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Biomedical subjects

R Gatti

Publications and source records attributed to R Gatti.

At least 181 records · Page 10Linked to original sources
PubMed1984

Plasmapheresis versus lymphoplasmapheresis in rheumatoid arthritis: immunologic comparisons and literature review.

Eight patients with Functional Class III, seropositive, erosive rheumatoid arthritis unresponsive to remittive drugs each underwent nine aphereses over 3 weeks. Four had a 40-ml/kg plasma exchange and four others had a 40-ml/kg plasma exchange plus a mean 5.67 X 10(9) lymphocyte depletion. Both groups appeared to improve clinically. T and B cell counts and OK T4 and OK T8 ratios decreased in the lymphoplasmapheresis group. Phytohemagglutinin stimulation decreased in lymphoplasmapheresis and increased in plasmapheresis patients with significant comparisons (p = 0.02). These findings confirm and extend previous work. Plasmapheresis and lymphoplasmapheresis appear to have fundamentally different actions on lymphocyte function.

Adult↗
PubMed1984

Comparative study of rotavirus strains of bovine and rabbit origin.

Newborn calves were susceptible to infection with a rotavirus strain isolated from rabbits and, conversely, rabbits 4-5 weeks of age became ill and some died when inoculated with the rotavirus strain of bovine origin. However, the latter isolate appeared to be more virulent than the rabbit isolate in either calves or rabbits. Moreover, in reciprocal cross protection tests, carried out in calves and in rabbits, the rabbit rotavirus antiserum afforded only weak protection to challenge infection with either the homologous or the heterologous virus. By contrast, the protective level of the bovine rotavirus antiserum was relatively high.

Animals↗
PubMed1984

Carnitine deficiency as the possible etiology of idiopathic mitral valve prolapse: case study with speculative annotation.

UNLABELLED: Idiopathic mitral valve prolapse (IMVP) is a very common cardiac abnormality that may be linked to carnitine deficit (inadequate nutritional intake or absorption). One patient with IMVP and related symptoms that were resistant to drug therapy was fully studied. Free plasma carnitine and 24-hour free urine carnitine were measured twice, 10 days apart, after an overnight fast. FINDINGS: Free plasma carnitine 23 and 28 microM/L (our laboratory N=38+/-2 microM/L); free urine C 25 and 44 microM/24 hr (N=255+/-66 microM/24 hr); FFA 0.88 mEq/L, Duncombe method (N=0.09-0.60); LDL 42% (N = 44-65); cholesterol 161 mg/dl (N = 180-280); triglycerides 84 mg/dl (N = 50-172); SGOT 79 MU/ml (N = up to 40); SGPT 147 MU/ml (N = up to 40); OCT 11.2 MU/ml (N = up to 10.0); aldolase 11.5 MU/ml (N = up to 3.1, Bruns method). Deltoid biopsy: light microscopy showed the presence of optically empty vacuoles; electron microscopy showed lipid droplets near the subsarcolemma area and intermyofibrillar spaces. The mitochondria contained electron dense granules. The electromyogram was also abnormal. In a random sample of four patients with IMVP and related classic symptoms, we have found low levels of plasma and/or urinary carnitine in each case. This study may be the first step towards L-carnitine therapy for what has previously appeared to be idiopathic cardiomyopathy.

Journal Article↗
PubMed1984

[The fine structure of spermatozoa from Chiroptera].

The fine structure of hibernating bat spermatozoa (Vesperugo savi and Rinolophus f.e.) has been studied by SEM and TEM, during their prolonged storage in female reproductive tract. The main morphological aspects of sperm portions: head, neck, middle piece, principal piece and terminal piece have been described. The Author besides comparisons with other mammalian species and Chiroptera, suggests some typical ultrastructural features of these Chiroptera, as the complete absence of vacuoles in the nuclear chromatin and corrugated structures in the post-acrosomal zone. Moreover electron-dense material in the subacrosomal space and three mitochondria in the neck were observed. Two areas of fusion between outer dense fibers 3 and 8 and the inner ends of the respective longitudinal columns of the fibrous sheath and asymmetrical arrangement of the outer dense fibers of the principal piece were found.

Animals↗
PubMed1984

[Synthesis of various acyclic analogs of pyrimidine nucleosides].

As acyclic analogues of pyrimidine nucleosides, 1-[2-(2,3- dihydroxypropyloxy )ethyl]pyrimidines (III a-c) and 1-[[3-(2,3- dihydroxypropyloxy )-2-hydroxy]propyl]pyrimidines (III d-f) were synthesized and tested for in vitro activity against herpes simplex virus type 1. The compounds exhibited no significant antiherpetic activity.

Antiviral Agents↗
PubMed1983

[Ultrastructure of the lymphatic vessels of the urinary bladder].

The fine structure and morphological aspects of superficial and deep lymphatic vessels of Chiroptera' bladder (Vesperugo savi and Rinolophus f.e.) have been studied, under seasonal, physiological conditions of different lymphatic flux (winter lethargic state and summertime). The endothelial walls of subepithelial, intramuscular and subserosal-peritoneal, lymphatic networks show an uninterrupted course together with both simple and complex intercellular contacts, constantly jointed by specialized junctional complexes, such as zonulae adhaerentes and occludentes. The abluminal surface is often almost entirely encircled by a thick layer of fibrillary connective tissue. Seasonal cytological modifications of possible importance and morphological aspects typical of the each individual network have not been detected in the lymphatic endothelium. On the other hand the abundance distribution of clear intracytoplasmic vesicles and the frequent occurrence of micropinocytotic vesicles in the luminal and abluminal membrane surface have been shown. Canalicular structures have also been demonstrated, even if quantitatively less numerous with respect to those seen in the chiliferous vessels of the same species of Chiroptera. The Authors believe that most of the transendothelial transport in the above mentioned lymphatic vessels occur through the micropinocytotic vesicles and also through the intra-endothelial channels made up by the vessel wall, without any intervention of intercellular contacts or specialized junctions. The possible role of substances within the interstitium in inducing the appearance of canaliculi in the endothelial wall is discussed.

Animals↗
PubMed1983

[The fine structure of the lymphatic vessels of the urinary bladder of small Chelonia (Testudo graeca and Emys europea)].

The fine structure of lymphatic vessels in the subepithelial, intramuscular and subserosal layers of the bladder of small Chelonia (Testudo graeca and Emys europaea) have been investigated during the winter and summer seasons. The vessels are made up of flat endothelial cells, which abluminal surface is encircled by a thick layer of connective fibrils. Peripheral cytoplasmatic processes of adjacent endothelial cells are connected by specialized junctional complexes (zonulae adhaerentes and occludentes) and show an uninterrupted course. No seasonal cytological modification is noted, whereas some morphological aspects typical of each individual network can be detected. Comparative aspects and the presence of intra endothelial channels are stressed. The latter, together with micropinocytotic vesicles, seem to play an essential role in the exchanges with the interstitium, while the intercellular junctions do not undergo any modification.

Animals↗
PubMed1983

[The fine structure of the efferent ductules of the duct of the epididymis of some Chiroptera (Vesperugo savi and Vesperugo piccolo)].

The fine structure of the epithelium lining the ductuli efferentes and the ductus epididymis of Chiroptera (Vesperugo savi and Vesperugo piccolo) has been investigated. The epithelium of ductuli efferentes is composed of two cell types: principal and ciliated cells, while the ductus epididymis shows four cell types: principal, clear, basal cells and lymphocytes. Cytological differences in principal and clear cells are described, which allow to subdivide epididymis into three regions: head, body and tail. It has also been possible to recognize in these cells both an absorbing and a synthetic function. Cytological features of principal and clear cells in relation to epididymis' function of spermatidic maturation are discussed.

Animals↗
PubMed1983

[Seasonal cyclic changes of the epithelium of the epididymis].

The cyclical and seasonal modifications of the various epididymis regions (ductuli efferentes, head, body and tail) of Chiroptera (Vesperugo savi and Vesperugo piccolo) have been investigated. The ultrastructural seasonal features noticed in the ductus epididymis and principal, clear cells content confirm a double function (absorbing and synthetic) in these cells. Beside it, they seem to underline a close relationship with the phases of spermatogenesis and the eventually significant contributions of the epididymis regions to the spermatozoa maturation.

Animals↗
PubMed1983

[Early ultrastructural findings on lymph node sinuses].

Submandibular and mesenteric lymph nodes of Chiroptera (Rinolophus f.e. and Pipistrellus p.) display a marginal sinus, located between the capsule and the cortical parenchima. There are also trabecular sinuses, which deepen in both the cortical and paracortical zones and medullary sinuses in the zona medullary. All the above mentioned sinuses are made up of a distinct endothelial cell wall lying on a variably thick layer of amorphous substance and collagen fibers. Moreover, the endothelial subcapsular wall of the marginal sinus and the endothelium lying the connective tissue septa form a continuous layer, whereas the endothelium adjacent to the parenchima in the marginal, trabecular and medullary sinuses exhibits and interrupted course, so as to allow a free to and from passage of cells between the parenchimal and sinus compartments. The Authors also compare the ultrastructural features of the lymph node sinuses in Chiroptera with those of other mammals including man.

Animals↗