Growth hormone and diabetes in man. Old concepts--new implications.
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Acromegaly↗
Biomedical subjects
R Guillemin
Publications and source records attributed to R Guillemin.
Direct sequence determination of ovine luteinizing hormone releasing factor by mass spectrometry.
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Acetone↗
[Solid-phase total synthesis of a tetradecapeptide having the chemical and biological properties of somatostatine].
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Methods↗
Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone.
A peptide has been isolated from ovine hypothalamus which, at 1 x 10(-9)M, inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats. Its structure is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH The synthetic replicate is biologically active.
Amino Acid Sequence↗
Chemistry of hypothalamic releasing factors.
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Chemical Phenomena↗
Synthetic luteinizing hormone-releasing factor analogs. Series of short-chain amide LRF homologs converging to the amino terminus.
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Amides↗
Primary structure of somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone.
Somatostatin, a peptide isolated from ovine hypothalamic tissue that inhibits the release of radioimmunoassayable growth hormone in vitro from rat or human pituitary cells or in vivo in rats, has the primary structure [Formula: see text]. The structure was established by submitting the carboxymethylated peptide, the carboxymethylated tryptic digest, and the chymotryptic digest of the peptide to Edman degradation. Degradation products were analyzed by amino-acid analysis, as well as in some cases by determination of N-termini by dansylation or by determination of phenylthiohydantoins by mass spectrometry.
Amino Acid Sequence↗
Hypothalamic control of adenohypophysial secretions.
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Adrenocorticotropic Hormone↗
Concomitant release of FSH and LH induced by native and synthetic LRF.
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Animals↗
Lack of effect of native or synthetic LRF on secretion of prolactin in vitro.
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Animals↗
Characteristics of the pituitary binding sites for thyrotropin releasing factor.
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Animals↗
TRF and thyroid hormones on prolactin secretion by rat anterior pituitary cells in vitro.
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Animals↗
Gonadotropin responses to synthetic LRF: dose-response relationship in men.
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Adult↗
Inhibition of growth hormone release in humans by somatostatin.
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Adult↗
Effect of perphenazine on the secretion of prolactin in vivo and in vitro.
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Animals↗
An in vivo corticotropin-releasing factor (CRF) assay based on plasma levels of radioimmunoassayable ACTH.
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Adrenocorticotropic Hormone↗
Chemistry of the hypothalamic releasing factors--studies on structure-function relationships.
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Animals↗
Chemistry of the hypothalamic releasing factors. Studies on structure-function relationships in TRF and LRF.
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Animals↗