Search PubMed⌕ Search

Biomedical subjects

R Guerra

Publications and source records attributed to R Guerra.

At least 91 records · Page 5Linked to original sources
PubMed1985

Inhibitory effect of the flavonoid silymarin on the erythrocyte hemolysis induced by phenylhydrazine.

The flavonoid silymarin, which is used as a therapeutical agent in the treatment of liver diseases, can inhibit the hemolysis and lipid peroxidation induced by phenylhydrazine on erythrocytes obtained from rats treated with the flavonoid. This effect is ascribed to the antioxidant properties as a free radical scavenger exhibited by the flavonoid. Silymarin failed to inhibit the glutathione depletion induced by phenylhydrazine on erythrocytes. It is proposed that the flavonoid acts at the membrane level of the cell avoiding the lipid peroxidative and fluidizing effect of phenylhydrazine.

Animals↗
PubMed1981

Penetration of parenteral cefuroxime into the human aqueous humor.

Concentrations of (6R-[6 alpha,7 beta(Z)])-3-([(amino-carbonyl)oxy]metyl)-7-([2-furanyl(methoxyimino)-acethyl] amino)-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carbonic acid (cefuroxime) were studied in blood and aqueous humor of 25 patients after various parenteral doses. lows: 1 h after a single 2 g i.v. dose; 1 h after the second of 2 1.v. doses of 2 g at an interval of 3 h; 6 h after a 2-g i.v. dose; 1 h after a 1.5-g i.m. dose; 1 h after the second of 2 i.m. doses of 1.5 g at an interval of 3 h. The highest levels of cefuroxime in blood (18.1 +/- 2.79 micrograms/ml) and in aqueous humor (4.1 +/- 1.98 micrograms/ml) were reached 1 h after the second administration of a 1.5-g i.m. dose.

Aged↗
PubMed1981

[Digoxin-quinidine and digoxin-amiodarone interactions. Effects on blood levels of the cardioactive glycoside].

With ever increasing frequency potentially dangerous interactions are reported between Cardiac Glycosides and other drugs, particularly the antiarrhythmic one. The AA, carried out this work with the intent of studying the possible modifications produced by Q and A on the SDL. First of all the AA. retrospectively studied the SDL of patients treated with the associations Q-D and A-D and this SDL was compared with the SDL of patients treated with D alone. Then 10 subjects treated sequentially, at first with D alone and after with the Q-D (5 p.) and A-D (5 p.) association, were studied. The results obtained confirm the data of other AA. regarding the Q-D interaction; in fact, in the presence of this antiarrhythmic drug, the SDL increase significantly following the concomitant pharmacological effects of the Cardiac Glycosides. The SDL on the contrary seem not be influenced by the A-D association. The AA. then reviewed the literature about the mechanism of the Q-D interaction. The majority of the AA. agree outlining a reduction of the Volume of Distribution and of D Clearance, in consequence of the concomitant administration of Q, which would explain the high SDL obtained. In conclusion the AA. suggest, when the Q-D association is mandatory, a 50% reduction of the D maintenance dose and to check periodically the ECG and SDL.

Adult↗