An evaluation of valvar and shunt lesions in children is directed toward appraising the need for, and timing of, surgical repair or palliation as well as demonstrating the cardiac anatomy which will, in turn, direct the type of surgery to be chosen. Static dimension measurements as well as dynamic measurements of wall velocity and time intervals are atraumatic and easily obtained values that increase our sensitivity to early cardiac decompensation. Contrast studies add both functional and anatomic information. Although one-dimensional time-motion scanning remains an invaluable source of anatomic detail, two-dimensional imaging has made positional information clearer and more reliable. The combined use of these three techniques offers the most complete evaluation of children with volume and pressure overload lesions.

Aortic Valve↗

PubMedDate not supplied

[125I]-omega conotoxin binding to human frontal cortex from normal, Alzheimer's and non-Alzheimer's dementia patients.

We studied the binding of the calcium antagonist neurotoxin [125I]-omega conotoxin (GVIA) in age-matched human brains from normal, Alzheimer's disease and non-Alzheimer's dementia patients. Crude preparations of plasmalemmal membranes from frontal cortex were utilized. Saturation isotherms were subjected to Scatchard analysis to determine maximal binding capacity (Bmax) and binding affinity (Kd). In all brain samples tested, [125I]-GVIA binding was homogenous to a single class of high affinity binding sites. Scatchard analysis of saturation isotherms gave the following estimates for normal brains (mean +/- S.D., n = 7): Bmax = .630 +/- .200 pmol/mg and Kd = .177 +/- .054 nM. No significant change was observed in the Kd or Bmax estimates for [125I]-omega conotoxin binding in Alzheimer's disease or non-Alzheimer's dementia brains when compared to normal brains. Although these findings do not rule out the existence of localized changes in calcium channel receptor binding in the frontal cortex of Alzheimer's disease patients, the results do suggest that the neuronal voltage sensitive calcium channel may be unaltered in Alzheimer's disease.

Aged↗

PubMedDate not supplied

The relationship between nasalance and nasal resistance to airflow.

The relationship between nasal airway resistance and nasalance in healthy volunteers and in subjects suffering from symptoms of acute rhinitis was investigated. A non-invasive objective measure of nasalance using the Nasometer (Kay Electronics) was used and an inverse correlation between airway resistance and nasalance was found (r = 0.67, r2 = 0.46, p less than 0.0001). The effect of a topical nasal decongestant on nasal airway resistance and nasalance was investigated, and significant changes were seen both in resistance and nasalance (p less than 0.0001) with a correlation in the changes seen in both parameters (r = 0.82, r2 = 0.66, p less than 0.0001). The measure of nasalance may be useful in assessing various forms of nasal treatment including nasal, adenoidal and palatal surgery. The measurement of nasalance is well tolerated by subjects of all ages and is particularly useful in subjects with high nasal resistance where rhinomanometry tends to be unstable.

Acute Disease↗

PubMedDate not supplied

A new clinical measure of external laryngeal size which predicts the fundamental frequency of the larynx.

A method for accurately predicting the average fundamental frequency of the larynx from an external measurement of laryngeal size has been developed. In 21 human cadaveric dissections we have demonstrated that the external height of the larynx (measured from the lower border of the cricoid cartilage to the upper border of the thyroid notch) was significantly correlated to the length of the membranous vocal fold (r = 0.94, p less than 0.001). This same external measure of laryngeal size in 115 healthy volunteers was found to be related to their voice fundamental frequency. Significant differences were found between males and females with respect to both laryngeal size (p less than 0.001) and voice fundamental frequency (p less than 0.001). A strong correlation between the external laryngeal measurement and speaking fundamental frequency was found with an overall correlation coefficient for both sexes of 0.8 (p less than 0.001). Using this external measurement, it may be possible to accurately predict the fundamental frequency in males and females. It is proposed that such a measurement could be used to identify various laryngeal diseases and also serve as a basis for corrective treatment in various voice disorders.

Aged↗

PubMedDate not supplied

The lifespan personal health record.

A system for entry of health data in a computer-based patient record by lay individuals is described. The lay user is supported in data entry and data clarification, as well as by system-supported summarization of the data in context to show relationships, highlight sentinel events, and assist in evaluation of alternative decisions and actions as needed.

Decision Support Techniques↗

PubMedDate not supplied

MR imaging of choroid plexus lipomas.

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Cerebral Ventricle Neoplasms↗

PubMedDate not supplied

Design without danger.

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Accidents, Occupational↗

PubMedDate not supplied

Cardiopulmonary resuscitation.

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Cardiopulmonary Resuscitation↗