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Biomedical subjects

R Gil

Publications and source records attributed to R Gil.

At least 199 records · Page 11Linked to original sources
PubMed1984

[Reversible paraplegia following intrathecal injection of high doses of human gammaglobulins in the treatment of low-grade tetanus. 4 cases].

Intrathecal serotherapy appears to be effective in the treatment of tetanus, and it has been claimed that human immune globulins are innocuous. In the 4 cases reported here reversible paraplegia developed a few hours after intrathecal injection of 1500 to 2000 UI of human immune globulins prepared by the French Blood Transfusion Centre. We believe that paraplegia was related to the high doses administered. The fact that intrathecal serotherapy is normally used in severely ill patients whose impaired consciousness precludes motricity and sensitivity testing may explain why this complication has not previously been reported. The need for high doses of intrathecal immune globulins is discussed. It has recently been suggested that high doses are superior to low doses. We consider that this form of treatment is justified, even in the least severe forms of tetanus, but we feel that doses higher than 1000 IU are not without danger.

Aged↗
PubMed1984

The role of the nurse in hospital marketing.

The nurse is introduced as a vital component of the hospital's marketing process. As the major provider of patient care, teacher, counselor, and patient advocate, the nurse has a direct impact on the quality of care delivered and ultimately, the patient's choice of health care delivery site. Marketing strategies for nurses include daily rounds, constructive communication, physical appearance, and educational level. Through such strategies, nurses play an active role in increasing patient revenue.

Humans↗
PubMed1984

[Morvan's fibrillary chorea and acrodynic syndrome following mercury treatment].

A 31 year-old inhabitant of French Guiana was prescribed mercuric iodide per os for two and a half months. Shortly before the end of the treatment he developed fasciculations in the trunk and particularly the lower limb muscles, distal painful paresthesias with vasomotor disorders, episodes of excessive perspiration and palmoplantar erythema, moderate fluctuating hypertension, progressive loss of weight and irritability with insomnia. Clinical and electrical signs of neuropathy were lacking. The clinical picture was that of Morvan's fibrillary chorea with acrodynia, the conditions of onset strongly suggesting a mercurial intoxication. Blood and particularly urine mercury levels were elevated. Administration of dimercaprol (BAL) considerably increased urinary excretion of mercury and there was progressive improvement and finally recovery after two months of BAL treatment. This case exemplifies the possible co-existence of fibrillary chorea and acrodynia. Whereas in many cases of fibrillary chorea a precise etiology cannot be determined, the affection can be induced by mercury as by gold administration. The fact that cases of fibrillary chorea due to mercury poisoning are rarely reported may be the result of individual patient hypersensitivity or particular metabolic absorption and excretion features of mercury. This case cannot be included within the continuous activity syndrome of muscle fibers described by Isaacs, since muscle contractures were absent and there was associated acrodynia. Moreover, there was no latent polyneuropathy, in spite of the intense fasciculations. It must be concluded, therefore, that in spite of its rarity fibrillary chorea should keep its semiologic autonomy.

Acrodynia↗
PubMed1984

Alloantibodies to PHA-activated lymphocytes detect human Qa-like antigens.

Platelet-absorbed sera were obtained from placental clots after delivery by multiparous women. These sera contained antibodies that react with PHA-activated lymphocytes after the latter are separated from peripheral blood and expanded with interleukin 2. These alloantibodies did not react with resting T lymphocytes, but reacted with B lymphocytes, PHA-activated lymphocytes, or both types of cells obtained from some but not all of the T lymphocyte donors. Reactions against B lymphocytes were associated with anti-Ia-like antibodies on the basis of blockage by turkey antibodies against human Ia. Reactions against PHA-activated lymphocytes that were blocked by turkey anti-beta 2m were classified as 'HT'. Several antibodies were found to give reactions to HT determinants in separate panels of lymphocytes from Tel Aviv and Boston. The reproducibility of the cytotoxicity reactions was 89%. Altogether, 23 of 1100 sera were found to contain these reactions when screened by a panel of cells obtained from 30 individuals of known HLA phenotypes. Correlation coefficients were determined for all reactions, determining three clusters of significant reactivities: sera 965 and 1032 defined HT-2; sera SF48 and 1642 defined HT-3; and sera 1136, 1605, 1014, and 1227 defined HT-4. HT-2 was found to be inherited with HLA in 11 siblings from four families. Some of these antibodies react with antigens (non-HLA) containing beta 2m that were expressed on activated lymphocytes, but not on resting T lymphocytes, and did not react with thymocytes from the same donors of the peripheral lymphocytes. Our findings suggest that the HT alloantigens expressed on lectin-activated lymphocytes are class I differentiation antigens of a system analogous to the murine Qa system.

Antigens, Surface↗
PubMed1983

[Spinal meningeal hemorrhage of tumor origin].

Intraspinal tumors with subarachnoid hemorrhage are exceptional. They are most often localized at the cauda equina. Ependymoma is the most common tumor. Low back pain followed by headache (Fincher syndrome) should suggest hemorrhage originating from a low lesion.

Adolescent↗
PubMed1983

[Optokinetic nystagmus and the Tensilon test in myasthenia].

Horizontal optokinetic nystagmus was measured before and after the intravenous administration of 10 mg of Tensilon in 12 patients with myasthenia gravis; 11 patients showed an increase of amplitude; this measure seems to be a reliable test for the diagnosis of myasthenia but the increase of frequency of optokinetic nystagmus is less specific. The increases of amplitude in the same patient may show important variations between the two eyes and depending on the direction of nystagmus; however, the greatest response is often observed in the optokinetic nystagmus which was initially the weakest.

Adolescent↗
PubMed1983

Granulocyte specific cytotoxic antibodies in pregnancy and multitransfused sera.

The myeloid cell line K562 was used to screen for specific antibodies in sera obtained from pregnant women and multitransfused patients. The alloantisera thus procured reacted with random granulocytes in a pattern suggestive of a polymorphic system. Some antibodies were found to react only in the cold. A simple reproducible method for the simultaneous separation of granulocytes and lymphocytes for microcytotoxicity is described.

Antibody Specificity↗
PubMed1982

[Involvement of oculomotor nerves. A little-known complication of Horton's disease].

Third, fourth and sixth cranial nerve palsy is a less common complication of giant cell arteritis than ischemic optic neuritis. Nevertheless, it occurs in at least 10% of cases. A case of giant cell arteritis with third nerve palsy which resolved under corticosteroid therapy is reported. The incidence of ocular complications is assessed from a review of the cases previously seen in the department and of data from the medical literature. The authors believe that the index patient has ischemic neuritis rather than myositis. It is concluded that giant cell arteritis should be considered at an early reversible stage.

Aged↗
PubMed1982

[Liver explant cultures from rats of various ages (author's transl)].

Liver tissue from rats of different age has been cultured. The samples were obtained by surgical biopsy. A relationship between the obtained growth in culture and the animal age was established. A relationship between the obtained growth in culture and the animal age was established. The liver from young and weanling rats grows larger and earlier than the adult liver. The cells obtained in culture have been classified in five different types according to morphological criteria.

Age Factors↗
PubMed1981

[Features of hepatocytes isolated from rats poisoned with N-nitrosomorpholine].

We have studied the behavior in culture of hepatocytes from NNM-intoxicated rats for one week. We have not seen any morphological difference with respect to the controls, but we have observed a longer survival time permitting a second culture from the primary one. As a possible explanation we suggest that NNM, after acting one week upon the hepatic parenchyma, induces some disdifferentiating mechanism of the hepatocytes that, although it has no morphological expression, allows these cells to have a longer survival time in in vitro cultures.

Animals↗