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Biomedical subjects

R G Phelps

Publications and source records attributed to R G Phelps.

64 records · Page 4Linked to original sources
PubMed1985

Ultrastructural immunocytochemical localization of type I procollagen in cultured human fibroblasts.

An immunoelectron microscopic study of cultured human fibroblasts was performed with antibody specific for the carboxyl propeptides of human type I procollagen (Goldberg et al., 1985). In cells permeabilized with detergent, the unlabeled antibody peroxidase-antiperoxidase method localized the antigen in the rough endoplasmic reticulum, in the Golgi complex, and upon the plasma membrane. Immunostained thread-like periodic fibrillar aggregates within cytoplasmic vacuoles were not apparent. Extracellular fibrils 20-80 nm in thickness were diffusely and heavily stained. Immunostaining also defined a thin extracellular periodic fibril (diameter 10-20 nm; axial period 53.7 nm +/- 6.5 S.D.). These data are discussed in terms of current views of procollagen secretion and collagen fibrillogenesis.

Cell Line↗
PubMed1985

Papillary adenoma of the nipple: analysis of fifteen new cases.

Fifteen cases of papillary adenoma (florid papillomatosis, erosive adenomatosis) of the nipple were compared with forty examples of syringadenoma papilliferum, twenty-four of hidradenoma papilliferum, and one hundred of breast carcinoma metastatic to skin. Clinically, papillary adenoma of the nipple typically occurred in a female patient as an erosion, ulceration, or mass that was sometimes accompanied by serous or bloody discharge from the nipple and was frequently misdiagnosed as Paget's disease. Histologically, there was usually a papillary and adenomatous growth in the corium that connected with the surface and showed a lining of apocrine type secretory epithelium, a sometimes plasmacytic stroma, and horn cysts in the upper corium. Papillary adenoma of the nipple is often histologically misinterpreted as syringadenoma papilliferum, hidradenoma papilliferum, or low-grade adenocarcinoma, but it has received almost no attention in the dermatology literature.

Adenoma, Sweat Gland↗
PubMed1983

Carcinoma of the thyroglossal duct.

Seven patients with carcinoma in a thyroglossal duct cyst have received treatment over a 15 year period. Findings in all of these patients reflect the likelihood of carcinoma arising within thyroglossal duct tissue. In each patient there was sufficient histologic evidence of the presence of a thyroglossal duct cyst and carcinoma arising within an intimate admixture of normal thyroid tissue in the cyst wall. In the absence of a history of irradiation and with separation of the carcinoma from the pyramidal lobe of the thyroid, excision of the thyroglossal cyst alone by traditional means seems appropriate. Our experience as well as a review of reported cases to date indicate that distant metastases are extremely rare and the prognosis excellent.

Adenocarcinoma↗
PubMedDate not supplied

Immune recognition of glomerular antigens.

Autoimmunity is thought to cause most varieties of glomerulonephritis including membranous nephropathy, minimal-change nephropathy, Goodpasture's disease and possibly IgA nephropathy. Much effort has been and is directed at understanding the mechanisms of immune system driven inflammation and of the consequent renal injury and repair or scarring. The purpose of this article is to focus attention on the way the immune system recognizes kidney autoantigens, a process that must be a pivotal in the initiation of autoimmune kidney disease.

Amino Acid Sequence↗
PubMedDate not supplied

Update on panniculitis.

There is considerable confusion regarding the pathogenesis, nosology and treatment of panniculitis. This paper examines newer concepts in five types of panniculitis: i.e., histiocytic cytophagic panniculitis, erythema induratum, lipodermatosclerosis, pancreatic panniculitis and alpha-1-antitrypsin deficiency panniculitis. Recent developments in etiology, pathogenesis, molecular techniques, and therapy are discussed.

Erythema Induratum↗
PubMedDate not supplied

Cutaneous granulomas masquerading as tuberculoid leprosy in a patient with congenital combined immunodeficiency.

Combined immunodeficiency disorders are characterized by abnormalities in cellular and humoral immunity. This classification includes common variable immunodeficiency (CVI), a primary immunodeficiency disorder characterized by hypogammaglobulinemia, recurrent bacterial infections, and significant T-cell abnormalities. Associated autoimmune diseases include rheumatoid arthritis, pernicious anemia, idiopathic thrombocytopenic purpura, and systemic lupus erythematous. Granulomatous lesions in lymphoid tissues, solid organs, and skin have been reported. We describe a patient with CVI who developed cutaneous granulomas with perineural invasion; to our knowledge, this is a previously undescribed feature.

Adult↗
PubMedDate not supplied

Childhood longitudinal melanonychia: case reports and review of the literature.

"Longitudinal melanonychia" refers to a brown or brown-black longitudinal band on a fingernail or toenail. A number of conditions can cause longitudinal melanonychia, but its main importance is that, in some patients, it may indicate the presence of a subungual malignant melanoma. Hyperpigmented nail bands are not uncommon in African-American, Latino and Asian patients, especially those over sixty years of age, and are often multiple in these groups. Longitudinal melanonychia is most worrisome when there is a solitary, dark, broad longitudinal band with pigment extending over the proximal nail fold (Hutchinson's sign). Such findings are considered to be a strong indication for biopsy of the nail matrix to rule out melanoma. Since nail matrix biopsy sometimes results in permanent nail deformity, and since the incidence of malignant melanoma is quite small in the pediatric age group, there is some controversy as to whether this procedure should routinely be performed in children. We report two cases of dramatic longitudinal melanonychia in toddlers and review the current literature on the management of this striking condition in the pediatric age group.

Adolescent↗
PubMedDate not supplied

Cutaneous polyarteritis nodosa after streptococcal necrotizing fasciitis.

Polyarteritis nodosa (PAN) is a necrotizing arteritis of small and medium-sized vessels. It may present with hypertension and/or renal insufficiency. Peripheral neuropathy, myopathy, joint pains, testicular pain, and ischemic myalgias may also be seen. Gastrointestinal involvement may lead to gangrene of the bowel, peritonitis, perforation, intra-abdominal hemorrhage, and pancreatitis. The cutaneous manifestations include tender subcutaneous nodules grouped along the course of superficial arteries of the lower extremities, with or without an overlying livedo reticularis. Although multisystem involvement is characteristic, sometimes only one organ or system may be involved. Associations with viral hepatitis (both B and C) and streptococcal infection have been established for PAN. Recurrent strep infections of the upper respiratory tract, streptococcal glomerulonephritis and rheumatic fever have previously been linked to PAN. This report extends the spectrum of associated streptococcal infections to include necrotizing fasciitis.

Adult↗
PubMedDate not supplied

Fine needle aspiration cytology of pilomatrixoma (calcifying epithelioma of Malherbe). Report of a case.

A case of a facial pilomatrixoma (calcifying epithelioma of Malherbe) in a child initially diagnosed following fine needle aspiration is presented. On cytologic examination, basaloid cells, multinucleated giant cells and deposits of calcium were identified. Adjacent to the basaloid cells were acellular masses suggestive of, but not diagnostic of, ghost cells. The diagnosis was confirmed by histology.

Biopsy, Needle↗