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Biomedical subjects

R Grandpierre

Publications and source records attributed to R Grandpierre.

At least 19 recordsLinked to original sources
PubMed1970

Current status of French research on the biological effects of heavy ions in cosmic radiation as observed in high-altitude balloons.

On casual inspection, cosmic rays may not be considered to pose a biological hazard. Nevertheless, the heavy ion component does produce a significant but very local irradiation. This has been confirmed by the hair whitening in black-haired animals. Experiments with black C 57 mice in balloons at 30,000 m altitude show white-haired tufts along the tracks of heavy ions. Histological and radioautographic studies were carried out; the results are reported. Similar investigations on black rabbits gave similar results and confirm those obtained previously with black mice. In the discussion, we report that tissue damage is amplified. This fact is not yet explained, but suggests reconsideration of the calculation of radiation dosage. The ionization distribution induced by heavy ions is analyzed. We point out that along their tracks the dosage is very important; therefore it is necessary to investigate their biological action, particle by particle, according to their energy and their charge.

Animals↗
PubMed1968

[Psychomotor reaction in primates placed in ballistic flight in rockets].

Psychomotor reactions have been studied in Nemestrina Macaques during flights in rockets in which there were periods of weightlessness lasting about 10 minutes. The animals had undergone motor conditioning and responded to a light signal by pressing on a button placed on a panel where there were four other undifferentiated buttons. The lighting of the panel and pressing on the different buttons in reply was recorded with respect to time. Movement was observed by film recording, and electrical activity of the brain was kept under observation by six different recordings of the cortex. Activity of stretching and bending muscles of the legs was recorded, as well as breathing, and heart activity was recorded on an electrocardiogram. These psychological parameters were transmitted to the earth by long-distance measurement during the entire flight. The recordings made it possible to confirm that the absence of the sensation of weight seems to reduce the alertness of the animals. This fact had already been observed in Wistar's rat and cat. The sensor-psychomotor responses undergo important individual variations and depend on the motivation of the subjects. A very well motivated one reacted after a short period of adaption, as it did in the laboratory: one that was much less motivated would not work until after weightlessness has ended, and showed signs of drowsiness. These observations made during the flights in rockets confirm those of Chambers et al., Harris et al., Lilly et al. made in immersion studies; they show the important role of weight in maintaining alertness, but that changes of psychomotor activity are particularly related to motivation.

Animals↗