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Biomedical subjects

R H Chaney

Publications and source records attributed to R H Chaney.

26 records · Page 2Linked to original sources

Predictability of blood pressure response to isometric stress.

Isometric exercise causes transient systemic hypertension, but with individual differences. An attempt was made to delineate predictors of those differences by analyzing the blood pressure (BP) response in terms of variables readily measured in clinical practice. For each of 270 office patients, we determined blood pressure, heart rate (HR), electrocardiographic findings, and symptoms in response to maximal isometric and maximal dynamic exercise. For systolic BP response as the predicted measure, 4 predictor variables in combination, including age, sex, resting systolic BP, and maximal treadmill systolic BP, yielded 70% predictability. For diastolic BP, 5 predictors in combination, including handgrip strength, resting diastolic BP, treadmill HR, systolic BP, and diastolic BP, allowed 66% prediction. Not predictive of either were resting HR, abnormality of treadmill test, presence of heart disease, and certain other medical diagnoses.

Adult↗

Comparison of cardiovascular risk in maximal isometric and dynamic exercise.

With the hypothesis that isometric exercise testing offers important clinical information yet is neglected because of overemphasis on its risk, we compared it with dynamic testing for variables indicative of myocardial ischemia. In a medical office, 287 patients were each subjected once to both a one-minute maximal handgrip stress test and maximal treadmill test while monitored noninvasively for cardiovascular responses. Systolic blood pressures usually increased more with the treadmill test, diastolic more with the handgrip. The treadmill tests caused greater mean heart rate and rate-pressure products, as well as more ST segment displacements, arrhythmias, and symptoms and signs. However, there were some unpredictable individual differences in the isometric blood pressure responses. Isometric testing is easy and useful and, if properly monitored, causes less risk to the patient than dynamic testing.

Adult↗

Comparison of blood pressure and rate-pressure product responses in maximal dynamic and isometric exercise.

The relationship between hemodynamic responses to maximal dynamic and isometric exercise have not been clearly established. We monitored heart rate (HR), systolic and diastolic blood pressure (SBP, DBP), electrocardiogram (ECG), as well as symptoms and signs, during both maximal treadmill test (GXT) and one-minute maximal handgrip dynamometry (HG) in the same individuals. Subjects were 164 adult male office patients, ages 20-79 years, who were not on medication. There was a wide range of responses in HR, SBP, DBP, and heart rate-systolic blood pressure product (MTTI), but with significant differences in mean values between GXT and HG as follows. SBP absolute value and percent increase over resting level were higher on GXT than on HG, DBP was higher on HG than GXT. HR was greater on GXT than on HG, MTTI was greater on GXT than on HG, both for mean absolute value and percent increase over resting level. Normal GXT related to lower SBP response on HG, abnormal GXT to higher. Normal vs abnormal GXT did not correlate significantly with MTTI. SBP on maximal HG was greater than it was for low levels of GXT, less than for high levels of GXT. DBP increase was greater for maximal HG than for any level of GXT. BP response is critical in monitoring HG, as HR is for GXT. Both GXT and HG are useful tests, without undue risk if contra-indications are observed and patients are properly monitored. There are notable HR, BP and MTTI differences in the two tests, which can only be determined by monitoring each individual.

Adult↗

Comparison of respiratory mortality in the profoundly mentally retarded and in the less retarded.

Autopsy records of 600 profoundly retarded and 405 less retarded were examined for a thirty-one-year period at Pacific State Hospital. The profoundly retarded were found to have more respiratory infections at autopsy, and more deaths of such infections. Profound retardation was a particularly outstanding risk when in combination with epilepsy, inability to ambulate, and developmental cranial anomalies. Non-infectious respiratory morbidity and mortality are more common in the less retarded, apparently because of their living longer to develop these complications.

Adolescent↗