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Biomedical subjects

R H Fox

Publications and source records attributed to R H Fox.

At least 19 recordsLinked to original sources
PubMed1990

Reduction of post-traumatic swelling and compartment pressure by impulse compression of the foot.

Following the discovery of a powerful venous pump in the foot that is activated by weight-bearing independently of muscular action, a pneumatic impulse device was developed to actuate this pump artificially. In a multicentre international trial the device was shown to reduce post-traumatic and postoperative swelling; pain also was alleviated. Evidence is also presented that dangerously high compartment pressures may be reduced to acceptable levels and fasciotomy avoided. We present an explanation of the clinical effects of activation of the venous footpump, based on recent improved understanding of the physiology of the microcirculation. The hyperaemic response that follows the liberation of endothelial-derived relaxing factor (EDRF) by sudden changes of pressure after weight-bearing or impulse compression is particularly important.

Adolescent↗
PubMed1980

Search of the homicide scene.

The initial protection of the homicide scene by the first investigators to arrive plays a vital part in allowing the accumulation of evidence that can lead to conviction. A given set of circumstances which comprises a given scene is never left wholly unchanged by the commission of a crime and/or the passage of the perpetrator to or from that scene.

Adult↗
PubMed1977

Accidental hypothermia and impaired temperature homoeostasis in the elderly.

A longitudinal study of the age-related decline in thermoregulatory capacity was made in 47 elderly people to try to identify those at risk from spontaneous hypothermia. During the winters of 1971-2 and 1975-6 environmental and body temperature profiles were obtained in the home, and thermoregulatory function was investigated by cooling and warming tests. Environmental temperature and socioeconomic conditions had not changed but the body core-shell temperature gradients were smaller in 1976, indicating progressive thermoregulatory impairment. People at risk of developing hypothermia also seem to have low resting peripheral blood flows, a nonconstrictor pattern of vasomotor response to cold, and a higher incidence of orthostatic hypotension.

Aged↗
PubMed1977

Voluntary isometric muscle strength of patients undergoing rehabilitation following fractures of the lower limb.

Isometric muscle strength was measured in 32 servicemen recovering from fractures of the lower limb. At the time when patients were admitted for rehabilitation there were marked reductions of strength in the injured limb of muscles acting at the hip, knee and ankle joints. Marked improvement of strength occurred during rehabilitation, but there were still significant differences between the limbs at the time of discharge from the rehabilitation unit.

Ankle Joint↗
PubMed1976

Differentiation of Micrococcus luteus and Micrococcus varians on the basis of catalase isoenzymes.

Crude extracts prepared from four Micrococcus varians strains, 11 M. luteus strains and four laboratory isolates subsequently classified with M. luteus were assayed for catalase activity following electrophoresis on polyacrylamide gels. The enzyme patterns produced from the M. varians strains exhibited three catalase isoenzymes which were distinguished into two types of patterns depending upon the location of the major band. The extracts from all the M. luteus strains produced the same pattern, composed of two catalase isoenzymes of similar electrophoretic mobility. For both species the isoenzyme patterns agreed with the differentiation based on biochemical properties. The catalase activity activity staining method was shown to be a restricted yet reliable assay in the intrageneric but not intraspecies differentiation of yellow-pigmented micrococci.

Catalase↗
PubMed1975

Measurement of deep body temperature from the urine.

1. The relation between urine and rectal temperatures has been studied under a variety of conditions by using the Uritemp bottle, which measures deep body temperature from the urine. 2. This device gives a reliable measurement of deep body temperature and has advantages over both rectal and oral techniques for many clinical applications. 3. The development of a new and more reliable device, the Uritemp meter, is described. Urine is voided through a specially designed and disposable unit, equipped with either a standard mercury-in-glass thermometer or any one of a range of commercially available electronic thermometers. Provision is made to collect a urine sample simultaneously if required.

Adult↗
PubMed1975

Enzyme electrophoretograms in the analysis of taxon relatedness of Micrococcus cryophilus, Branhamella catarrhalis and atypical Neisserias.

Extracts were prepared from Micrococcus cryophilus, several strains of Branhamella catarrhalis and Neisseria spp. Esterases, NADP-dependent isocitrate dehydrogenase and malate dehydrogenase activities were assayed after electrophoresis of extracts of polyacrylamide gels. Except for Neisseria perflava and N. sicca which resolved activity bands for the acetate-esterase only, the remaining bacteria exhibited species-specific esterase patterns also for the propionate and butyrate substrates. The multiple esterase patterns from B. catarrhalis ATCC25238 were qualitatively and quantitatively different from those of B. catarrhalis ATCC23246. This finding and other evidence supports a taxonomic shift of the latter to a species level of that genus. The atypical neisserias N. caviae and N. ovis appeared to exhibit an intrageneric specificity in their esterase patterns with those from B. catarrhalis but not to the other Neisseria spp. tested. The malate dehydrogenase patterns from the atypical neisserias and B. catarrhalis ATCC23246 were qualitatively similar; however, the patterns of isocitrate dehydrogenase activity were variable for these species. Micrococcus cryophilus was distinct in its esterase and dehydrogenase bands, strongly suggesting its taxon unrelatedness to the genus Branhammella or the atypical neisserias. Of the enzymes assayed, esterase proved to be the most reliable for taxonomic identifications.

Acetates↗
PubMed1975

Thermoregulation during marathon running in cool, moderate, and hot environments.

A well-trained subject, age 38, ran continously for periods ranging from 60 to 165 min on a motor-driven treadmill at 255.7 m/min while confronted with an airflow equivalent to running speed in cool, moderate, and hot environments. After a period of intensive heat acclimatization, treadmill runs were repeated in the moderate and hot conditions. Measurements were also obtained outdoors in a competitive marathon race. Sweat rate (SR) and mean skin temperature (Ts) were linearly related to Tdb. Acclimatization did not alter VO2max or metabolic rate during the treadmill runs, but heart rat (HR),rectal temperature (Tre), and Ts were lower, SR was higher, and maximal run duration longer in the hot environment, postacclimatization. Maximum runs in the hot environment were terminated by a spiralling increase in Tre to hyperthermic levels, due largely to a marked reduction in cutaneous blood flow, probably reflecting cardiovascular overload from the combined muscular and thermoregulatory blood flow demands, coupled with the effects of progressive dehydration. Utilizing partitional calorimetry and the subject's metabolic heat production, two examples of limiting environmental conditions for his marathon running speed were given.

Acclimatization↗