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Biomedical subjects

R Giancola

Publications and source records attributed to R Giancola.

At least 19 recordsLinked to original sources
PubMed1999

Spontaneous dissection of coronary artery in a patient with ascending aortic aneurysm and aortic valve regurgitation.

Spontaneous coronary artery dissection is a rare cause of myocardial infarction associated with a significant high morbidity and mortality. It usually occurs in relatively young patients and it is frequently found at autopsy. We report a case of a 42-year-old woman, who underwent resection of subaortic diaphragm ten years earlier presenting with postero-lateral myocardial infarction. Coronary arteriography revealed a dissection of the left main stem extending distally to the left anterior descending artery (LAD) and circumflex artery (Cx); occlusion of the postero-lateral branch of the Cx; severe aortic valve regurgitation and ascending aortic aneurysm. She was successfully operated on in emergency and underwent myocardial revascularization and separate replacement of the aortic valve and the ascending aorta. In this specific case of coronary dissection and severe aortic regurgitation it is mandatory to perform surgery in emergency to limit infarction evolution and avert loss of life.

Adult↗
PubMed1998

Hypotonically induced calcium increase and regulatory volume decrease in newborn rat cardiomyocytes.

The effect of cell swelling on intracellular calcium concentration ([Ca2+]i) was studied in newborn rat cardiomyocytes. Hypotonic cell swelling induced a fast and transient [Ca2+]i increase (hypotonically induced calcium increase, HICI; 388±47 nM, n=14). HICI was not inhibited by cyclopiazonic acid (CPA), an inhibitor of sarcoplasmic Ca2+-ATPase, nor ryanodine (an inhibitor of calcium-induced calcium release), whereas it was abolished (11±19 nM, n=5) in the absence of external calcium. Thus, HICI appeared to depend exclusively on entry of external calcium. Gadolinium ion (Gd3+), a generic inhibitor of stretch-activated cation channels (SACs), was unable to affect HICI (353±79 nM, n=6). Similarly, HICI was unaffected by internal Na+ depletion and external Na+ omission. These results suggest that neither Gd3+-sensitive SACs nor Na+-Ca2+ exchange is responsible for HICI. Conversely, HICI was inhibited by diltiazem (42±4 nM, n=3) and by membrane predepolarization (40±18 nM, n=5), suggesting an involvement of L-type voltage-activated calciumchannels. Cardiomyocyte swelling was followed by a regulatory volume decrease (RVD). The putative role of HICI in volume regulation was studied by removal of external calcium. This procedure significantly slowed RVD but did not abolish it. In conclusion, newborn rat cardiomyocytes exhibit an external-calcium-dependent HICI which contributes partially to the RVD.

Animals↗
PubMed1985

[A case of osteomyelitis caused by salmonella in a subject with thalassemia-drepanocytosis].

The authors show a case of osteomyelitis due to salmonella, they had the opportunity to observe in a patient suffering from thalassemia and sickle-cells disease in heterozygote from. They describe all the clinical and instrumental ascertainments performed and the surgical treatment effected at level of the osteomyelitic focus with subsequent recovery.

Anemia, Sickle Cell↗
PubMed1985

[Surgical treatment of humeral epicondylitis].

The authors show the remote reviewing of 41 patients suffering from tenuis elbow, surgically treated from 1975 up to 1983. The results at the checking appear excellent in 67,4%, good in 20,9%, sufficient in 9,4% and, at last, poor in 2,3%.

Adult↗
PubMed1985

[Osteochondritis dissecans: a rare localization].

The authors show a non-frequent location of osteochondritis, occasionally diagnosed owing to a trauma. In consideration of the practically inexistent painful symptomatology, no specific therapy was performed. The clinical and radiographic checking was effected after eight months.

Adult↗
PubMed1985

[Frieberg-Kohler disease. Long-term review of the surgical treatment in 20 cases].

The authors show the reviewing of twenty patients suffering from Frieberg-Kohler's disease, surgically treated from 1975 up to 1980. The surgical intervention had been suggested by the important painful symptomatology, resisting to the conservative therapy. At checking, the patients were all satisfied with the results of operation, and could start again with their usual job.

Adolescent↗
PubMed1985

[Dupuytren's disease and diabetes mellitus].

The AA. study the relationship between diabetes mellitus and Dupuytren's disease. The examination of 300 patients, after a palmar aponeurectomy intervention, shows a percentage of 14.3%, equivalent to 43 patients.

Adult↗
PubMed1985

[Relation between L5 sacralization and hernia of the lumbar disk].

The AA. present a study on the relationship between the most common congenital malformation of the lumbosacral passage: the sacralization of L5 and lumbar disc hernia. The examination of 200 cases of lumbar disc hernia shows a sacralization incidence of 11.5%.

Adolescent↗
PubMed1980

[Septic arthritis of the knee in adults. Treatment with closed irrigation-drainage].

The Authors report their experiences in Redon tube closed washing-drainage treatment of secondary septic arthritis in adults. This technique, used at an early stage as an alternative to needle drainage, does not require plaster immobilisation and has allowed a good residual function to be obtained. In case of absence of response to the treatment, it is considered inadvisable to persist; in such case the surgical approach with "functional treatment", and with or without combined synovectomy, is recommended.

Anti-Bacterial Agents↗