Biomedical subjects

R Goto

Publications and source records attributed to R Goto.

165 records · Page 10Linked to original sources

PubMedDate not supplied

Prostaglandin E1 and tracheal intubation: relationship between the cardiovascular responses and plasma catecholamine concentrations.

A study was carried out on 30 normotensive patients (American Society of Anesthesiologists physical status 1) to investigate whether or not a suppressive effect of 0.3 or 0.6 microgram/kg prostaglandin E1 on the hypertensive response to tracheal intubation was due to inhibition of the increase in plasma catecholamine concentrations following the stressful stimulation. A total of 30 patients in three groups underwent elective surgery. Anaesthesia was induced with 5 mg/kg sodium thiopentone given intravenously and tracheal intubation was facilitated by 0.2 mg/kg vecuronium. Either saline (group A) or 0.3 (group B) or 0.6 micrograms/kg (group C) prostaglandin E1 was administered intravenously 15 s before direct laryngoscopy (lasting 30 s) which was attempted 2 min after administering thiopentone and vecuronium. All groups exhibited significant (P less than 0.05) increases in mean arterial pressure, heart rate, rate-pressure product and plasma noradrenaline concentrations following tracheal intubation, but the increases in mean arterial blood pressure and rate - pressure product were significantly (P less than 0.05) less in groups B and C than in group A. Prostaglandin E1, however, enhanced the increase in plasma noradrenaline concentrations following intubation. Data suggest that attenuation of the pressor response to intubation by prostaglandin E1 may not be due to inhibition of the noradrenaline release stimulated by intubation but to inhibition of noradrenaline-induced vasoconstriction.

Adult↗

PubMedDate not supplied

Use of prostaglandin E1 to treat peri-anaesthetic pulmonary hypertension associated with mitral valve disease.

Severe pulmonary hypertension (PH) can be a critical problem during and after cardiac surgery, since it increases right ventricular afterload resulting in decreased cardiac output. A case of pulmonary hypertension associated with mitral valve disease and resistant to glyceryl trinitrate therapy during surgery is reported. The case was treated successfully with prostaglandin E1 (PGE1), indicating that PGE1 can be used peri-operatively in a patient with refractory PH resistant to glyceryl trinitrate treatment.

Alprostadil↗

PubMedDate not supplied

Limited proteolysis of protein kinase C subspecies by calpain: stimulation by basic polypeptides.

Limited proteolysis of Protein Kinase C (PKC) subspecies by Ca(2+)-dependent neutral protease II (calpain II) was remarkably stimulated by the presence of basic polypeptides, such as H1 histone, protamine, poly-L-arginine, and poly-L-lysine. The stimulatory effect of basic polypeptides was observed for proteolysis of the active form of PKC which was associated with diacylglycerol and phospholipid. The inactive form of PKC was far less susceptible to proteolysis, either in the presence or absence of the basic polypeptides. The basic polypeptides did not appear to interact with calpain II, but caused a conformational change in PKC to make the kinase molecule more susceptible to proteolysis. The relative rates of cleavage of the active form of types I (gamma), II (beta), and III (alpha) PKC by calpain II in the absence and presence of basic polypeptides were 100:48:23 and 100:100:50, respectively. Available evidence suggests that, like calpain I, calpain II may also contribute to the down-regulation or depletion of PKC.

Animals↗