Biomedical subjects

R H C Bisschops

Publications and source records attributed to R H C Bisschops.

3 recordsLinked to original sources

PubMed2004

A fetal circle of Willis is associated with a decreased deep white matter lesion load.

OBJECTIVE: To investigate the relationship between morphologic differences in the circle of Willis and the presence and location of white matter lesions (WMLs). METHODS: Two hundred forty-three consecutive patients with clinical manifestations of atherosclerotic disease underwent MRI of the brain and MR angiography of the circle of Willis. RESULTS: Subjects with a fetal configuration of the circle of Willis demonstrated a decreased load of small (p < 0.01) and medium (p < 0.01) deep WMLs compared with subjects with a nonfetal configuration of the posterior part of the circle of Willis. CONCLUSION: A fetal configuration of the posterior part of the circle of Willis may be an important protecting determinant in the etiology of white matter lesions.

Aged↗

PubMed2004

High total cerebral blood flow is associated with a decrease of white matter lesions.

BACKGROUND: Low cerebral blood flow (CBF) has been associated with the presence of white matter lesions (WMLs). However, the power of these studies was insufficient (n=20-35) to determine whether flow is associated with WMLs. PURPOSE: The aim of this study was to investigate whether total cerebral blood flow (tCBF) is associated with the severity of white matter lesions (WMLs) in a large patient sample. SUBJECTS AND METHODS: 228 patients with clinical symptoms of cardiovascular disease had MRI of the brain, consisting of a T2-w FLAIR and a 2D phase-contrast flow measurement of the internal carotid arteries and the basilar artery. WMLs were graded according to prevalence and size of deep and periventricular WMLs. To determine the relation between tCBF and WMLs we used linear and logistic regression analysis adjusted for age, gender, intima media thickness and hypertension. RESULTS: We observed an inverse association between the tCBF and the total number of WMLs adjusted for age, gender, intima media thickness and hypertension [B=-1, 0 WML 95% CI (-2.0 to 0.0, p=0.045) per 100 mL increase in tCBF]. The adjusted odds ratio for the presence of severe WMLs in patients with high tCBF (> 675 mL/min) was 0.5 (95% CI 0.2-1.0) compared with patients with normal tCBF. CONCLUSION: In this study we found that high tCBF is associated with a decrease in presence and severity of WMLs.

Adult↗

PubMed2003

Collateral flow and ischemic brain lesions in patients with unilateral carotid artery occlusion.

OBJECTIVE: To investigate the association between ischemic brain lesions and intracranial collateral blood flow in patients with unilateral occlusion of the internal carotid artery (ICA). METHODS: Sixty-eight consecutive patients were included. Ischemic lesions on MRI were identified on hard copies, and volume measurements of the lesions were performed on an MR workstation. Intracranial collateral pathways were studied with MR angiography, digital subtraction angiography, and transcranial Doppler sonography. RESULTS: The presence of collateral flow via the anterior communicating artery (ACoA) was associated with a reduction in prevalence (p = 0.01) and volume (p = 0.008) of internal border zone infarcts in the hemisphere ipsilateral to the occluded ICA. Absence of collateral blood flow via the circle of Willis was associated with an increase in prevalence (p = 0.007) and volume (p = 0.005) of internal border zone infarcts. No association between any collateral flow pattern in the circle of Willis and periventricular lesions or lacunar, territorial, or external border zone infarcts was found. No association between collateral flow via the ophthalmic artery or leptomeningeal vessels with any type of ischemic lesion was found. CONCLUSION: Collateral flow via the ACoA is associated with a reduction of the prevalence and volume of internal border zone lesions but not with any other type of ischemic lesion. The presence of a functional posterior communicating artery or secondary collateral pathways is not associated with the prevalence of any type of ischemic lesion.

Adult↗