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Biomedical subjects

R Goldsmith

Publications and source records attributed to R Goldsmith.

At least 55 records · Page 3Linked to original sources
PubMed1982

Phenobarbitone dosage in neonatal convulsions.

In order to find the optimal dosage schedule of phenobarbitone for neonatal convulsions, four groups of patients were studied. Twelve infants (group 1) received a mean phenobarbitone dose of 9.5 mg/kg a day given intramuscularly for 3 days followed by 5.8 mg/kg a day given intramuscularly and then orally. Six infants (group 2) received a mean intravenous loading dose of 9.5 mg/kg followed by 6.8 mg/kg a day given intramuscularly or orally. Nine infants (group 3) received a mean loading dose of 14.9 mg/kg intravenously followed by a maintenance dose of 5.9 mg/kg a day. Thirteen patients (group 4) received a mean intramuscular loading dose of 15.2 mg/kg followed by 5.9 mg/kg a day. Blood samples were taken regularly and phenobarbitone levels were determined by gas liquid chromatography. A mean intravenous or intramuscular loading dose of 15 mg/kg of phenobarbitone safely achieved therapeutic levels within 2 hours of injection and high therapeutic levels were maintained with a dose of 6 mg/kg a day.

Drug Administration Schedule↗
PubMed1977

The epidemiology of bladder cancer: a second look.

A case-control study among 574 male and 158 female bladder cancer patients and equal numbers of matched controls was conducted between 1969 and 1974 in 17 hospitals in six United States cities. We determined that cigarette smokers of both sexes were at higher relative risk than nonsmokers. Cigarette smoking was responsible for about one-half of male and one-third of female bladder cancer. There was an excess of bladder cancer patients with some previous occupational exposure, such as rubber, chemicals, and textiles. A weak association with coffee drinking, which appeared to be independent of smoking, was found for males. Users of artificial sweeteners were not over-represented among the cases. The authors conclude that the epidemiologic pattern of bladder cancer cannot be fully accounted for by cigarette smoking and occupational exposure and suggest a series of metabolic studies to assess the role of additional factors, such as nutrition.

Adult↗
PubMed1976

Orphan airlift. Enteric pathogens isolated from Vietnamese children immigrating to the United States.

Isolation studies for bacterial and parasitic agents were carried out on stool specimens from Vietnamese infants at the time of their mass airlift to the United States. One or more bacterial pathogens were found in 49% of the 367 stool specimens cultured. The isolates included enteropathogenic Escherichia coli (161), Shigella (16), Salmonella (15), but no Salmonella typhi or Vibrio cholerae. Parasites identified in 88 stool specimens included Giardia lamblia (10), Ascaris lumbricoides (7), and Entamoeba histolytica (1). Transmission of agents to volunteers probably occurred, because 48% of 272 adults questioned had diarrhea shortly after caring for the children, and stool cultures from these adults resulted in the isolation of E coli (105), Salmonella (1), and Shigella (3).

Adult↗
PubMed1975

Planning for a pediatric disaster -- experience gained from caring for 1600 Vietnamese orphans.

The sudden arrival of 1600 Vietnamese orphans in San Francisco required the rapid development of a co-ordinated disaster plan, including the overnight establishment of a 1000-bed pediatric field hospital. The plan required rapid identification and involvement of lay and governmental resources, acute medical triage and provision of ongoing medical care and basic nurturing services and eventual discharge to adoptive families. Because one third of the orphans were under six months of age, conventional nursery resources were insufficient, and a "warehouse" model was implemented. This process required development of a specialized transportation and communication system, the services of 800 physicians, 1400 nurses, and 3200 volunteers and 162 back-up acute hospital beds. Disaster planning in most sizable American cities has focused on the problems of adults. Because of the unusual problem presented by infants and small children, we recommend that cities carefully evaluate their disaster planning with special reference to the needs of children.

Adoption↗
PubMed1975

One-legged pedalling compared with two-legged pedalling on a bicycle ergometer as a basis for assessing physical condition in terms of the cardio-respiratory response to exercise.

An assessment has been made of the linearity of the relationship between oxygen uptake and cardio-respiratory parameters measured during pedalling with one leg on an upright bicycle ergometer. Four young male subjects pedalled at four submaximal grades. Individual regression lines of heart rate on oxygen uptake; minute ventilation on oxygen uptake; and carbon dioxide on oxygen uptake were found to have significantly high correlation coefficients. A comparison was made in 21 healthy males, of mean age 34 years (range 20-61 years), between the effects of pedaliling with one leg or two legs on the heart rate, minute ventilation and carbon dioxide production were significantly higher during work with one leg then with two legs, but there was no significant difference in the heart rates. The oxygen cost of pedalling with one leg instead of two was also higher. The comparisons were made at a standard oxygen uptake of 1.0 1 min minus 1.

Adult↗