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Biomedical subjects

R Gologan

Publications and source records attributed to R Gologan.

36 records · Page 2Linked to original sources
PubMedDate not supplied

Cell surface antigens induced by herpes simplex virus (HSV).

Among the antigens induced by HSV on the surface of infected cells there are antigens binding anti-HSV antibodies by their combining (Fab) site (HSV-Ag), and others binding antibodies of various specificities, probably through their Fc fragment (IgR). HSV-Ag were demonstrated by cytotoxicity and mixed agglutination tests; IgR were made evident by passive hemadsorption. The ability to induce IgR is especially characteristic of HSV-1 strains, being absent or limited with HSV-2 strains. IgR were not detected on the surface of cells infected by other viruses, such as poliovirus 1, adenovirus 3, measles or vaccinia virus or by viruses belonging to the herpes group (e.g. cytomegalovirus and pseudorabies virus). The ability of bovine infectious rhinotracheitis virus to induce IgR was only slightly expressed. The practical implications of both HSV-Ag and IgR for the techniques aimed at detecting antigens induced by HSV on the surface of infected cells are further discussed.

Animals↗
PubMedDate not supplied

Further immunological evidence for the presence of Fc receptors on the surface of HSV-infected cells.

By coupling passive hemadsorption (PHads) reaction with a complement-mediated cytotoxicity test (CT) it is possible to detect the presence on the surface of hamster embryo fibroblasts of Forssman antigens, hindering the demonstration by PHads of the receptors for the Fc-fragment of immunoglobulins (FcR), possibly induced by herpes simplex virus (HSV). These antigens are acetone- and formol-resistant, but they are destroyed by treatment with methanol or ethanol. However, CT with anti-sheep RBC serum performed in HSV-infected monkey kidney cells is always negative, which proves that the attachment of immunoglobulins to these cells occurs exclusively through their Fc-fragments.

Animals↗
PubMedDate not supplied

[Herpetic etiology of gastric and duodenal ulcer. II. Study in humans].

By inducing experimental ulcers in the rabbit with the type 1 Herpes simplex strain, isolated from the herpes vesicles from a vagotomized patient, the authors demonstrate the protective role of vagotomy, the ulcerogenic capacity of the virus, which can be considered as an etiological factor of human gastroduodenal ulceration. They also discuss the possibilities for a new medical therapy of this disturbance.

Animals↗
PubMedDate not supplied

Serologic diagnosis in the differentiation of autoimmune hemolytic anemias.

A complex serologic study was carried out in 20 patients with autoimmune hemolytic anemias (AIHA). The methods used were: the direct Coombs' test with specific sera anti IgG, IgM, IgA and complement (C), the direct and indirect test with papain treated erythrocytes (at 37 degrees C), determination of cold agglutinin titer and of warm and cold hemolysins. By these investigations using indigenous sera, the 20 cases of autoimmune hemolytic anemia could be classified: a) according to the thermal behaviour of autoantibodies, into warm antibody AIHA -- 15 cases, cold antibody AIHA -- 2 cases and both warm and cold antibody AIHA -- 3 cases; and b) according to the sensitizing globulin, into: IgG type -- 10 cases, IgG + C type -- 7 cases, IgG + IgM + C type -- 1 case, type C + cold agglutinins -- 2 cases.

Agglutination Tests↗
PubMedDate not supplied

Autoimmune hemolytic anemia with warm antibodies complicated with an intercurrent attack of hemolysis with cold agglutinins in a case of Waldenström disease.

The paper presents a case of autoimmune hemolytic anemia (AIHA) with warm IgG antibodies associated with Waldenström's disease in which in the stage of compensated hemolysis after treatment, there appeared a severe hemolytic attack induced by transitory cold agglutinins with high thermal amplitude. The case described is a novelty by the intrication of two autoantibody populations which causes autoimmune hemolysis. The difference from other similar associations is discussed.

Adult↗