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Biomedical subjects

R Gava

Publications and source records attributed to R Gava.

50 records · Page 3Linked to original sources
PubMed1984

[Treatment of refractory hypertension with combined minoxidil and captopril in low doses].

Twelve patients with severe hypertension of different causes, resistant to conventional antihypertensive agents and also to maximum doses of either minoxidil or captopril added to other combinations, were effectively controlled with the association of small doses of minoxidil and captopril plus a diuretic and a beta-blocker. The untoward effects which were previously present in all the patients with maximum doses of minoxidil and in one of the patients treated with captopril disappeared or greatly diminished shortly after this association was started. The different mechanisms of action and opposite side effects of minoxidil and captopril provide the rationale for a combined treatment with the two drugs.

Adrenergic beta-Antagonists↗
PubMed1983

Comparison of sotalol and propranolol in mild to moderate essential hypertension.

The controlled, open, cross-over study reported in this article demonstrates that sotalol and propranolol administered twice daily to 20 patients provide an equally satisfactory control of moderately elevated blood-pressure for 24 hours. The average daily dose of sotalol and propranolol required to achieve this effect was 200 +/- 95 mg and 154 +/- 90 mg respectively. No important side-effects were observed.

Adult↗
PubMed1983

[Hypotensive effect and changes of arterial pressure variability induced by treatment with labetalol in patients with slight and moderate arterial hypertension].

To evaluate the hypotensive efficacy of labetalol (600 mg/day) six mild to moderate hypertensive patients were studied by the indirect continuous blood pressure monitoring with the Del Mar Avionics Pressurometer 111 degrees. This technique gives a much larger number of blood pressure values in a greater variety of conditions than the conventional Riva-Rocci sphygmomanometer. After one month of continuous therapy there was a substantial reduction in systolic and diastolic pressure. The increased index of Kurtosis revealed a decreased blood pressure variability. The circadian changes of blood pressure were not significantly affected, but the morning peak was smoothed by labetalol.

Blood Pressure↗
PubMed1982

Effects of captopril on renal function in hypertensive patients.

The effects of captopril (SQ 14225) on renal function were studied in 10 hypertensive patients. After 7 weeks of treatment (75 to 500 mg/day) renal plasma flow was practically unchanged and glomerular filtration rate was only slightly decreased despite a significant decrease in blood pressure. All indexes of glomerular capillary permeability and of tubular anatomic integrity remained normal during the treatment period.

Adult↗
PubMedDate not supplied

Cytosolic levels of an estrogen-induced breast cancer-associated peptide (TFF1/pS2) in colorectal cancer: clinical significance and relationship with steroid receptors.

BACKGROUND: The Trefoil Factor 1 (TFF1/pS2), a peptide consisting of 60 amino acids, is the most abundant estrogen-induced messenger RNA in MCF-7 breast cancer cells and is also expressed by colorectal carcinomas. The objective of this work was to evaluate the cytosolic TFF1 content in colorectal carcinomas, its possible relationship with estrogen and progesterone receptors as well as with clinicopathological tumor parameters, and its potential prognostic significance. METHODS: Cytosolic TFF1 levels were examined by immunoradiometric assay in 178 patients with resectable colorectal cancer. The mean follow-up period was 32 months. RESULTS: There was a wide variability of cytosolic TFF1 levels in tumor-surrounding mucosa samples (0.09-42.5 ng/mg protein) as well as in tumors (0.01-270 ng/mg protein). Comparison of paired mucosa and carcinoma samples showed significantly higher TFF1 levels in tumors (mean: 17.1 ng/mg protein) than in mucosa samples (10 ng/mg protein) (p = 0.027). TFF1 levels were significantly higher in mucosa samples surrounding distal colon and rectal tumors (p = 0.0001) and in tumor samples obtained from older patients (p = 0.007). However, there were no significant differences in tumor TFF1 levels with respect to clinicopathological parameters such as the patient's sex, tumor location, stage, histological grade, ploidy, S-phase, or tumor estrogen and progesterone receptors. In addition, there was no significant relationship between tumor TFF1 levels and disease outcome. CONCLUSIONS: TFF1 may play an as yet undetermined role in the tumorigenesis of colorectal carcinomas. However, cytosolic levels of TFF1 do not seem to have any prognostic significance in colorectal carcinomas.

Adolescent↗
PubMedDate not supplied

[Enoxacin].

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Adult↗
PubMedDate not supplied

[Uric acid].

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Adult↗
PubMedDate not supplied

[Theophylline].

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Chemical Phenomena↗