Biomedical subjects

R Greenberg

Publications and source records attributed to R Greenberg.

At least 199 records · Page 11Linked to original sources

PubMed1976

Editorial: Viral surveillance in Louisiana-1975.

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Adolescent↗

PubMed1975

Indomethacin potentiation of the response of the rabbit portal vein to electrical stimulation: effect of stimulus frequency and train length.

The response of the rabbit isolated portal vein to electrical stimulation was potentiated by indomethacin (10 mug/ml). This potentiation was dependent upon frequency but independent of the number of pulses in a train. It is concluded that these results add further support for the idea that indomethacin increases the release of newly synthesized noradrenaline as a result of inhibition of prostaglanding synthesis.

Animals↗

PubMed1975

Comparative pharmacological studies on butriptyline and some related standard tricyclic antidepressants.

Butriptyline was compared with imipramine and other tricyclic antidepressants for its ability to modify: (a) contractions of the cat nictitating membrane induced by noradrenaline (NA) and 5-hydroxytryptamine (5-HT), (b) the adrenergic neuron blocking action of guanethidine in the guinea pig vas deferns, (c) the rabbit's electroencephalogram (EEG) and physostigmine arousal, and (d) the sleep pattern of the rat. Imipramine and amitriptyline potentiated the NA and 5-HT effects on the nictitating membrane and antagonized the inhibitory actions of guanethidine in the guinea pig vas deferens, whereas iprindole and butriptyline were ineffective. These results are consistent with the ability of these drugs to block the neuronal uptake of catecholamines. Butriptyline was a potent blocker of the arousal reaction induced by physostigmine. Butriptyline (20--30 mg/kg) and amitriptyline (10--20 mg/kg) reduced rapid eye movement sleep with a conmitant increase in non-rapid eye movement sleep. This may be a reflection of the dual activity observed in the clinic with these compounds, namely, antidepressant and antianxiety effects.

Amitriptyline↗

PubMed1975

Some pharmacological effects of prodolic acid, a new anti-inflammatory compound, indicative of inhibition of prostaglandin synthesis.

Prodolic acid, a new non-steroidal anti-inflammatory compound, inhibited bradykinin-induced bronchoconstriction but did not affect histamine-induced bronchoconstriction in the guinea pig. Prodolic acid potentiated the responses of the isolated rabbit vas deferens and portal vein to electrical stimulation without altering the response to noradrenaline. The potentiating effects of prodolic acid on the vas deferens were reversible but the potentiating effects in the portal vein were frequency-dependent. It is concluded that these effects of prodolic acid are probably related to its ability to inhibit prostaglandin biosynthesis.

Airway Resistance↗

PubMed1975

The bronchodilator acitivity of an 11-deoxyprostaglandin (AY 23 578).

The bronchodilator activity of AY-23 578 was studied in vivo and in vitro techniques. In the conscious guinea pig, aerosols of AY-23 578, prostaglandin (PGE2) E2, and isoproterenol afforded significant protection against histamine-induced convulsions. In the anesthetized guinea pig, where changes in tracheal pressure were taken as an index of bronchoconstriction, AY-23 578, PGE2, and isoproterenol were equipotent in inhibiting the bronchoconstriction induced by histamine. AY-23 578, PGE2, and isoproterenol reduced or prevented neostigmine-, prostaglandin F2alpha- or carbachol-induced increases in pulmonary resistance, and decreases in dynamic compliance in the anesthetized cat. The activities of the former two compounds were qualitatively similar but less potent than isoproterenol. In both the guinea pig and the cat, the aerosol administration of effective bronchodilator doses of AY-23 578 did not exhibit any significant cardiovascular effects. Both AY-23 578 and PGE2 caused relaxation of the isolated guinea pig tracheal strip; PGE2 was about six times more potent than AY-23 578. It is concluded that AY-23 578 is an effective bronchodilator in both the guinea pig and cat.

Aerosols↗

PubMed1975

Clinical measurement in psychoanalysis: an approach.

Measurement of the complex phenomena in psychoanalysis is approached by defining interrelated elements in the analytic situation and specifying the range of their variation in scales which can be both generalized and made specific for an individual patient. Using this approach in transcripts of psychoanalytic sessions, we rate painful emotion, impairment of defensive maneuvers, and activation of threatening conflictual fantasies. This preliminary study involved rating of tape-recorded sessions by psychoanalytically oriented judges. Quantitative estimates appeared to relate in many ways to qualitative fluctuations in the patient's state. Such an approach may be helpful in developing more effective clinical theory about emotions, defensive processes, and transference fantasies.

Adult↗

PubMed1974

The effects of indomethacin and eicosa-5,8,11,14-tetraynoic acid on the response of the rabbit portal vein to electrical stimulation.

1 The effects of indomethacin and eicosa-5,8,11,14-tetraynoic acid (ETYA) on the contractile response of the transmurally stimulated rabbit portal vein were studied in vitro.2 When the veins were stimulated for 240 pulses at 1 and 2 Hz, the responses were potentiated by indomethacin and ETYA. However, responses to 4 and 8 Hz were not potentiated. The responses to continuous electrical stimulation at 2 Hz were also potentiated by indomethacin and ETYA. This potentiating effect was attenuated when the veins were pretreated with alpha-methyl-p-tyrosine. The responses of the veins to noradrenaline were not altered by either indomethacin or ETYA.3 Prostaglandin E(2) inhibited the responses of the portal vein to electrical stimulation. The magnitude of this inhibition was inversely related to the frequency of stimulation. The responses of the vein to noradrenaline were not altered by prostaglandin E(2).4 It is concluded that potentiation by indomethacin and ETYA of the response of the isolated portal vein is due to an increased release of newly synthesized noradrenaline as a result of inhibition of prostaglandin synthesis.

5,8,11,14-Eicosatetraynoic Acid↗

PubMed1974