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Biomedical subjects

R Guillet

Publications and source records attributed to R Guillet.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Aging-related changes in brain metabolism are altered by early developmental exposure to diazepam.

To study the long-term effects of prenatal diazepam (DZ) exposure, 31P NMR (nuclear magnetic resonance) spectra and levels of thiobarbituric acid (TBA)-reactive material were measured in the brains of rats from 3 to 26 months of age. In control rats, there were aging-related increases in levels of TBA-reactive material, decreases in intracellular pH (pHi) and alterations in phosphocreatine (PCr) utilization. Prenatal (late gestational) DZ exposure induced lasting, dose-related and age-related alterations in levels of TBA-reactive material and pHi. The results indicate that the prenatal chemical environment can influence cellular metabolism throughout the lifetime of the organism, and that the process of aging can in turn interact with the consequences of prenatal drug exposure.

Aging↗
PubMedDate not supplied

[Perforation of the cervical esophagus during tracheal intubation. Apropos of a personal case].

On the occasion of a personal case of perforation of the cervical oesophagus by laborious tracheal intubation which had necessitated the use of a rigid stilet, we found seven similar cases in the literature since 1971 which can be added to the 16 collected by DUBOST in 1971. We analyse the etiological circumstances, the clinical picture the course and action taken in these eight cases. From this we draw practical conclusions which are imperative during anesthesia.

Cholecystectomy↗