Family situation of the juvenile diabetic.
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Biomedical subjects
Publications and source records attributed to R Güell.
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The occurrence of bladder disorders, such as increase in vesical volume, incomplete vesical evacuation, and increase in first morning micturition, as well as its association with certain clinical factors, such as duration of diabetes, age at onset, degree of metabolic control, and symptoms of vesical autonomic neuropathy, were studied in a group of 55 diabetic children using vesical echography. Morning diuresis and vesical volume for age were previously determined in a group of 40 non-diabetic children used as controls. The echographic measurements permitted the estimation of maximum normal vesical volume for each age group, yielding the following distribution: 6-8 years, up to 263.7 ml; 9-11 years, up to 375.7 ml; 12-14 years, up to 445.3 ml. Analyzing first morning micturition by age in the control group, we found the following maximum values: 6-8 years, up to 263.5 ml; 9-11 years, up to 380.1 ml; 12-14 years, up to 394.6 ml; 67.27% of all diabetic children had bladder disorders. It was demonstrated that routine determination of the first morning micturition in the diabetic child would be an excellent index for detecting early disorders of vesical function. The existence of a statistically significant association (p less than 0.05) of poor metabolic control to development of these disorders, as well as to symptoms referred at this level, was confirmed. No other statistically significant association was found between the occurrence of these bladder disorders and other factors such as duration and age at onset of the disease.
INTRODUCTION: Congenital hypothyroidism is the most important cause of preventable mental retardation. Since the use of programmes for early detection, mental retardation due to cretinism has been abolished and current investigations seek to detect subtle damage due to foetal hypothyroidism and strategies to minimize such deficits. OBJECTIVE: This study presents the results of neurocognitive assessment of a group of 19 children aged 8 in the Cuban Programme for the early detection of Congenital Hypothyroidism. PATIENTS AND METHODS: The programme is based on the use of umbilical cord serum levels of thyrotropin (TSH), using the Elisa ultramicro method (SUMA) and substitutive treatment with sodium levothyroxine and a programme of neuropsychiatric stimulation until 5 years old. RESULTS: The results showed that the intelligence quotients of children with hypothyroidism were not statistically different from paired controls, and thus demonstrate the efficacy of the programme. On evaluation using computerized techniques for the detection of subtle disorders of the maintenance of attention, deficiencies were found. Analysis of the conventional EEG showed that in 13 cases recordings were normal, 4 had generalized cortical damage, 1 had cortico-subcortical damage and the remainder had signs of focal irritation. On the quantitative EEG, correlation between the attention variables and absolute values (MV2/Hz) were calculated for each derivation and associations found mainly in the right parietal and left frontal regions. CONCLUSION: The effect of stimulating development in these patients is discussed.