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Biomedical subjects

R Gabriel

Publications and source records attributed to R Gabriel.

At least 163 records · Page 9Linked to original sources
PubMed1982

Acute tubular necrosis, caused by therapeutic doses of paracetamol?

Reversible acute renal failure of unknown cause occurred in two men after taking paracetamol in therapeutic doses. Tubular necrosis was present; liver function was normal. We postulate that these patients might have formed arylating metabolites of paracetamol within the kidney which bound to tubular cells causing necrosis. Such events may not be infrequent but are unrecognized because paracetamol is not regarded as nephrotoxic in standard dosage. We suggest that a detailed history in cases of acute renal failure should include direct enquiry as to the ingestion of paracetamol in order to collect information on this point.

Acetaminophen↗
PubMed1981

Aluminium sucrose biscuit fillings to control hyperphosphataemia in patients undergoing dialysis.

Aluminium hydroxide is used to prevent hyperphosphataemia in patients undergoing dialysis, but many standard preparations are unpalatable. In this study hydrated aluminium sucrose was suspended in synthetic cream and used as a biscuit filling. Six patients undergoing dialysis took part in five five-week study periods comparing different forms of treatment. No significant difference was found between serum phosphate concentrations measured during standard treatment and those measured during treatment with aluminium sucrose biscuits. There was no significant difference in serum phosphate concentrations when the patients were given placebo biscuits and when they received no treatment. Aluminium sucrose presented in this form was an adequate phosphate binder and was acceptable to the patients.

Aluminum↗
PubMed1981

Comparison of the chronic effects of bendrofluazide, bumetanide and frusemide on plasma biochemical variables.

Eleven plasma variables have been studied in 18 elderly patients with cardiac oedema treated with bendrofluazide, frusemide and bumetanide, using a fully balanced, cross-over trial design. Bumetanide caused the least disturbance of plasma potassium and bendrofluazide the greatest. Frusemide produced an intermediate effect. The difference between the changes in plasma potassium produced by bumetanide and bendrofluazide was significant (P less than 0.02).

Aged↗
PubMed1981

Acute interstitial nephritis complicating Legionnaires' Disease.

An acute interstitial nephritis was found in a patient with sudden renal failure and lung infection caused by Legionella pneumophilia. Our patient regained and maintained normal renal function after a short period of dialysis support. The diagnosis should be considered in any patient with a chest infection complicated by acute renal failure especially if confusion is disproportionate to the degree of uremia.

Acute Disease↗
PubMed1980

[Clearance determination with 131I-labelled hippurate (author's transl)].

The effect of the iodine not bound to the nuclear drug 131I hippurate on nuclear medical renal diagnosis by means of whole body clearance has been investigated. The results show that whatever clearance method is used, the tubular secretion performance decreases with increasing free iodine. This results in considerable error if the free iodine in the nuclear drug is not taken into account in the clearance calculation.

Adult↗
PubMed1980

Removal of metronidazole by haemodialysis.

The removal of the anti-anaerobic antibiotic metronidazole has been studied in oliguric patients. The drug and its principal metabolite are rapidly removed by haemodialysis so that the plasma concentration quickly falls below the therapeutic range. Hence a further dose of metronidazole would be needed after dialysis to restore an adequate plasma concentration.

Adult↗
PubMed1979

The "drug lunch".

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