsy, additional views were requested for 4%, and a "negative" interpretation was made for 16%. For two-view examinations of healthy subjects, biopsy was recommended for 7% and additional views were requested for only 5%. The authors conclude that single-view screening should not be performed, because it would lead to an excessive number of "call-back" examinations of healthy patients, producing additional cost and anxiety that would outweigh any theoretical benefit.

Adult↗

Mammographic dual-screen-dual-emulsion-film combination: visibility of simulated microcalcifications and effect on image contrast.

Three test objects simulating different mammographic problems were imaged with a new low-dose dual-screen-dual-emulsion-film combination and a standard screen film combination, with and without a moving grid, at 28 and 32 kVp, and with 0.3- and 0.5-mm focal spots. The new combination reduced exposure by 50%, but it failed to equal the other combination in the depiction of simulated microcalcifications, even when a different brand of film-processing chemicals was used. Compared with the standard screen-film combination exposed without a grid, the new combination exposed with a grid resulted in a superior image of dense parenchyma without an increase in dose. Furthermore, when the exposure time was decreased by 25% (rather than 50%), dense breasts were imaged with greater penetration by the new combination. A clinical trial of the new combination in 200 patients showed prominent quantum mottle and reduced contrast in regions of dense parenchyma. In addition, the skin and subcutaneous tissue were often poorly depicted with both standard and high-intensity illumination.

Breast Neoplasms↗

Elbow joint: normal anatomy on MR images.

The normal anatomy of the elbow joint in axial, sagittal, and coronal planes was evaluated by comparing 30 magnetic resonance (MR) images of eight healthy volunteers with microtomed cryosections prepared from six cadaver elbows. MR images provided depiction of muscles and tendons, bone marrow, articular cartilage, and neurovascular structures. Cross-referencing of MR images from one plane to another was useful in the evaluation of complicated, obliquely oriented muscle bundles and other soft tissues.

Cadaver↗

Evaluation of radiation dose, focal spot, and automatic exposure of newer film-screen mammography units.

Fifteen recently introduced mammographic units representing eight different models and manufacturers were evaluated to see whether the equipment performance equaled claims made by the manufacturers. Focal-spot size was measured by pinhole and slit methods. Eight automatic exposure control systems on five models were tested by measuring the optical density produced by imaging at 28 and 30 kVp, with and without a grid and with test objects of varying thicknesses of BR12 epoxy material. Comparable mean glandular dose for a 4-cm-thick BR12 test object was measured for 13 of the units under manual or automatic exposures. Nominal focal-spot size was larger than stated for six of the 15 large focal spots and for seven of the 12 microfocal spots. Comparable doses under automatic exposure control varied more than 100% between units from different manufacturers, while the doses of units from the same manufacturer varied less than 20%. Automatic exposure control systems were operational in eight of the 15 units, but four of these eight were found to be out of calibration. There are considerable performance variations that need to be evaluated before acceptance and use of new mammographic equipment.

Breast↗

Survey of mammography practices.

Of the 319 radiologists who responded to a survey concerning mammography practices, 50% were employed in a private hospital and 26% in a private office. Film-screen mammography was used most often (54%) followed by xeromammography (30%) and a combination of film-screen and xeromammography (16%). Of the respondents, 62% had changed their method of performing mammography in the last 10 years. Of these, 50% had switched from xeromammography to film-screen, 23% from direct film to film-screen, 15% from direct film to xeromammography, and 6% from film-screen to xeromammography. Mammographic equipment had been purchased by 71% of respondents after 1983. Most respondents (71%) monitored mammography equipment doses, usually at 6- to 12-month intervals. Manual breast examinations were done at the time of mammography at 42% of the facilities, and breast self-examination was taught at 32%. For screening, 87.4% used a two-view examination, 92% required the name of a referring physician to whom the report could be sent, 28% accepted self-referred patients, and only 12% charged a reduced fee for screening. Breast sonography was performed by 53% (93% hand-held vs 7% automated), but none used sonography for screening. Only one respondent reported using thermography; three used light scanning. A need for postgraduate mammography courses for radiologists was indicated by 81%, while 69% recommended technologist courses and 64% recommended 1-week fellowships for radiologists.

Breast Neoplasms↗

Mammography screening: successes and problems in implementing widespread use in the United States.

Deterrents to the use of screening mammography include perceived risks of radiation, perceived "unnecessary" biopsies and overdiagnosis, and high cost. In addition, physicians and patients have attitudinal barriers that do not reflect objective realities. Professional and public education efforts are needed to enable women and their physicians to develop a more sophisticated understanding of the usefulness of screening mammography and the role played by the radiologist. As part of their efforts to increase the implementation of screening mammography, the American College of Radiology has developed a Mammography Accreditation Program for radiological facilities and has produced a free Mammography Resource Kit for radiologists, while the American Cancer Society has undertaken the support of local and national campaigns to establish screening programs at reduced cost. Both organizations continue to strive in partnership to increase the acceptance of screening throughout the United States.

Allied Health Personnel↗

Ischemic necrosis of the femoral head. Correlation of magnetic resonance imaging and histologic sections.

Magnetic resonance (MR) images were correlated with matched histologic sections of a resected ischemic necrotic femoral head and neck. Preoperative radiographs had revealed Stage 3 ischemic necrosis. Preoperative MR images disclosed foci of abnormally low signal intensity alternating with normal-appearing foci of high signal intensity. Surgical resection of the femoral head and neck was followed by MR imaging and pathologic sectioning, fixation, and staining, enabling the individual sections to be compared with the postoperative MR slices. A subchondral focus of diminished signal intensity was shown to represent saponified fat and consisted of a transudate of proteinaceous material with probable calcifications. The subjacent region of normal, high signal intensity represented "mummified" fat. The next lower stratum of diminished signal intensity was composed of fibrous and vascular tissues and histiocytic infiltrates that had extensively or completely replaced the fatty marrow.

Adult↗

Magnetic resonance imaging in the early diagnosis of ischemic necrosis of the femoral head. Preliminary results.

Magnetic resonance imaging (MRI) was performed on the hips of 25 patients with suspected ischemic necrosis of the femoral head. Twenty-six femoral heads manifested MRI changes of ischemic necrosis: diminished bone marrow signal in a ringlike, focal, or diffuse pattern. Plain radiographs were normal in 13 of 26 MRI-positive hips; six were asymptomatic. MRI was more effective in detecting early cases than conventional 99mTc-diphosphonate or 99mTc-sulfur colloid (SC) bone scanning. There were no false-negative MRI examinations, but diphosphonate scans were negative in nine hips with normal radiography and abnormal MRI. Sulfur colloid scans were normal in only two hips with positive MRI, but SC scan results were often equivocal because isotope deficits were bilaterally symmetric. The results of this preliminary investigation imply that MRI has extraordinary sensitivity for the detection of early ischemic necrosis. Unlike radionuclide scanning, MRI shows the exact location and extent of femoral head necrosis. Because MRI is expensive, it should be used in a cost-effective manner. Therefore, MRI is best suited for the diagnosis of early cases where less expensive tests are negative or equivocal and as a precursor to more costly interventional procedures, such as core biopsy study or decompression.

Adult↗