[Modalities of tumor extension in epitheliomas of the larynx: therapeutic deductions].
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Biomedical subjects
Publications and source records attributed to R Gerard-Marchant.
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On the basis of histological sections and cytological smears in 110 cases, the "reticulosarcoma" (exclusive of Ewing's sarcoma and reticulosarcomas of bone marrow) were divided into two varieties: histiocytic types and histioblastic types.The correlation between the histological and cytological evaluation was excellent in each case; only those tumours classified as histiocytic presented a continuous and abundant network of reticulin.The histioblastic type predominated in the male sex. The difference in the clinical expressions of the two varieties is not statistically significant, except as to the frequency of cutaneous lesions: 27.7% in the histiocytic type and 2.6% in the histioblastic type.While the duration of their evolution is not different, only the histioblastic type is transformed into leukaemia, which is of the "monoblastic" type: this transformation was observed in 17.5% of cases, while it was never observed in histiocytic type.
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Among malignant tumor of the orbit in children, rhabdomyosarcoma remains the most frequent; it should be suspected on any unilateral exophthalmia. Twenty cases have been treated in the "Institut Gustave Roussy" (1960--1975). It can be shown with polychimiotherapy and a better coordination in timing of the other therapies, the survival rate improved clearly. In addition, since 1972 more localized forms have been treated. In the future, the survival rate is supposed to improve yet, if the diagnosis is made earlier. In such conditions a recovery with few inconveniences may be expected. Exenteration is an important mutilation and do not supply a better protection. A secondary inucleation due to complications of radio-therapy is not an exception. However a prothesis will be possible later.