Biomedical subjects
Publications and source records attributed to R Gottlob.
In 18 rabbits a mixture of 131-J-labeled Triolein and purified olive oil was injected intravenously. Afterwards the radioactivity of the eyes and the brain was measured. The relation of distribution of fat between eye and brain differs markedly, even when the surface tension was controlledly altered by admission of essential phospholipids.
Explore the source record for details and available documents.
We examined the amount of fat that can be forced into the circulation by compression of femora and of heads of the tibia in the very moment of injury. By fractures of diaphyses no considerable reduction of the intraosseous space was achieved and no fat was expelled through the foramina nutritia before the hard cortical bone was splintered. However, considerable amounts of fat were expelled into veins, when the epiphyses of the femora or when the head of the tibia was compressed from medially and from laterally. Even by a purely manual compression some fat was forced to leave the spongiosa by the foramina nutritia. This is explained by the higher elasticity of the spongious bone, permitting a marked space reduction by compression even before a fracture sets in. The mechanism resembles the procedure of opacification of veins by contrast media, injected into the bone cavity under pressure. The significance of these findings for the pathogenesis of clinical fat embolism is discussed.
Explore the source record for details and available documents.
Valvular lesions of the main venous stems are regarded as the predominant cause of the formation of primary varicose veins. Peripheral arteriovenous shunts are regarded as sequelae of varicose veins rather than their cause. The perforating and communicating veins are not involved in the pathogenesis of varicose veins. This opinion is supported by the demonstration of insufficiency of the main superficial venous stems in a series of 200 consecutive cases of primary varicosis, even if only the more peripheral veins were dilated. In addition, histological examination of the uppermost valves in the saphenous veins of patients and experimental studies on post-thrombotic vein valves corroborated these views. The therapeutic importance of high ligature of the saphenous veins is stressed. Removal of the dilated veins by stripping is best, but unnecessarily radical procedures should be avoided. A combination of stripping with sclerotherapy is recommended. The dangers of both forms of treatment are outlined.
Veno-venous autotransplantations of the jugular veins of dogs were performed. The grafts remained patent if an endothelium preserving technique was applied for the dissection of the veins as well as for the anastomotic procedure. The endothelium preserving surgical technique consists in avoiding touching the veins by the hand of the surgeon, by instruments and by swabs. Also the retraction of the severed ends of the vein and of the graft should be avoided as well as the conglutination of the lumina. For this purpose the ends of the veins are kept in extension by atraumatic holding sutures. A progressive shrinking of the anastomotic region was never observed. Moderate stenoses, sometimes seen the first days after the transplantation, regularly disappeared a few weeks later. Ten autografts remained patent without systemic anticoagulation and without creating an arterio-venous fistula.
In human fat embolism we often find different grades of changes in both eyes of a patient. This was experimentally verified in rabbits. The anesthetized animals were held in lateral position so that one eye was continuously higher than the other. Labelled fat was injected intravenously, and then the activity in each eye was measured by a scintillation-counter. By this method a significantly higher rate of fat embolism was found in the upper eye.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The gradient between interior body temperature and external temperature was gradually measured in young pigs, since their skin resembles the properties of human skin. The interior temperature appeared to extend to 2.5 cm under the surface of skin. Then it drops, at first slowly and from 1 cm under the surface rapidly. Tumors or inflammations can only warm the skin directly when their site is 1 cm or less under the skin. Tumors which lie deeper may warm the skin via reflex zones. Warming by heat conduction is prevented by convection. Heating plates inserted 1.8 cm and 2 cm under the skin surface and heated 5 degrees beyond surrounding temperature do not warm the skin surface. This can be demonstrated by thermography. The importance of these results for thermographic tumor diagnosis is discussed.
Explore the source record for details and available documents.