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Biomedical subjects

R Gay

Publications and source records attributed to R Gay.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

Characteristics of cellulose colonization by a mesophilic, cellulolytic Clostridium (strain C401).

Using the technique of incorporation of 3H-thymidine into DNA, we describe colonization properties of an anaerobic, mesophilic, cellulolytic Clostridium, strain C401. This method took into account both bacteria which adhered and those which did not adhere to the substrate. The observed generation time (7.5 h) was faster than that detected (26 h) with other methods. Under the conditions used, the end of growth was characterized by a sharp release of biomass. A depletion in the supply of carbon source and therefore, of the adhesion site, was responsible for this release.

Bacterial Adhesion↗
PubMedDate not supplied

[Psoriatic onycho-pachydermo-periostitis of the big toe. Anatomo-clinical study and physiopathogenic approach apropos of 4 cases].

The authors report 4 cases of rheumatoid psoriasis in which involvement of the great toe, associating psoriatic onychosis, thickening of the distal soft tissues and osteo-periostitis of the distal phalanx without lesions of the interphalangeal joint, is the result of a direct repercussion of the ungual lesion on the distal phalanx. This is explained by very close anatomic links between nail and distal phalanx. They advocate the term of psoriatic onycho-pachydermo-periostitis of the great toe or OP3GT, when referring to this radio-clinical syndrome highly evocative of rheumatoid psoriasis.

Adult↗
PubMedDate not supplied

[Pulmonary oxygen transfer under a respirator in anesthesia and resuscitation].

The resistance of the passage of oxygen from air to blood is estimated in measuring P(A-a)O2. This index varies with FIO2. P(a/A)O2, the index proposed by GILBERT and KEIGHLEY [18], expresses PaO2 as a percentage of PAO2. This index would be independent of FIO2. Two groups are studied. Patients of the first group (n = 22) are artificially ventilated in intensive care for severe parenchymal lesion. Those of the second group (n = 25) have no notable history of pulmonary disease and are anaesthetized and hooked up to a respiratory for surgery. Blood gases are measured and the transfer indices calculated for increasing FIO2 (0.4, 0.6, 0.8 and 1). Under conditions of anaesthesia, the effect of thermic decrease on PaCO2 is dampened by maintaining a constant PACO2 during measurement. P(a/A)O2 does not vary significantly as a function of FIO2 in the intensive care group, whereas the results observed in the anaesthetized patients are substantially dispersed. Factors which are susceptible to affect oxygen transfer as well as the effects of FIO2 increase are discussed. P(a/A)O2 stability observed in intensive care is probably related to the predominant effect of venous admixture, which is hardly affected by variations in FIO2. In anaesthesia, resistance to the transfer of oxygen appears to be linked mainly to changes in the distribution of the ventilation/perfusion ratio (reduction in CRF; pharmacological effect of oxygen on pulmonary vascular reactivity). These phenomena lead to alveolar instability and a variable shunt effect.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Disease↗
PubMedDate not supplied

[Periodic macromolecule syntheses in synchronized cultures of species belonging to the "Rhodococcus" genus ("Rhodochrous" group) (author's transl)].

The synthesis of total proteins, total RNA and DNA in exponential synchronous cultures of species belonging to the Rhodococcus genus (Nocardia restricta and N. canicruria) has been studied by chemical methods and pulsed incorporations of labelled precursors in the acid-insoluble fraction. The replication of DNA is discontinuous. Syntheses of RNA and proteins are periodic: they happen during two main periods during the time necessary for a doubling of the cell mass. A slowdown of these syntheses occurs during the DNA replication. This periodicity allows to explain the regular discontinuities previously observed on the absorbance curves of synchronous cultures. The discontinuous pattern in the macromolecules synthesis of Rhodococcus allows a comparison with the cell cycle of some lower eukaryotes but is different from the cycle of fast-growing bacteria.

Bacterial Proteins↗