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Biomedical subjects

R Gold

Publications and source records attributed to R Gold.

At least 253 records · Page 14Linked to original sources
PubMed1984

Achieving sex education program outcomes: points of view from students and alumni.

Several inherent limitations to secondary school sex education program evaluations are: limited generalizability, lack of longitudinal research, and no clear consensus of program outcomes. With a Bureau of Health Education, Center for Disease Control study as the criterion for program outcomes, a study was undertaken to examine the immediate and long-term impact of sex education upon program participants. Two of the 20 schools in the CDC study identified as having exemplary sex education programs provided access to their students and alumni. Inventories which measured perceived achievement of 33 sex education outcomes were piloted for reliability and validity. Each inventory examined participant changes in knowledge, understanding of self, values, interaction skills, self-esteem, and fear of sex-related activities. Students were surveyed in school; alumni were surveyed through the mail. Response rates ranged from 30 to 100 percent for students and alumni at both schools. Overall there was no statistically significant difference between the perceptions of students and alumni as to achievement of investigated outcomes. Alumni responses at one school did, however, indicate some potentially weak areas of their school's program with respect to values and interaction skills outcomes. It appears that program impact may decrease with time. Thus, isolating and addressing the factors involved may be necessary. This would assist program planners and instructors to strengthen curricula and program activities in order to enhance the overall impact of sex education. The present study supports the notion that positive gains are achieved as a result of each school's sex education program, and these gains remained over time.

Adolescent↗
PubMed1984

Training needs in school health education research.

The purpose of this paper is to review the history of professional preparation of health educators for the conduct of research, to present several major issues and problems related to school health education research, and to identify the characteristics of present training models. Despite the fact that health education can trace its origin to early in this century, it was not until 1953 that a formal statement on research competencies was formulated. Since that time, however, a great deal of activity has been identified. While several issues have been raised regarding research strategies and techniques used by health educators, current training models hold a great deal of promise for strengthening these efforts. The characteristics of such training models are described.

Adolescent↗
PubMed1983

Bacterial meningitis--1982.

The etiologic agents in bacterial meningitis vary with time, geography, and patient age. Predominant pathogens are Escherichia coli, group B streptococci, Listeria monocytogenes, Haemophilus influenzae, Neisseria meningitidis, and Streptococcus pneumoniae. Approximately 70 percent of all cases occur in children under the age of five. The case-fatality rate in the United States in 1978 was 13.6 percent, but it is known that underreporting of cases, and therefore of case-fatalities, occurs. Prevention by vaccine appears to be the ultimate solution, but until a vaccine is developed emphasis should be on rapid diagnosis, improved management, and proper choice of antibiotic.

Age Factors↗
PubMed1983

Ceftazidime alone and in combination in patients with cystic fibrosis: lack of efficacy in treatment of severe respiratory infections caused by Pseudomonas cepacia.

Fourteen patients with cystic fibrosis received 18 treatment courses with ceftazidime for acute respiratory illnesses associated with Pseudomonas cepacia. All patients had severe chronic lung disease. Clinical improvement occurred in only six treatment courses; eight treatment courses resulted in failure and four patients died. Severe illness was characterized by high fever, marked elevation of WBC and ESR. Treatment had no effect on sputum colony counts of Ps. cepacia in 17 of 18 courses, but significantly reduced counts of Ps. aeruginosa in 90% of those patients infected with both bacteria.

Adolescent↗
PubMed1983

Recall of story schema categories by reading disabled adults: effect of mode of presentation.

Stein and Glenn's (1979) story schema provided the framework for testing reading disabled adults' recall of stories that they had heard on tape, read orally, or read silently. For each category of proposition in the story schema, no significant difference was found in the proportion of statements recalled across the three modes of presentation. Further, the pattern of recall of different categories was similar to that which had been exhibited in previous research by normally reading children who heard stories on tape. The findings provide further evidence that the pattern of recall of story schema categories is similar across a variety of subject groups and situations. A possible explanation of this is discussed, as are possible explanations of the specific recall pattern obtained.

Adult↗
PubMed1983

[Locomotor activity and the nucleus accumbens].

Locomotor hyperactivity in rats was induced by microapplication of apomorphine (1 microgram/microliter) or picrotoxin (0.5 microgram/microliter) bilaterally into the n. accumbens and measured in an open field test. After systemic administration, the dopaminolytic drug haloperidol in doses between 0.06 and 0.25 mg/kg abolished both types of hypermotility. After an intraaccumbens injection of haloperidol (0.4 microgram/microliter, bilaterally) or carbachol (1.0 microgram/microliter, bilaterally), the apomorphine hypermotility was completely suppressed whereas the picrotoxin effect remained unchanged. Scopolamine which is known to induce hypermotility after systemic administration was, as methylatropine (1.0 mu/microliter bilaterally), too, without any locomotor effect after intraaccumbens injection. The locomotor inhibitory effect of haloperidol is discussed to be not restricted to its dopaminolytic action within the n. accumbens.

Animals↗
PubMed1982

Antibiotic prophylaxis in cystic fibrosis: inhaled cephaloridine as an adjunct to oral cloxacillin.

The effect of prophylactic antibiotics on bacterial colonization of the respiratory tract and on general progression of cystic fibrosis was studied in a two-year prospective study of 47 mildly to moderately affected patients. One group of patients received inhaled cephaloridine and the other received no inhaled antibiotic; both groups received cloxacillin orally. Carriage of Haemophilus influenzae was greater in the group not receiving inhaled antibiotic (55% vs 20%). Rates of carriage of Staphylococcus aureus (23%). Pseudomonas aeruginosa (greater than 90%). Pseudomonas cepacia (45%), and other organisms were similar in both groups. There were no significant differences between the two groups in incidence of respiratory tract infections or hospital admissions, clinical scores, radiologic scores, or rate of change of pulmonary function. Although continuous antistaphylococcal antibiotic prophylaxis may be successful in suppressing colonization with S. aureus, it may also contribute to the high rates of carriage of Ps. aeruginosa and Ps. cepacia observed in patients with cystic fibrosis.

Administration, Oral↗
PubMed1981

Meningococcal meningitis in familial deficiency of the fifth component of complement.

Absence of the fifth component of complement (C5) by immunochemical assay and marked deficiency by hemolytic assay (less than 0.1%) was found in a family in which the oldest male child had suffered severe and recurrent meningococcemia at age 15 years, two brothers developed meningococcal meningitis four years later (at ages 18 and 14 years), and a sister had the gonococcal arthritis-dermatitis syndrome. Although group-specific meningococcal antibody was present in the sera from all four siblings, serum bactericidal activity against Neisseria meningitidis could be demonstrated only in the presence of exogenous rabbit complement. Serum total hemolytic complement activity was undetectable in all four, but was restored to normal by the addition of purified C5. Subsequently, a second episode of group Y meningococcal meningitis was experienced by one brother and presumed gonococcal arthritis-dermatitis syndrome recurred in the sister. The family is the largest C5-deficient kindred to be reported and emphasizes the importance of C5 in host susceptibility to invasive Neisseria infections. In contrast to the peak incidence of N meningitidis disease in the general population in the first year of life, age of onset of meningococcal infection in these patients and in the 13 previously reported patients with terminal complement component deficiency has usually been in adolescence and early adulthood.

Adolescent↗
PubMed1980

A simple computerized system for plotting the locations of cells of specified sizes in a histological section.

A computerized plotting system is described which generates an outline of a histological section on an oscilloscope screen, and displays within its boundaries the positions of labeled neurons whose coordinates are sent to the computer electronically. Measured cell diameters can also be entered, allowing the computer to generate displays of the distributions of cells within specified size ranges. All data are saved by the computer, and any portion of a distribution may be examined oscilloscopically at several levels of magnification; moreover, three-dimensional displays may be generated wit appropriate programs.

Animals↗
PubMed1980

Effects of atypical antidepressants on LSD potentiated apomorphine hypermotility in rats.

The model of LSD potentiated apomorphine hypermotility [5] was used to classify different atypical antidepressants (danitracen, mianserin, cyproheptadine) and pizotifen. All drugs have been shown to inhibit specifically the locomotor activity potentiating effect of LSD in a low dosage range (0.1-0.5 mg/kg i. p.) without influencing the apomorphine effect. Since there is some evidence that the effect of LSD is due to the inhibition of the activity of serotonergic raphe neurons, the marked antagonizing effects of danitracen, mainserin, cyproheptadine and pizotifen are regarded to be an expression of pronounced antiserotonin activity.

Animals↗