Biomedical subjects

R Gerner

Publications and source records attributed to R Gerner.

At least 37 records · Page 2Linked to original sources

PubMed1981

[Determination of the protein binding capacity of corticosteroids from the serum (author's transl)].

This article describes a method which enables determination of the binding capacity of the corticosteroids from untreated serum with relatively little effort. The method is based on the principle of competitive protein binding. The binding capacity is given for cortisol and DOC and it is shown that progesterone enters into a bond with CBG.

Binding, Competitive↗

PubMed1981

The effects of sleep deprivation on average evoked responses in depressed patients and in normals.

The effects of a single night of sleep deprivation on the amplitude and amplitude/stimulus intensity function of the visual evoked potential (EP) were studied in 16 patients with primary affective disorder and 20 normal controls. Visual EP amplitude and amplitude/intensity slopes tended to increase after sleep deprivation in the patient group, a direction found in other studies to be associated with a spontaneous mood improvement and changes with antidepressant medication. In contrast, normal volunteers who showed little or no mood elevation showed generally opposite EP effects. Taken together, the results suggest a similarity in the neurophysiological effect of sleep deprivation between patient and antidepressant medication in depressed patients.

Adolescent↗

PubMed1980

[The behaviour of endocrinal parameters under prophylaxis of hyaline membrane disease with glucocorticoids (author's transl)].

Prevention of hyaline membrane disease with glucocorticoids produces suppression of the hypopituitary-adrenocortical axis of the mother as well as of the foetus. The extent of the suppression is significantly higher under medication with the 9 alpha-fluorinated preparations, betamethasone and dexamethasone, than under medication with 16-methyleneprednisolone. Increases in the concentration levels of the mineralocorticoid DOC are to be expected in 37% to 50% of the patients, depending on the administered corticoid. The percentage of increase is 150% under 16-methyleneprednisolone and 220% under betamethasone and dexamethasone.

Adrenal Cortex Hormones↗

PubMed1980

Treatment of geriatric depression with trazodone, imipramine, and placebo: a double-blind study.

Sixty unipolar depressed geriatric outpatients were subjects in a double-blind study of a new antidepressant, trazodone, versus imipramine and placebo. Over the four week study, patients in the two active medication groups improved significantly compared to placebo on both observer and self-ratings. Although imipramine and trazodone had similar therapeutic efficacy, trazodone was judged to have fewer side effects than imipramine, suggesting that trazodone may have particular clinical utility in the geriatric population which is especially vulnerable to cardiovascular and anticholinergic side effects.

Aged↗

PubMed1980