Biomedical subjects

R G Wight

Publications and source records attributed to R G Wight.

38 records · Page 3Linked to original sources

PubMedDate not supplied

A comparison of the effects of xylometazoline on nasal airflow, and on blood flux as measured by laser Doppler flowmetry.

The purpose of this study was to examine whether changes in mucosal blood flow measured directly by laser Doppler flowmetry corresponded to changes in turbinate blood volume measured indirectly as changes in nasal airflow. Fifteen healthy subjects underwent active anterior rhinomanometry and laser Doppler flowmetry prior to and following the topical application of 100 micrograms of xylometazoline to each nostril. A significant decrease in nasal resistance occurred in the probe nostril (p less than 0.001) and the non probe nostril (p less than 0.005) following xylometazoline. A significant fall in blood flux occurred with xylometazoline (p less than 0.05). There was no correlation between the percentage change in airflow (rhinomanometry) and the percentage change in blood flux (laser Doppler) following xylometazoline. These results suggest that laser flowmetry and rhinomanometry measure different parts of the inferior turbinate vascular bed.

Adult↗

PubMedDate not supplied

A comparison of the effects of two commonly used vasoconstrictors on nasal mucosal blood flow and nasal airflow.

This study compared two commonly used vasoconstrictors, cocaine and xylometazoline. Non-invasive techniques of measurement were utilised, with active anterior rhinomanometry indirectly assessing changes in nasal mucosal blood volume, and laser Doppler flowmetry assessing changes in nasal mucosal blood flow. Twelve healthy volunteers received 0.1 ml of the topical vasoconstrictor at the anterior end of both inferior turbinates. Following the application of xylometazoline, a significant rise in nasal airflow (p less than 0.005), and a significant fall in blood flux occurred in the probe nostril (p less than 0.05). Following the application of cocaine, no significant change in nasal airflow occurred (p less than 0.05), but a significant fall in blood flux occurred in the probe nostril (p less than 0.02). A comparison of the paired data for the same subject demonstrated no significant difference in the change in blood flux produced by xylometazoline and cocaine, but a significant difference in the change in airflow produced by the two vasoconstrictors (p less than 0.005).

Adrenergic alpha-Agonists↗