Search PubMed⌕ Search

Biomedical subjects

R Gnauck

Publications and source records attributed to R Gnauck.

15 recordsLinked to original sources
PubMed1988

[Screening for cancer of the large intestine].

A reduction of the high mortality figures from colorectal cancer is possible only when early diagnosis is achieved. This is the aim of annual screening of asymptomatic persons starting at age 45. The only practicable and effective screening method at present is searching for occult blood in feces with the Hemoccult-test. This test should therefore be part of the routine laboratory programme.

Colonic Neoplasms↗
PubMed1987

[Does prolonging the test period improve screening for colorectal cancer?].

Prolongation of Haemoccult-screening from 3 to 6 days in 3540 out-patients resulted in a rise of the positivity rate from 4.1 to 6.75%. This was accompanied by an increase of the detection rate by 10% in cancers and 25% in large adenomas. The predictive value of a positive test for colorectal neoplasia (carcinoma and large polyps together) dropped from 26.7 to 20.9%. More data are needed before general recommendation for change from the standard 3-day-test period can be given.

Colonic Neoplasms↗
PubMed1985

[Does rehydration improve hemoccult screening for intestinal cancer?].

Rehydration, i.e. adding water to the dryed stool specimen before development, is a simple procedure to increase the sensitivity of the Hemoccult test. To counteract an inevitable loss of specificity, a diet omitting red meat and peroxidase-rich vegetables was recommended. During one year the stools of 3430 outpatients of our clinic were tested parallel in the standard manner and after rehydration. Despite of the low-peroxidase diet, rehydration lead to an increase of the positivity rate from 3.5 to 8.4%. Two carcinomas and 12 large adenomas were detected additionally. The predictive value of a positive test for colorectal neoplasia dropped from 20.5 to 13.7%. However, because of the doubling of the positivity rate and consequently the costs of follow-up examinations rehydration cannot be recommended as an improvement in mass-screening for colorectal cancer.

Colonic Neoplasms↗
PubMed1978

[Clinical comparison of hemoFEC with Hemoccult II (author's transl)].

Two technically improved methods of testing for occult blood in stool--hemoFEC and Hemoccult II--were compared by parallel tests in 1500 successive unselected out-patients. HemoFEC was positive in 1.9%, Hemoccult in 2.3%, the difference is not statistically significant. But there was a difference in the colour development of the two tests. Six cases of carcinoma, 14 of large polyps and six other sources of bleeding from the colon were revealed in the course of this study.

Colonic Neoplasms↗
PubMed1978

Hemocult screening.

Explore the source record for details and available documents.

Colonic Diseases↗
PubMed1977

[Screening for colorectal cancer with the Haemoccult test (author's transl)].

Results are reported of a 5 year trial with the Haemoccult stool-test in a diagnostic center (DKD), and of a 1 year trial in the offices of 110 physicians. In the DKD 8 000 patients were tested: In a non-selected group 2,4% and in a selected one 3,8% of tests performed turned out to be positive; the diagnosis of carcinoma of the colon or rectum was established in 32 of these cases and 45 large polyps were traced. In most of the offices the test was positive in less than 3% of the patients tested, 57 of these patients had a carcinoma and 26 polyps. In 54 of all 89 cases with carcinoma and in 46 out of 71 polyps the lesions could not be found by digital or rectoscopic examination, due to a higher localization; 17 of the cancer patients were asymptomatic except for a positive Haemoccult test. Using only 3 tests per patients, 7 out of 96 colorectal cancers and 27 out of 98 large polyps were negative. 6 haemoccult tests to be done on three successive stools (as originally proposed by Greegor) are recommended as a yearly routine procedure in all persons about 40 years of age for early detection of carcinoma or polyps of the colon.

Colonic Neoplasms↗