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Biomedical subjects

R Galambos

Publications and source records attributed to R Galambos.

70 records · Page 4Linked to original sources

Inconsistency of auditory middle latency and steady-state responses in infants.

Auditory middle latency and steady-state responses (MLR/SSRs) were recorded in normal infants (aged 3 weeks to 28 months) and adults. SSR amplitudes were maximum using stimulus presentation rates near 40 Hz in adults. By contrast, the infant data showed no consistent amplitude maximum across the rates tested (9-59 Hz). With the exception of the brain-stem response wave V to MLR Na deflection, MLR components in infants' responses to 10.85 Hz clicks did not show any consistent pattern. To investigate the hypothesis that the 40 Hz SSR is derived from overlapping of the 10 Hz MLR components, 43.4 Hz SSRs were synthesized from the responses recorded at 10.85 Hz and compared with those recorded at 43.4 Hz. The predictive accuracy of the synthesized 43.4 Hz SSRs was significantly better in adults than in infants. The results of these studies indicate the presence of large age-related differences in the auditory MLR and SSR, and in the relationship between the two responses.

Acoustic Stimulation↗

The auditory brain stem response reliably predicts hearing loss in graduates of a tertiary intensive care nursery.

Babies (N = 642) were tested for auditory disorder, using the auditory brain stem response (ABR), at the time of their discharge from a tertiary intensive care nursery (ICN). Of those with ABR threshold elevation in one or both ears (N = 97), 61% (N = 59) were retested some months later by a battery of audiological tests; 21 (N = 3.3% of the 642) suffered binaural peripheral loss and 11 (1.7%) now wear hearing aids. These new data, when combined with similar data previously reported from the same ICN, yield a sample of 1613 babies examined during a 5.8-year period from which these conclusions emerge: (1) About 16% of our ICN babies leave the hospital with reduced sensitivity in one or both ears; (2) the hearing deficiency is permanent for 8 to 10%; (3) the loss is sensorineural, bilateral, and so severe for about 4% that hearing aids will be required to optimize their language and psychosocial development. Use of the ABR procedure for neonatal hearing testing is the target of several criticisms: it is being applied too early in life; its predictions about permanent hearing loss are unacceptably inaccurate; or/and it is too costly. We discuss these and still other objections that have been raised.

Audiometry↗